2003, Number 3
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Perinatol Reprod Hum 2003; 17 (3)
Morbilidad del hijo de madre hipertiroidea en una institución de tercer nivel
Arroyo-Cabrales LM, Romero-Maldonado S, Delgado-Becerra A, Martínez-García H
Language: Spanish
References: 22
Page: 160-168
PDF size: 144.85 Kb.
ABSTRACT
Introduction: Hyperthyroidism is the second most frequent endocrine disease after diabetes
mellitus that presents itself during pregnancy. It occurs in two out of every 1,000 pregnancies.
The newborns may be hypo, hyper or euthyroid.
Objective: To determine the morbility of the infants born to mother’s with hyperthyroidism
and the mother’s general condition.
Material and methods: With a simple cohort, we accomplished an observational, retrospective
study, in a institutional facility, where we studied both maternal and neonatal variables.
We used central tendency and frequency measurements.
Results: In our study we included 141 hyperthyroid mothers, with an incidence of 0.5%, from
which 90.8% corresponded to Graves Disease. 71.8% were treated with methamizol. The
mayority of the deliveries were by cesarean. The average gestational age was: 37.6 ± 2.2
weeks, weight: 2794 ± 636 grams. We did neonatal screening on 126 patients and thyroid
fuction tests on 48. 7 patients were positive for congenital hyperthyroidism (5%), and 2 for
hypothyroidism (1.4%). 13 (9.2%) newborns presented some clinical data which was attributed
to a thyroid disorder.
Conclusions: The incidence of hyperthyroid mothers was of 0.48%. Graves Disease being
the etiology in 90.8% of the cases. Congenital hyperthyroidism was found in 5%, the predominant
symptoms were tachycardia and irritability.
REFERENCES
Mestman JH. Hyperthyroidism in pregnancy. Endocrinol Metab Clin North Am 1998; 27: 127-49.
Zimmerman D. Fetal and neonatal hyperthyroidism. Thyroid 1999; 9: 727-33.
Instituto Nacional de Perinatología. Normas y Procedimientos de Neonatología. Problemas Tiroideos. México, DF: 1998: p. 238-40
4 . Seely BL, Burrow GN. Thyroid disease and pregnancy. In: Creasy RK, Resnik R. Maternal-fetal medicine: principles and practice. 3th. ed. Philadelphia: WB Saunders Company; 1994: p. 979-1003.
Gallagher MP, Schachner HC, Levine LS Fisher DA, Berdon WE, Oberfield SE. Neonatal enlargement associated with propylthiouracil therapy of Graves’ disease during pregnancy: a problem revisited. J Pediatr 2001; 139: 896-900.
Polak M. Hyperthyroidism in early infancy: patogenesis, clinical features and diagnosis with a focus on neonatal hyperthiroydism. Thyroid 1998; 8: 1171-7.
Mestman JH. Diagnosis and management of maternal and fetal thyroid disorders. Curr Opin Obstet Gynecol 1999; 11: 167-75.
Lieutaud H. Pregnancy and the thyroid gland. Ann Med Interne 1999; 150: 397-407.
Davis LE, Lucas MJ, Hankins GDV Ruarte ML, Cunnigham FG. Thyrotoxicosis complicating pregnancy. Am J Obstet Gynecol 1989; 160: 63-70.
Glinoer D. Thyroid hyperfunction during pregnancy. Thyroid 1998; 8: 859-64.
Gittoes NJ, Franklyn JA. Hyperthyroidism. Current treatment guidelines. Drugs 1998; 55: 543-53.
Masiukiewicz US, Burrow GN. Hyperthyroidism inpregnancy: diagnosis and treatment. Thyroid 1999; 9: 647-52.
Abbott J, Mellum S. Aborto espontáneo. En: Frederickson HL, Wilkins-Haug L. Secretos de la Obstetricia. 2a. Ed. México, D.F.: Mc Graw–Hill Interamericana Editores; 1999, p. 64-8.
Johnson J. Enfermedad de la tiroides en el embarazo. En: Frederickson HL, Wilkins- Haug L. Secretos de la Obstetricia. 2a. Ed. México, DF: Mc Graw–Hill Interamericana Editores; 1999; p. 224-6.
Mortimer RH, Cannell GR, Addison RS, et al. Methimazole and propylthiouracil equally cross the perfused human term placental lobule. J Clin Endocrinol Metab 1997; 82: 3099-102.
Hernández MTH, Pérez Rulfo AC, Espinosa de los Monteros MA. Hipertiroidismo y embarazo. Ginecol Obstet Mex 1983; 51: 297-300.
Bruner JP, Dellinger EH. Antenatal diagnosis and treatment of fetal hyperthyroidism. A report of two cases. Fetal Diagn Ther 1997; 12: 200-4.
Mitsuda N, Tamaki H, Amino N et al. Risk factors for developmental disorders in infants born to women Graves disease. Obstet Gynecol 1992; 80: 359-64.
Rodríguez GR. Agenesia renal bilateral (síndrome de Potter) en hija de madre hipertiroidea que recibió metimazol durante el embarazo temprano. Ginecol Obstet Mex 1999; 67: 587-9.
Llano RI, García-Cavazos C, Hernández JO. Genetic analysis and counseling of congenital defects at the National Institute of Perinathology in Mexico City. Am J Hum Genet 2000; 67 (Supl. 2): 418.
González PA, Espinoza de los Monteros MA, Reynoso E. Tiroxina y tirotropina séricas en el recién nacido sano. Bol Med Hosp Infant Mex 1984, 41: 515-8.
Loechner KJ, Levitsky LL. Thyroid Disorders. In: Burg FC, Ingelfinger JR, Wald ER, Polin RA. Gellis & Kagan’s Current Pediatric Therapy 16. Philadelphia: W.B. Saunders Company; 1999, p. 736-42.