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2008, Number 4

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Bioquimia 2008; 33 (4)

Evidence of lipidic microdomain existence in organelle membranes

Martínez-Abundis E, Zazueta-Mendizábal C

Language: Spanish
References: 56
Page: 164-170
PDF size: 113.68 Kb.


ABSTRACT

Although it is a controversial topic, the lipid microdomain theory has overcome the adverse opinions and finally its existence has been proved by diverse microscopy techniques. Currently, there is evidence with regard to this kind of membrane domains are in fact in the cell organelles such as the endoplasmatic reticulum, the Golgi complex, and the mitochondria and they are not restricted to the plasmatic membrane. In these organelles, the lipid domains could participate in important cell functions, e.g. protein sorting and delivering, protein retention, cholesterol transport between cell compartments, vesicle formation and death signaling with mitochondrion participation. There is still a great deal of research to do in order to reach a solid theory of organelle-lipid domains, principally because, in some of those organelles, cholesterol and sphingolipids, that are important to build and stabilize lipid membranes, are present at lower concentrations. However, it is an interesting topic of research that will contribute with important information in the coming years. The purpose of this review is enlisting the recent evidence about the existence and the probable functions of lipid rafts in the cell organelles.


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