Mayorga J, Vergara A, Guillén MA, Escudero I

Language: Spanish
References: 15
Page: 158-164
PDF size: 106.54 Kb.

ABSTRACT

Introduction: Obesity is a global health problem and Mexico has the second and third highest prevalence of obesity in women and men, respectively. Obesity is associated with a high mortality rate, mostly from cardiovascular causes, which in turn result from accelerated atherosclerosis. It has been shown in the last decade that microalbuminuria constitutes an independent risk factor for macrovascular disease in both diabetic and non-diabetic populations. Objective: In order to evaluate the prevalence of microalbuminuria and its relationship with other cardiometabolic variables, we perform this cross-sectional, prospective and comparative study in an obese population. Design and methods: We pre-screened 162 subjects with obesity and overweight, of which 59 were finally included in the study. Besides clinical, biochemical, and anthropometric parameters (BP, abdominal perimeter, BMI, etc.) microalbumin excretion in 24-hour urine specimens was determined, as well as serum glucose and insulin to perform HOMA analysis and calculate insulin sensitivity indexes. Results: Microalbuminuria was found in 16% of the patients and its presence correlatedpositively with serum insulin levels, insulin resistance and BMI. However, when insulin resistance occurred along with a BMI › 30 and an abdominal girth > 90 cm, the risk of having microalbuminuria was not increased. Conclusion: This unselected Mexican obese population shows a prevalence of microalbuminuria similar to what has been reported in other parts of the World.

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