Gómez GA, Magaña GP

Language: Spanish
References: 53
Page: 342-352
PDF size: 143.50 Kb.

ABSTRACT

Trace elements are defined as nutrients that the human body needs in concentrations of one part per 1 000 000 and comprise ‹ 0.01 % of total body weight. An element is considered essential if a dietary deficiency of that element results in suboptimal biological function that is preventable or reversible by ingestion of this element. Certain alterations in insulin secretion and actions can be related with a decrease in chromium (Cr) or zinc (Zn) levels. In this paper, we described chemical characteristics, biological role, and mechanism of action of both elements for regulation of insulin secretion and expression, or activity of insulin receptor for better efficacy of insulin. Cr and Zn demonstrate action on basic cellular reactions of carbohydrates, lipids, protein metabolism, and energy production. These elements influence development and progression of diabetes mellitus and high blood pressure. This review highlights the evidence and the association that both trace elements have on insulin action.

REFERENCES

1. 1. Taylor A. Detection and monitoring of disorders of essential trace elements. Ann Clin Biochem 1996;33: 486-510.

2. 2. Nielsen FH. Ultratrace elements in nutrition. Ann Rev Nutr 1984;4:21-41.

3. 3. Greger JL. Mineral bioavailability/new concepts. Nutr Today 1987;22:4-9.

4. 4. Kahn CR. Current concepts of the molecular mecha-nism of insulin action. Ann Rev Med 1985;36:429-451.

5. 5. Roth RA, Lui F, Chin JE. Biochemical mechanism of insulin resistance. Hormone Res 1994;41(Suppl 2): 51-55.

6. 6. Davis CM, Sumall KH, Vincent JB. A biologically active form of chromium may activate a membrane phosphotyrosine phosphatase (PTP). Biochemistry 1996;35:12963-12969.

7. 7. Ping L, Elmendorf J. Changes in plasma membrane architecture as a basis for chromium-activated GLUT traslocation. Diabetes 2003;52(S1):A532.

8. 8. Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17(6):548-555.

9. 9. Baumgartner TG. Trace elements in clinical nu-trition. NCP 1993;8(6):251-263.

10. O’Connell BS. Selected vitamins and minerals in the management of diabetes. Diabetes Spectrum 2001;14(3):133-148.

11. Sing RB, Niaz MA, Rastogi SS, Bajaj S, Gaoli Z, Shoumin Z. Current zinc intake and risk of diabetes and coronary artery disease and factors associated with insulin resistance in rural and urban populations of North India. J Am Coll Nutr 1998;17(6): 564-570.

12. Lukaski HC. Chromium as a supplement. Annu Rev Nutr 1999;19:279-302.

13. Jeejeebhoy KN. The role of chromium in nutrition and therapeutics and as a potential toxin. Nutr Rev 1999;57(11):329-335.

14. Dowling H, Offenbacher E, Pi-Sunyer X. Effects of aminoacids on the absortion of trivalent chromium and its retention by regions of the rat small intestine. Nutr Res 1990;10:1261-1271.

15. Seaborn C, Stoecker B. Effects of antacid ascorbic acid on tissue accumulation and urinary excretion of Cr51 chromium. Nutr Res 1990;10:1401-1407.

16. Mertz W. Is chromium essential for humans? Nutr Rev 1988;46:17-20

17. Striffer J, Polansky M, Anderson R. Dietary chro-mium enhances insulin secretion in perfused rat pancreas. J Trace Elem Exper Med 1993;6:75-81.

18. Yamamoto A, Wada O, Suzuki H. Purification and properties of biological active chromium complex from bovine colostrum. J Nutr 1988;118:39-45.

19. Vincent JB. The biochemistry of chromium. J Nutr 2000;130:715-718.

20. Vincent JB. Mechanism of chromium action: low-molecular-weight chromium-binding substance. J Am Coll Nutr 1999;18(1):6-12.

21. Mertz W. Effects and metabolism of glucose to-lerance factor. Nutr Rev 1975;33:129-135.

22. Davis C, Vincent J. Chromium oligopeptide activates insulin receptor kinase activity. Biochemistry 1997; 36:4382-4385.

23. Roth R, Lui F, Chin J. Biochemical mechanism of in-sulin resistance. Hormone Res 1994;41(Suppl 2):51-55.

24. Anderson R. Nutritional factors influencing the glucose/insulin system: chromium. J Am Coll Nutr 1997;16:404-410.

25. Thomas V, Gropper S. Effect of chromium nicotinic acid supplementation on selected cardiovascular dis-ease risk factors. Biol Trace Elem Res 1996;55:297-305.

26. Anderson R, Polasky M, Bryden N, Canary J. Supplemental chromium effects on glucose, insulin, glucagon, and urinary chromium losses in subjects consuming controlled low chromium diets. Am J Clin Nutr 1991;54:909-916.

27. Juturu V, Komorowski JR. Chromium: a systematic overview and metaanalysis. Diabetes 2002;51(S2):A488.

28. Mertz W. Chromium levels in serum, hair, and sweat decline with age. Nutr Rev 1997;55:373-375.

29. Groff JL, Gropper SS. Microminerals. En: Groff JL, Gropper SS, editors. Advanced nutrition and human metabolism. Third edition. Belmont CA: Wadsworth/Thomson Learning; 2000. p. 401-469.

30. Hunt J, Matthys L, Johnson L. Zinc absorption, mineral balance, and blood lipids in women consuming controlled lactoovovegetarian and omnivorous diets for 8 week. Am J Clin Nutr 1998;67:421-430.

31. King JC. Shames DM, Woodhouse LR. Zinc homeostasis in humans. J Nutr 2000;130:1360S-1366S.

32. Lonnerdal B. Dietary factors influencing zinc ab-sorption. J Nutr 2000;130:1378S-1383S.

33. McCall KA, Huang Ch, Fierke CA. Function and mechanism of zinc metalloenzymes. J Nutr 2000; 130:1437S-1446S.

34. Black RE. Zinc deficiency, infections disease and mortality in the developing world. J Nutr 2003;133: 1485S-1489S.

35. O’Dell BL. Role of zinc in plasma membrane func-tion. J Nutr 2000;130:1432S-1436S.

36. Chen MD, Chen MD, Lin PY, Chen PS, Cheng V, Lin WH. Zinc attenuation of GDP binding to brown adipocytes mitochondria is genetically obese (ob/ob) mice. Biol Trace Elem Res 1997;57(2):139-145.

37. Klaus-Helge I, Lothar R. Zinc-altered immune function. J Nutr 2003;133:1452S-1456S.

38. MacDonald RS. The role of zinc in growth and cell proliferation. J Nutr 2000:1500S-1508S.

39. Chausmer AB. Zinc, insulin and diabetes. J Am Coll Nutr 1998;17(2):109-115.

40. Arquilla ER, Thiene P, Brugman T, Ruess T, Sugiyama R. Effects of zinc ion on the conformation of antigenic determinants on insulin. Biochem J 1978; 178:289-297.

41. Hendricks DG, Mahoney AW. Glucose tolerance in zinc deficient rats. J Nutr 1972;102:1079-1084.

42. Huber AM, Gershoff SN. Effect of zinc deficiency in rats on insulin release from the pancreas. J Nutr 1973;103:1739-1744.

43. Chen MD, Lin WH, Lin PY, Wang JJ, Tsou CT. Investigation on the relationships among blood zinc, copper, insulin and thyroid hormones in non-insulin diabetes mellitus and obesity. Chung Hua I Hsueh Tsa Chih (Taipei) 1991;48(6):431-438.

44. Begin-Heick N, Dalpe-Scott M, Rowe J, Heick HM. Zinc supplementation attenuates insulin secretory activity in pancreatic islets of the ob/ob mouse. Diabetes 1985;34(2):179-84.

45. El-Yazigi A, Hannan N, Raines D. Effect of diabetic state and related disorders on the urinary excretion of magnesium and zinc in patients. Diabetes Res 1993;22:67-75.

46. Quaterman J, Mills C, Humphries W. The reduced secretion of sensitivity to insulin in zinc deficient rats. BBRC 1966;25:354-358.

47. Boquist L, Falkmer S, Havu N, Pihl E. Insulin bio-synthesis, storage and secretion: pancreatic islet cells and islet cells. Lakartindningen 1968;35:3603-3607.

48. Brand IA, Kleineke J. Intracellular zinc movement and its effect on the carbohydrate metabolism of isolated rat hepatocytes. J Biol Chem 1996;271(4): 1941-1949.

49. Díaz-Zagoya J, Hicks-Gómez JJ. Bioquímica. Segunda edición. México: Interamericana-McGraw-Hill; 1995. p. 203-253.

50. Strain J. Disturbances of micronutrient and antioxi-dant status in diabetes. Proc Nutr Soc 1991;50:591-604.

51. Faure P, Benhamou PY, Perard A, Halimi S, Roussel AM. Lipidperoxidation in insulin-dependent diabetic patients with early retina degenerative lesions: effects of an oral zinc supplementation. Eur J Clin Nutr 1995;49:282-288.

52. Szaaleczky E, Prechl J, Fehér J, Somogyi A. Altera-tions in enzymatic antioxidant defence in diabetes mellitus a rational approach. Postgrad Med J 1999; 75:13-17.

53. Wood RJ. Assessment of marginal zinc status in humans. J Nutr 2000;130:1350S-1354S.