Martínez-Abundis E, Zazueta-Mendizábal C

Idioma: Español
Referencias bibliográficas: 56
Paginas: 164-170
Archivo PDF: 113.68 Kb.

RESUMEN

La teoría de los microdominios lipídicos ha ganado terreno y finalmente se ha demostrado su existencia por diversas técnicas, aunque aún existen aspectos que resultan controvertidos. Actualmente, existe evidencia de que este tipo de dominios membranales se encuentra, además de en la membrana plasmática, en organelos tales como retículo endoplasmático, complejo de Golgi y mitocondrias. En estos organelos pueden participar en funciones tan importantes como la clasificación, distribución y retención de proteínas, en el transporte de colesterol, vesiculación y en la señalización de apoptosis que implica la intervención de las mitocondrias. Es cierto que aún falta mucho por investigar para dar una total credibilidad a esta teoría, sobre todo porque en algunos organelos como en el retículo endoplasmático y en las mitocondrias, las concentraciones de colesterol y glicoesfingolípidos –que son importantes para la formación y estabilidad de este tipo de membranas– son muy bajas, pero sin duda es un tema apasionante que promete resultados importantes en los próximos años. El propósito de esta revisión es hacer un recuento de la información generada hasta el momento sobre la presencia y posibles funciones de los microdominios lipídicos en las membranas de algunos organelos celulares.

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