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ISSN 0187-5337 (Print)
Instituto Nacional de Perinatología

2002, Number 4

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Perinatol Reprod Hum 2002; 16 (4)

Polidactilia preaxial en recién nacidos expuestos a ácido valproico durante el embarazo: presentación de dos casos

Aguinaga-Ríos M, Llano-Rivas I, Mayén-Molina DG, García-Cavazos R

Language: Spanish
References: 27
Page: 180-186
PDF size: 731.11 Kb.


ABSTRACT

The exposure to valproic acid during pregnancy has been associated with the presence of minor facial abnormalities and various congenital defects. We report two cases exposed to valproic acid during pregnancy with an extra triphalangeal thumb without a family history of this anomaly.


REFERENCES

  1. Perucca E. Pharmacologic and therapeutic properties of valproate: a summary after 35 years of clinical experience. CNS Drugs 2002; 16: 695-714.

  2. Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation: A reference guide to fetal and neonatal risk. Baltimore: Williams and Wilkins; 1999.

  3. Clayton-Smith J, Donnai D. Fetal valproate syndrome. J Med Genet 1995; 32: 724-7.

  4. Hanson JW, Myrianthopoulos NC, Harvey MA, Smith DW. Risks to the offspring of women treated with hydantoin anticonvulsants, with emphasis on the fetal hydantoin syndrome. J Pediatr 1976; 89: 662-8.

  5. Sharony R, Garber A, Viskochil D. Preaxial ray reduction defects as part of valproic acid embryopathy. Pren Diagn 1993; 13: 909-18.

  6. Dalens B, Raynaud E-J, Gaulme J. Teratogenicity of valproic acid. J Pediatr 1980; 97: 332-3.

  7. Omtzigt JG, Los FJ, Grobbee DE, Pijpers L, Jahoda MGJ, Brahoenburg H. The risk of spina bifida aperta after first trimester valproate exposure in a prenatal cohort. Neurology 1992; 42(Suppl. 5): 119-25.

  8. Gaily E, Granstrom M-L, Hiilesmaa V. Minor anomalies in offspring of epileptic mothers. J Pediatr 1988; 112: 520-9.

  9. DiLiberti JH, Farndon PA, Dennis NR. The fetal valproate syndrome. Am J Med Genet 1984; 19: 473-81.

  10. Shorvon S. Antiepileptic drug therapy during pregnancy: the neurologist’s perspective. J Med Genet 2002; 39: 248-50.

  11. Faiella A, Wernig M, Giacomo G, Hostick U, Hofmann C, Hustert E, Boncinelli E, Balling R, Nadeau J. A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression. Hum Mol Genet 2000; 19: 227-36.

  12. Chen G, Yuan PX, Jiang YM, Huang LD, Manji HK. Valproate robustly enhances AP-1 mediated gene expression. Brain Res Mol Brain Res 1999; 64: 52-8.

  13. Graham J Jr, Brown FE, Hall BD. Thumb polydactyly as a part of the range of genetic expression for thenar hypoplasia. Clin Pediatr 1987; 26: 142.

  14. Stevenson R, Hall J, Goodman R. Human malformations and related anomalies. Vol. II. New York: Oxford University Press; 1983.

  15. Holmes LB. The teratogenicity of anticonvulsant drugs: A progress study. J Med Genet 2002; 39: 245-7.

  16. McFadden DG, Mc Anally J, Richardson JA, Charite J, Olson E. Development 2002; 129: 3077-88.

  17. Koch S, et al. Possible teratogenic effect of valproate during pregnancy. J Pediatr 1983; 103: 1007-8.

  18. Knight AH, Rhind EG. Epilepsy and pregnancy: a study of 153 pregnancies in 59 patients. Epilepsia 1975; 26: 631-5.

  19. Holmes LB, Harvey EA, Coull BA, Huntington KB, Khoshbin S, Hayes AM, et al. The teratogenicity of anticonvulsant drugs. N Engl J Med 2001; 344: 1132-8.

  20. Yerby MS. Pregnancy, teratogenesis and epilepsy . Neurol Clin 1994; 12: 749-71.

  21. Hiilesmaa VK, Teramo K, Granstrom ML, et al. Serum folate concentrations during pregnancy in women with epilepsy: Relation to antiepileptic drug concentrations, number of seizures, and fetal outcome. Br Med J 1983; 287: 577-9.

  22. Chen B, Wang JF, Hill BC, Young LT. Lithium and valproate differentially regulate brain regional expression of phosphorylated CREB and c-fos. Brain Res Mol Brain Res 1999; 70: 45-53.

  23. Clay SA, McVie R, Chen HC. Possible teratogenic effect of valproic acid. J Pediatr 1981; 99: 828.

  24. Jäger-Roman E, Deichl A, Jakob S. Fetal growth major malformations and minor anomalies in infants born to women receiving valproic acid. J Pediatr 1986; 108: 887-1004.

  25. Bailey J, Pool RW. Valproic acid and fetal abnormality. Br Med J 1982; 286: 190.

  26. Colls P, Blanco J, Martínez-Pasarell O, Vidal F, Egozcue J, Márquez C, Guitart M, Templado C. Chromosome segregation in a man heterozygous for a pericentric inversion, inv(9)(p11q13), analyzed by using sperm karyotyping and two-color fluorescence in situ hybridization on sperm nuclei. Hum Genet 1997; 99: 761-5.

  27. Gardner RJM and Sutherland GR. Chromosome abnormalities and genetic counseling. Oxford: University Press; 1989.




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