Medrano RJC, Yahuaca MP, Presno BM, Alvarado AJL

Language: Spanish
References: 21
Page: 319-326
PDF size: 372.05 Kb.

ABSTRACT

Background: Oxidative stress has been related to several conditions during pregnancy (preeclampsia, abortions and premature rupture of membranes); it causes higher sensitivity of the endothelial blood vessel constriction and aggravates the endothelium dependent vasodilatación.
Objetive: To determine the oxidative stress level and histological changes in preeclamptic women’s placenta. Patients and method: Longitudinal and comparative study. There were included 25 patients referred from second level health units (IMSS, ISSSTE and Hospital General de Zacatecas). To evaluate oxidative stress level, a sample of blood and placenta were obtained during delivery and a second sample was taken during mediate puerperium (10 days).
Results: In control group, total lipidic peroxide levels in serum were 135.6 ± 7.3 nmol of MDA/mL of serum, compared with the group of moderate hypertension, which registered 222.0 ± 35.15 nmol MDA/mL. Total lipidic peroxides in serum during puerperium for control group were 150.4 ± 30.8 and 183.3 ± 18.51 nmol MDA/mL for the group of moderate hypertension. Placental lipoperoxidation for control group was 0.40 ± 0.03 µg MDA/g, and of 0.32 ± 0.03 µg MDA/g for the group of mild hypertension. Patients of moderate hypertension group showed an increase at 34% on placental lipoperoxidation over control group. Placental histological alterations where characterized by vascular remodeling loss, deposits of proteinaceous material and macrophagic process.
Conclusion: Total lipidic peroxide levels in serum increases during preeclampsia. Histological changes refer uterus-placental ischemia that, probably, induces the oxidative stress.

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