Martínez-Medina MA, Orozco-Cárdenas MB

Language: Spanish
References: 17
Page: 115-118
PDF size: 197.66 Kb.

ABSTRACT

Introduction: Deficiency in the production of thyroid hormones leads to congenital hypothyroidism (CH). CH is the most common treatable cause of mental retardation. Case Report: We review the case of newborn with CH. At 23 days of life a neonatal screening (NS) reported elevated thyroid stimulating hormone (TSH) in 119.3 µUI/ml. A confirmatory serum test reported a low thyrosine (T4) and TSH elevated concentration. Treatment with replacement levothyroxine was initiated in dosage of 50 µg/day. Conclusion: Delay in diagnosis or suboptimal treatment of CH results in variable mental retardation. Currently, with NS, pediatricians and neonatologists can prevent it with early detection and appropriate L-thyroxine hormone

REFERENCES

1. Lafranchi S. Hypothyroidism. En Nelson. Textbook of Pediatrics. Eds. Behrman RE, Kliegman RM, Jenson HB. 16th.W.B. Saunders Co. 2000: 1698-704.

2. Barrón Uribe C. Conceptos actuales de hipotiroidismo congénito derivados del tamiz neonatal. Curso de actualidades en endocrinología, Hospital Angeles del Pedregal, México, D.F., 2000.

3. Setian N. Hypothyroidism in children. Diagnosis and treatment. J Pediatr (Rio J) 2007; 83: S 209-16.

4. LaFranchi SH, Austin J. How should we be treating children with congenital hypothyroidism ? J Pediatr Endocrinol Metab 2007, 20: 559-78.

5. Secretaría de Salud. Norma Técnica 321, para la Prevención del Retraso Mental producido por Hipotiroidismo Congénito.. México, D.F. Diario Oficial de la Federación, 22 de septiembre de 1988: 88-90.

6. Instituto Mexicano del Seguro Social. Detección y atención integral de las enfermedades metabólicas congénitas. México, D.F. 2007: 19.

7. Instituto Mexicano del Seguro Social. ENCOPREVENIMSS 2006: 39.

8. Gomela TL, Cunningham MD, Eyal FG, Zenk KE. Neonatología. 4ª ed. Panamericana, 2002: 651-2.

9. Vela-Amieva M, Gamboa-Cardiel S, Pérez-Andrade M, Ortiz-Cortés J, González-Contreras C, Ortega-Velásquez V. Epidemiología del hipotiroidismo congénito en México. Salud Pública Mex 2004; 46: 141-8.

10. Sánchez Pérez C, Calzada R, Ruiz R, Altamirano N, Méndez I, Vela AM y cols. Hipotiroidismo congénito. Manifestaciones clínicas en niños menores de 15 semanas con tamiz neonatal positivo. Rex Mex Pediatr 2006; 73: 272-9.

11. Alm J Larsson A, Zetterstrom R. Congenital hypothyroidism in Sweden. Incidence and age at diagnosis. Acta Paediatr Scan 1978; 67: 1-3.

12. Klein AH, Meltzer S, Kenny FM. Improved prognosis in congenital hypothyroidism treated before age three months. J Pediatr 1972; 81: 912-5.

13. American Academy Pediatrics. Section on Endocrinology and Committee on Genetics; American Thyroid Association. Update of newborn screening and therapy for congenital hypothyroidism. Pediatrics 2006; 117: 2290-303.

14. Selva K, Mandel SH, Rein L, Miyahira R, Skeels M, LaFranchi S. Inicitial treatment dose of l-thyroxine in congenital hypothyroidism. J Pediatr 2002: 141: 786-92.

15. Selva K, Harper A, Downs A, Blasco PA, LaFranchi SH. Neurodevelopmental outcomes in congenital hypothyroidism: comparison of initial T4 doses and time to reach target T4 and TSH. J Pediatr 2005; 147: 775-80.

16. Kreisner E, Schermann L, Camargo Neto E, Grass JL. Predictors of intellectual outcome in a cohort of brazilian children with CH. Clinical Endocrinology 2004; 60: 250-5.

17. Oerbeck B, Sundet K, Kase B, Heyerdahl S. Congenital hypothyroidism: influence of disease severity and lthyroxine treatment on intellectual, motor, and school-associated outcomes in young adults. Pediatrics 2003; 112: 923-30.