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Instituto Nacional de Perinatología

2008, Number 2

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Perinatol Reprod Hum 2008; 22 (2)

Neurobiología del bajo peso al nacer y su asociación con la diabetes tipo 2

Manuel-Apolinar L, Hernández-Valencia M

Language: Spanish
References: 71
Page: 155-164
PDF size: 453.40 Kb.


ABSTRACT

Fetal intrauterine growth retardation (IUGR) relates to maternal undernutrition, as well as social and enviromental factors in wich develops the gestation, since interfere in the circulation and efficacy of the placenta. The IUGR can be done irreversible after the birth and to be manifested as psicomotriz deficient development and neurological backwash, but has been established that have a recuperation of weight during the firts 2 years of life, with index of body mass (IBM) that itself increase quickly although this disorder seems to relate with insulin resistance, since has been describe a relation of birth weight and the increase of risk in type 2 diabetes in the adult age, as well as apparition of obesity, hypertension and glomerulophaty, independdent of the inheritance gene. in the muscle from obese people an alteration in the synthesis of glucogen exist due to a smaller activity of the glucogen-sintasa. The number of insulini receptors diminishes, mainly in adipose and muscular tissue, therefore in these cases, the nutrients that arrive upon adipose tissue for its storage increase and consequently the muscle utilizes more fatty acids and less glucose as expenditure of energy, originating decrease in uptake and utilization of glucose stimulated by the insulin. The food intake system is bases on feedback through by the expense of energy and the functions of the nervous and endocrine systems, therefore, as smaller and greater in the weight at born are both risks of suffering complications.


REFERENCES

  1. Coronel CC, Rivera LI. Peso bajo al nacer. Su influencia en al salud durante el primer año de vida. Rev Mex Ped 2003;70:283-7.

  2. Poulsen P, Vaag AA, Kyvik KO, Moller Jensen D, Beck-Nielsen H. Low birth weight id associated with NIDDM in discordant monozygotic and dizygotic twin pairs. Diabetologia 1997;40:439-46.

  3. Calderón GJ, Vega MG, Velásquez TJ, Morales CR, Vega MA. Factores de riesgo materno asociados al parto pretérmino REV Med IMSS 2005;43(4):339-42.

  4. Sathja T, Suchada R, Chompunut S. Obstetrics and perinatal outcomes of Thai pregnant adolescents: A retrospective study. Internation J Nursing Stud 2007;44:1158-64.

  5. Edwards-Silva R, Ogunyemi D, Gornbein J, Gregory K, Hobel C. Ethnic variations of sexual dimorphism in fetal growth. Am J Obstet Gynecol 2006;195:S49.

  6. Paek B Eastwood K, Utzschneider K, Tong J, Gerchman F, Robilio D, Fujimoto W, Kahn S, Carr D. Low birth weight among adults with a family history of diabetes decreases the risk of metabolic syndrome. Am J obstet Gynecol 2006;195:S3.

  7. Szostak-Wegierek D, Szamotulska K, Szponar L. Influence of maternal nutrition on infant birthweight. Ginekol Pol 2004;75:692-8.

  8. Aagaard NE, Hammer BB, Vaeth M, Rasmussen MK, Henriksen BT, Olsen J. Obesity, gestational weight gain and preterm birth: a study within the Danish National Birth Cohort. Paed Perinatal Epidemiol 2007;21(1):5-14

  9. Barker DJ. The developmental origins of insulin resistance. Horm Res 2005;64:2-7.

  10. Barrer DJ; Clark PM, Cox LJ, Fall C, Osmond C, Winter PD. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 1991;303:1019-22.

  11. Hales CN, Barrer DJP, Clark PMS, Cox U, Fall C, Osmond C, Winter PD. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ 1991;303:1019-22.

  12. Barker DJ, Hales CN, Fall CH, et al. Type 2 (non-insulindependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): ralation to reduced fetal growth. Diabetologia 1193;36:62-7.

  13. Lezama HMP, Díaz GJM, Rodríguez ZR. Prevalencia de bajo peso al nacimeinto en un Hospital General de segundo nivel. Salud Tab 2001;7(2):401-3.

  14. Simmons RA, Templeton LJ, Gertz SJ. Intrauterine growth retardation leads to the development of type 2 diabetes in the rat. Diabetes 2001;50:2279-86.

  15. Hernández-Valencia M, Zárate A. El riesgo de diabetes gestacional se establece desde la vida fetal y posnatal. Ginecol Obstet Mex 2003;71:60-5.

  16. Jiménez-Chillaron C.J., Hernández-Valencia M., Reamer C. y cols. ?-Cell secretory dysfunction in the pathogenesis of low birth weight associated diabetes. Diabetes 2005;54:702-11:

  17. Harder T, Rodekamp E, Schellong K Dudenhausen JW, Plagemann A. Birth Weight and Subsequent Risk of Type 2 Diabetes: a meta-analysis Am J Epidemiol 2007;165:849-57.

  18. Gerich JE. Clinical significance, pathogenesis, and management of postprandial hyperglycemia. Arch Intern Med 2003;163(11):1306-16.

  19. Polonsky KS, Given BD, Van Cauter E. Twenty-four-hour profiles and patterns of insulin secretion in normal and obese subjects. J Clin Invest 1988;81:442-8.

  20. Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP, et al Quantification of the relationship between insulin sensitivity and B-cell function in human subjects. Evidence for a hyperbolic function. Diabetes 1993;42:1663-72.

  21. Mancillas AL, Gómez PFJ, Rull AAJ. Diagnóstico y clasificación de la diabetes mellitus. Rev Endocrinol Nutric 2002;10(2):63-8.

  22. Moran A, Jacobs DJ, Steinberger J, Hong Ch, Prineas R, Luepker R, Sinaiko A. Insulin Resistance During Puberty Results From Clamp Studies in 357 Children. Diabetes 1999;48:2039-44.

  23. Buchanan TA, Metzger BE, Freinkel N, Bergman RN. Insulin sensitivity and β-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes. Am J Obstet Gynecol 1990;162:1008-14.

  24. De Frozo RA. Glucose intolerance of aging. Evidence for tissue insensitivity to insulin. Diabetes 1979;28:1095-101.

  25. Kahn S, Hull R, Utzschneider K. Mechanisms linking obesity to insulin resistance and type 2 diabetes Nature 2006;444(14):840-6.

  26. MCCance G, Pettitt DJ, Hanson RL, Jacobsson LTH, Knowler WC, Bennett PH. Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype? BMJ 1994;308:942-5.

  27. Harder T, Rodekamp E, Schellong K, Dudenhausen JW, Plagemann A. Birth weight and subsequent risk of type 2 diabetes: a meta-analysis Am J Epidemiol 2007;165:849-57.

  28. Hotamisligil GS. Inflammation and metabolic dosorders. Nature 2006;444(14):860-7.

  29. Reaven GM. Role of insulin resistance in human disease. Diabetes 1988;37:1595-607.

  30. Montemayor ODM, Montes VJ. Diabetes mellitus tipo 2 en niños y adolescentes: un problema emergente. Med Univer 2004;6(24):204-11.

  31. Zhang Y, Proenca R, Maffei M, Barone L, Leopold L, Friedman JM. Positional cloning of the mouse ob gene and its human homologue. Nature 1994;372:425-32.

  32. Ravussin E. Metabolic differences and the development of obesity. Metabolism 1995;9(Suppl. 3):12-4.

  33. Pan DA, Lillioja SA, Kriketos AD, Milner LA, Baur C, Bogardus AB, Jenkins AB. Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 1997;46:983-8.

  34. Kim JY, Nolte LA, Hansen PA, Han D, Kawanaka K, Holloszy OJ. Insulin resistance pof muscle glucosa tranport in male and female rats fed a hig-sucrose diet. Am J Physiol 1999;276:R665-72.

  35. Després JP. Health consequences of visceral obesity. Ann Med 2001;33(8):534-41.

  36. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, Marks JS. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 2003;289(1):76-9.

  37. Meehan WP, Buchanan TA. Chronic insulin administration elevates blood pressure in rats Hypertension 1994;23:1012-7.

  38. Anca D, Michael D. Oxidative stress in a rat model of obesity induced hypertension. Hypertension 2001;37:554-60.

  39. Heise T, Magnusson K. Insulin resistance and the effect of insulin on blood pressure in essential hypertension. Hypertension 1998;32:243-8.

  40. Ceddia RB, Heikki AK, Zierath JR, Sweeney G. Analysis of paradoxical observations on the Association between leptin and insulin resistance. FASEB J 2002;16:1163-76.

  41. Walder K, Filippis A, Clark S, Zimmer P, Collier GR. Leptin inhibits insulin binding in isolated rat adipocytes. J Endocrinol 1997;155:R5-7.

  42. Rodríguez VM, Macarulla MT, Echeverría E, Portillo MP. Lipolysis induced by leptin in rat adipose tissue from different anatomical locations. Eur J Nutr 2003;42:149-53.

  43. Seufert J. Leptin effects on pancreatic beta-cell gene expression and function. Diabetes 2004;53(Suppl. 1):152-8.

  44. Bruun JM, Pedersen SB, Kristensen K, Richelsen B. Effects of pro-inflammatory cytokines and chemokines on leptin production in human adipose tissue in vitro. Mol Cell Endocrinol 2002;190:91-9.

  45. Considine RV, Sinha ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, et al. Serum immunoreactiva-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996;334:292-5.

  46. Montague CT, Farooqui S, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early onset obesity in humans. Nature 1997;387:903-8.

  47. Clement K, Vaisse C, Lahlous N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398-401.

  48. Fei H, Okano HJ, Li C, Lee GH, Zhao C, Darnell R, Friedman JM. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci USA 1997;94:7001-5.

  49. Bjorbaek C, Uotani S, Da Silva B, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997;272:32686-95.

  50. Ghilardi N, Skoda RC. The leptin receptor activates Janus tyrosine kinase 2 and signals for proliferation in a factor-dependent cell line. Molecular Endocrinol 1997;11:393-9.

  51. Shigeo Y, Sagawa N, Yamamoto H, Masuzaki H, Nakao K, Kawamura M, et al. Role of premature surge in obesity resulting from intrauterine undernutrition. Cell Metabolism 2005;1:371-8.

  52. Spanswick D, Smith MA, Groppi V, Logan SD, Ashford ML. Leptin inhibits hypothalamic neurons by activation of ATPsensitive potassium channels. Nature 1997;390:521-5.

  53. Shanley LJ, Irving AJ, Rae MG, Ashford ML, Harvey J. Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K + channels. Nat Neurosci 2002;5:299-300.

  54. Harvey J, McKenna F, Herson PS, Spanswick D, Ashford ML. Leptin activates ATP-sensitive postassium channels in the rat insulin-secreting line, CRI-G1. J Physiol 1997;504:527-35.

  55. Harvey J, Ashford ML. Leptin in the CNS: much more than a satiety signal. Neuropharmacol 2003;44:845-54.

  56. Sánchez JC. Perfil fisiológico de la leptina, Col Med 2005;36(1):50-9.

  57. Kitabchi EA, Umpierrez EG. Changes in serum leptin in lean and obese subjects with acute hyperglycemic crises. J Clin Endocrinol Metab 2003;88:2593-6.

  58. Schwartz WM, Woods CS, Porte D, Seeley JR, Baskin GD. Central nervous system control od food intake. Nature 2000;404:661-71.

  59. Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998;395:763-70.

  60. Chan JL, Mietus JE, Raciti PM, Goldberger AL, Mantzoros CS. Short-term fasting-induced autonomic activation and changes in catecholamine levels are not mediated by changes in leptin levels in healthy humans. Clin Endocrinol 2007;66(1):49-57.

  61. Elmquist JK, Bjorbaek C, Ahima RS, Flier JS, Saper CB. Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol 1998;395:535-47.

  62. Kolb B, Whishaw IQ. Cerebro y conducta. 1era. Ed. Madrid, España: Edit Mc Graw Hill; 2002.

  63. Ellingrod VL, Miller D, Ringold JC, Perry PJ, Hales CN. Distribution of the serotinin 2C (5HT2C) receptor gene -759C/T polymorphism in patients with schizophrenia and normal controls. Psychiatr Genet 2004;14(2):93-5.

  64. Miyata S, Hirano S, Kamei J. Diabetes attenuates the antidepressant-like effect mediated by the activation of 5-HT1A receptor in the mouse tail. Neuropsychopharm 2004;29:461-9.

  65. Malik KF, Young WS 3rd. Localization of binding sites in the central nervous system for leptin (OB protein) in normal, obese (ob/ob), and diabetic (db/db) C57BL/6J mice. Endocrinol 1996;137(4):1497-500.

  66. Lackovic Z, Salkovic M. Streptozotocin and alloxan produce alterations in rat brain manoamines independently of pancreatic beta cells destructions. Life Sci 1990;46:49-54.

  67. Sugimoto Y, Takazhima N, Noma T, Yamada J. Inhibitory Effects of the 5-HT1A Receptor Agonist Buspirone on Stress-Induced Hyperglycemia in Mice: Involvement of Insulin and a Buspirone Metabolite, 1-(2-Pyrimidinyl) piperarazine (1-pp). Biol Pharm Bull 2005;28(4) 733-5.

  68. Sumiyoshi T, Ichikawa J, Meltzer H. The effect of streptozotocin induced diabetes on dopamine2, serotonin1A and serotonin 2A receptors in the rat brain. Neuropsyco-pharmacol 1996;16(3):1983-90.

  69. Sandrini M, Vitale G, OTAN A, Bertolini A. Streptozotocin-induced diabetes provokes changes in serotonin concentration and on 5-HT1A and 5-HT2 receptors in the rat brain. Life Sci 1997;60:1393-7.

  70. Thorre K, Chaouloff F, Sarre S, Meeusen R, Ebinger G, Michotte Y. Differential effects of restraint stress on hippocampal 5-HT metabolism and extracellular levels of 5-HT Streptozotocin-diabetic rats. Brain Res 1997;772:209-12.

  71. Barber M, Kasturi BS, Austin ME, Patel KP, MohanKumar SM, MohanKumar PS. Diabetes-induced neuroendocrine changes in rats: role of brain monoamines, insulin and leptin. Brain Res 2003;964(21):128-35.




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