2009, Number 1
<< Back Next >>
Cir Cir 2009; 77 (1)
Experiencia quirúrgica en el adenocarcinoma de uraco
Martínez-Cornelio A, Flores-López D, Flores-Ojeda R, Quintero-Becerra J, Hernández-Toriz N
Language: Spanish
References: 28
Page: 33-38
PDF size: 167.97 Kb.
ABSTRACT
Background: Urachal carcinomas are rare neoplasms that constitute ‹1% of bladder tumors. We undertook this study to describe the medical and surgical experience of urachal carcinomas treated in our hospital.
Methods: We carried out a retrospective, descriptive and observational study. Clinical files were reviewed of patients with diagnosis of bladder cancer and who were operated on with radical cystectomy with urinary substitution and extended partial cystectomy, selecting those patients with pathological report of urachal carcinoma. The study was conducted from January 1994 to May 2007 analyzing the following data: age, sex, symptoms, diagnostic methods, surgical approach, complications and disease-free survival.
Results: Of the 306 patients operated on with radical surgery for bladder cancer, only five patients (1.6%) had a diagnosis of urachal carcinoma. There were three (60%) men and two (40%) women, with a median age of 61 years. Hematuria was the chief complaint in all cases and the reason why they were initially treated with ultrasonography (USG). In one case, tumor of the right ovary was documented and the patient underwent exploratory laparotomy and extended partial cystectomy. In the other four cases, tumor was reported in the dome of the bladder and for this reason cystoscopy and transurethral resection of the bladder (TURB) were done, confirming the clinical findings in addition to the pathology report suggesting urachal carcinoma. Computed tomography (CT) confirmed the tumor in urachal topography, reporting a Sheldon clinical stage IIIb in three patients and stage IVa in one patient. This was the reason for the Studer-type orthotopic bladder substitution. Currently, four patients are being followed-up without recurrence, reporting only one death related to the disease.
Conclusions: Urachal carcinomas are rare tumors with an incidence of 1.6% in our studied population. Symptoms in most cases are similar to those of bladder pathology origin. The surgical approach and procedure described here provide the best opportunity for disease-free survival.
REFERENCES
Hue L, Jacquin M. Cancer collide de la lombile et de paroi abdominale anterieure Ayant envai la vessi. Union Med de la Siene Inf Rouen 1863;6:418-420.
Sheldon CA, Clayman RV, González R, Williams R, Fraley EF. Malignant urachal lesions. J Urol 1984;131:1-8.
3.Herr HW, Bochner BH, Sharp D, Dalbagni G, Reuter VE. Urachal carcinoma: contemporary surgical outcomes. J Urol 2007;178:74-78.
Kakizoe T, Matsumoto K, Andoh M, Nishio Y, Kishi K. Adenocarcinoma of urachus: report of 7 cases and review of literature. Urology 1983;21:360-366.
Henly DR, Farrow GM, Zincke H. Urachal cancer: role of conservative surgery. Urology 1993;42:635-639.
Pode D, Fair WR. Urachal tumors. AUA Update Series 1991;10:34.
Kawakami S, Kageyama Y, Yonese J, Fukui I. Kitahara S, Arai G, et al. Successful treatment of metastatic adenocarcinoma of the urachus: report of 2 cases with more than 10 year survival. Urology 2001;58:462.
Kojima Y, Yamada Y, Kamisawa H, Sasaki S, Hayashi Y, Kohri K, et al. Complete response of a recurrent advanced urachal carcinoma treated by S-1/Cisplatin combination chemotherapy. Int J Urol 2006;13:1123-1125.
Ojea C, Núñez L, Domínguez F, Alonso R. Adenocarcinoma mucinoso del uraco. Actas Urol Esp 2003;27:142-146.
Kise H, Kanda H, Hayashi N, Arima K, Yanagawa M. Kawamura J. Alphafetoprotein producing urachal tumor. J Urol 2000;163:547.
Rubin JP, Kasznica JM, Davis CA, Carpinito GA, Hirschf EF. Transitional cell carcinoma in a urachal cyst. J Urol 1999;162:1687-1688.
12.Chow YC, Lin WC, Tzen CY, Chow YK, Lo KY. Squamous cell carcinoma of the urachus. J Urol 2000;163:903-904.
Pinthus JH, Haddad R, Trachtenberg JT, Holowaty E, Bowler J, Herzenberg AM, et al. Population based survival data on urachal tumors. J Urol 2006;175:2042-2047.
Siefker-Radtke AO, Gee J, Shen Y, Wen S, Daliani D, Millikan RE, et al. Multimodality management of urachal carcinoma: The M.D. Anderson Cancer center experience. J Urol 2003;169:1296-1298.
Pantuck AJ, Bancila E, Das KM, Amenta PS, Cummings KB, Marks M, et al. Adenocarcinoma of the urachus and bladder expresses unique colonia epithelium epitope: an immunohistochemical study. J Urol 1997;158:722-727.
Nobuyuki K, Shinji U, Dazushi S, Hiroaki S, Midio I. Urachal carcinoma associated with increased carbohydrate antigen 19-9 and carcinoembryonic antigen. J Urol 2001;166:604.
Lertprasertsuke N, Tsutsumi Y. Alpha-fetoprotein producing urachal adenocarcinoma. Acta Pathol J 1991;41:318-326.
Cooperman L. Carcinoma of the urachus with extensive abdominal calcification. Urology 1978;12:614-616.
Brick S, Friedman A, Pollack H. Urachal carcinoma: CT findings. Radiology 1988;169:377-381.
Narumi Y, Sato Y, Kuriyama K. Vesical dome tumors significance of extravesical extension on CT. Radiology 1988;169:383-385.
Krydewicz S. Diagnosis of urachal carcinoma by computed tomography and magnetic resonance imaging. Clin Imaging 1990;14:251-254.
Wheeler J, Will H. Adenocarcinoma involving the urinary bladder. Cancer 1954;7:119-134.
Ashley RA, Inman BA, Sebo TJ, Leibovich BC, Blute ML, Kwon ED, et al. Urachal carcinoma: clinicopathologic features and long-term outcomes of an aggressive malignancy. Cancer 2006;107:712-720.
Brion P, Lefebyre Y, Neve R. Adenocarcinoma de Iöuraque: analyse de 3 cas progres. Urology 2002;12:96-101.
Porpiglia F, Cracco C, Terrone C, Cossu M, Renard J, Billia M, et al. Combined endoscopic and laparoscopic en bloc resection of the urachus and the bladder dome in a rare case of urachal carcinoma. Int J Urol 2007;14:362-364.
Ohira S, Shiohara S, Itoh K, Ashida T, Fukushima M, Konischi I. Urachal adenocarcinoma metastatic to the ovaries: case report and literature review. Int J Gynecol Pathol 2003;22:189-193.
Bastian H, Jensen E, Jylling A. Urachal carcinoma with metastasis to the maxilla: the first reported case. J Oral Pathol Med 2001;30:378-380.
28.Mostofi F, Thomson R, Dean A. Mucus adenocarcinoma involving the urinary bladder. Cancer 1995;8:741-758.