2007, Number 4
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Perinatol Reprod Hum 2007; 21 (4)
Obesity in Pregnancy: Maternal and neonatal effects
King JC, Casanueva E
Language: English
References: 54
Page: 210-217
PDF size: 84.59 Kb.
ABSTRACT
In the 21
st Century, obesity has become a world-wide epidemic. In Mexico, about 75% of non-pregnant women of reproductive age (between 20-49 years of age) are overweight or obese (body mass index › 25). In the USA, over 60% are overweight or obese. Overweight and obese women are more likely to gain excessively during pregnancy, and they are more likely to maintain excess weight after delivery. This weight gain also has implications for the child’s future risk of being overweight. In this paper, we will review the impact of maternal adiposity on reproduction, the effect of obesity on maternal metabolism and complications in pregnancy, the short and long-term effects on the infant, and potential interventions for alleviating poor outcomes.
REFERENCES
Olson CM, Strawderman MS, Reed RG. Efficacy of an intervention to prevent excessive gestational weight gain. Am J Obstet Gynecol 2004; 191: 530-6.
Oken E, Taveras EM, Kleinman KP, Rich-Edwards JW, Gillman MW. Gestational weight gain and child adiposity at age 3 years. Am J Obstet Gynecol 2007; 196: 322 e1-8.
Ahima RS, Flier JS. Leptin. Ann Rev Physiol 2000; 62: 413-37.
Watve MG, Yajnik CS. Evolutionary origins of insulin resistance: a behavioral switch hypothesis.BMC Evol Biol 2007; 17; 7: 61.
Schneider D, Zhou D, Blum RH. Leptin and metabolic control of reproduction. Horm Behav 2000; 37: 306-26.
Ramsay JE, Greer I, Sattar N. Obesity and reproduction. BMJ 2006; 333:1159-62.
Rich-Edwards JW, Goldman MB, Willett WC,Hunter DJ, Stampfer MJ, Colditz GA, Manson JE. Adolescent body mass index and infertility caused by ovulatory disorder. Am J Obstet Gynecol 1994; 171: 171-7.
Waller D, Daawson T. Relationship between maternal obesity and adverse pregnancy outcomes. In: Hornstra G, Uauy R, Yang X (eds) The impact of maternal nutrition on the offspring. Karger, Basel; 2005, p. 197-212.
Andreasen KR, Andersen ML, Schantz AL. Obesity and pregnancy. Acta Obstet Gynecol Scand 2004; 83: 1022-9.
Castro LC, Avina RL. Maternal obesity and pregnancy outcomes. Curr Opin Obstet Gynecol 2002; 14: 601-6.
Catalano PM. Management of obesity in pregnancy. Obstet Gynecol 2007; 109: 419-33.
Lashen H, Fear K, Sturdee D. Obesity is associated with increased first trimester and recurrent miscarriage: matched case-control study. Hum Reprod 2004; 19: 1644-6.
Fedorcsak P, Storeng R, Dale PO, Tanbo T, Abyholm T. Obesity is a risk factor for early pregnancy loss after IVF or ICSI. Acta Obstet Gynecol Scand 2000; 79: 43-8.
Merhi Z. Weight loss by bariatric surgery and subsequent fertility. Fertil Steril 2007; 87: 430- 2.
Grundy S. Obesity, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 2004; 89: 2595-600.
Baeten J, Bukusi E, Lambe M. Pregnancy complications and outcomes among overweight and obese nulliparous women. Am J Public Health 2001; 91: 436-40.
Chu SY, Callaghan WM, Kim SY, Schmid CH, Lau J, England LJ, Dietz PM. Maternal obesity and risk of gestational diabetes mellitus: A meta-analysis. Diabetes Care 2007; 30: 2070-6. Epub 2007 Apr 6.
Barbour LA. New concepts in insulin resistance of pregnancy and gestational diabetes: long-term implications for mother and offspring. J Obstet Gynaecol 2003; 23: 545-9.
Kirwan JP, Hauguel-de Mouzon S, Lepercq J, Challier J-C, Huston-Presley L, Friedman JE, Kalhan S, Catalano PM. TNF-a is a predictor of insulin resistance in human pregnancy. Diabetes 2002; 51: 2207-13.
King JC. 2007 Maternal obesity, glucose intolerance, and inflammation in pregnancy. In: Sies H (ed.). 2007; in press.
King JC. Maternal Obesity, Metabolism, and Pregnancy Outcomes. Annu Rev Nutr 2006; 26: 271-91.
Jovanovic-Peterson L, Peterson CM. Exercise and the nutritional management of diabetes during pregnancy. Obstetrics and Gynecology Clinics 1996; 23: 76-87.
Sheard N, Clark N, Brand-Miller J, Franz M, Pi-Sunyer F, Mayer-Davis E, Kulkarni K, Geil P. Dietary carbohydrate (amount and type) in the prevention and management of diabetes. Diab Care 2004; 27: 2266-71.
Fraser RB, Ford FA, Lawrence GF. Insulin sensitivity in third trimester pregnancy. A randomized study of dietary effects. Br J Obstet Gynaecol 1988; 95: 223-9.
Fraser RB, Ford FA, Milner RD. A controlled trial of a high dietary fibre intake in pregnancy– effects on plasma glucose and insulin levels. Diabetologia 1983; 25: 238-41.
Clapp JF, 3rd. Maternal carbohydrate intake and pregnancy outcome. Proc Nutr Soc 2002;61: 45-50.
Clapp JF, 3rd. Effect of dietary carbohydrate on the glucose and insulin response to mixed caloric intake and exercise in both nonpregnant and pregnant women. Diab Care 1998; 21: B107-12.
Zhang C, Liu S, Solomon CG, Hu FB. Dietary fiber intake, dietary glycemic load, and the risk for gestational diabetes mellitus. Diabetes Care 2006; 29: 2223-30.
Wang Y, Storlien LH, Jenkins AB, Tapsell LC, Jin Y, Pan JF, Shao YF, Calvert GD, Moses RG, Shi HL, Zhu XX. Dietary variables and glucose tolerance in pregnancy. Diabetes Care 2000; 23: 460-4.
Bo S, Menato G, Gallo ML, Bardelli C, Lezo A, Signorile A, Gambino R, Cassader M, Massobrio M, Pagano G. Mild gestational hyperglycemia, the metabolic syndrome and adverse neonatal outcomes. Acta Obstet Gynecol Scand 2004; 83: 335-40.
Clapp JF, 3rd, Kiess W. Effects of pregnancy and exercise on concentrations of the metabolic markers tumor necrosis factor alpha and leptin. Am J Obstet Gynecol 2000; 182: 300-6.
Dye TD, Knox KL, Artal R, Aubry RH, Wojtowycz MA. Physical activity, obesity, and diabetes in pregnancy. Am J Epidemiol 1997; 146: 961-5.
Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol 2003; 102: 181-92.
Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AH. Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomized placebo-controlled trial. Lancet 2006; 367: 1145-54.
Rumbold AR, Crowther CA, Haslam RR, Dekker GA, Robinson JS. 6 Vitamins C and E and the risks of preeclampsia and perinatal complications. N Engl J Med 2006; 354: 1796-806.
Hofmeyr GJ, Atallah AN, Duley L. Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2006;3: CD001059.
Duley L, Henderson-Smart D, Meher S. Altered dietary salt for preventing pre-eclampsia, and its complications. Cochrane Database Syst Rev 2005; CD005548.
Abrams BF, Laros RK, Jr. Prepregnancy weight, weight gain, and birth weight. Am J Obstet Gynecol 1986; 154: 503-9.
Abrams B, Parker JD. Maternal weight gain in women with good pregnancy outcome. Obstet Gynecol 1990; 76: 1-7.
Weiss JL, Malone FD, Emig D, Ball RH, Nyberg DA, Comstock CH, Saade G, Eddleman K, Carter SM, Craigo SD, Carr SR, D’Alton ME. Obesity, obstetric complications and cesarean delivery rate—a populationbased screening study. Am J Obstet Gynecol 2004; 190: 1091-7.
Vahratian A, Zhang J, Troendle JF, Savitz DA, Siega-Riz AM. Maternal prepregnancy overweight and obesity and the pattern of labor progression in term nulliparous women. Obstet Gynecol 2004; 104: 943-51.
James AH, Jamison MG, Brancazio LR, Myers ER. Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality. Am J Obstet Gynecol 2006; 194: 1311-5.
Bodnar LM, Siega-Riz AM, Cogswell M. High prepregnancy BMI increases the risk of postpartum anemia. Obes Res 2004; 12:941-8.
Noussitou P, Monbaron D, Vial Y, Gaillard R, Ruiz J. Gestational diabetes mellitus and the risk of metabolic syndrome: a populationbased study in Lausanne, Switzerland. 2005;31: 361-9.
Ehrenberg HM, Mercer BM, Catalano PM. The influence of obesity and diabetes on the prevalence of macrosomia. Am J Obstet Gynecol 2004; 191: 964-8.
Catalano P, Ehrenberg H. The short- and long-term implications of maternal obesity on the mother and her offspring. BJOG 2006;113: 1126-33.
Gillman MW, Rifas-Shiman S, Berkey CS, Field AE, Colditz GA. Maternal gestational diabetes, birth weight, and adolescent obesity. Pediatrics 2003; 111: e221-6.
Li C, Kaur H, Choi WS, Huang TT, Lee RE, Ahluwalia JS. Additive interactions of maternal prepregnancy BMI and breast-feeding on childhood overweight. Obes Res 2005; 13:362-71.
Whitaker RC. Predicting preschooler obesity at birth: the role of maternal obesity in early pregnancy. Pediatrics 2004; 114: e29-36.
Vohr BR, McGarvey ST, Tucker R. Effects of maternal gestational diabetes on offspring adiposity at 4-7 years of age. Diabetes Care 1999; 22: 1284-91.
Boney C, Verma A, Tucker R, Vohr B. Metabolicsyndrome in childhood: association with birth weight, maternal obesity, and gestational diabetes mellitus. Pediatrics 2005; 115: e290-6.
Harder T, Bergmann R, Kallischnigg G, Plagemann A. Duration of breastfeeding and risk of overweight: a meta-analysis. Am J Epidemiol 2005; 162: 397-403.
Rasmussen KM. Association of Maternal Obesity before Conception with Poor Lactation Performance. Annu Rev Nutr 2007; 27: 103-21.
Rising R, Lifshitz F. Relationship between maternal obesity and infant feeding-interactions. Nutr J 2005; 4: 17.