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ISSN 1665-3254 (Print)
Revista Oficial de la Universidad Biomédica Rafael Guízar y Valencia A. C.

2004, Number 1-2

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Plasticidad y Restauración Neurológica 2004; 3 (1-2)

Clinical manifestation, incidence, and prognosis of Guillain-Barré syndrome in children

Lechuga PM, García RR, Aguilar RF, Sánchez VG, Rayo MD, Ramírez NE

Language: Spanish
References: 38
Page: 15-25
PDF size: 104.84 Kb.


ABSTRACT

Antecedents. Previous reports have suggested that outcome is worse in the axonal compared with the demyelinating form of Guillain-Barré syndrome (GBS)
Aid. Describe the clinical characteristics, incidence and prognosis with GBS in children.
Material and Methods. We performed a retrospective study with 42 children’s with electropysiologically confirmed cases. Nine cases of this were excluded for wrong diagnosis, and three of them for incomplete chart. The totally childs 30 were studied in the National Medical Center century XXI from Social security Mexican institute, by January first 1996 to December 31 2002.
Results. The mean of age 7.39 years and range were of 8 months to 15 years. The incidence was 0.77/100000. The patients were classified based on the electrodiagnostic features: Seventeen (58%) had acute inflammatory demyelinating polyradiculoneuropathy, thirteen (42%) had acute motor axonal neuropathy and five (21%) had acute motor-sensory axonal neuropathy. All patients received a standard intravenous immunoglobulin (IVIG) therapy (0.4 g/kg/day for 5 consecutive days). There was no significant difference at 6 months in GBS scores between demyelinating and axonal forms GBS. All 30 patients recovered completely by 12 months.
Discussion. The most important factors for influence over recovery gait were presence axonal patterns and severity Hughes V. After standard IVIG therapy, children with axonal forms of GBS recovery more slowly that those with the demyelinating form. Moreover, outcome at 12 months appears to be equally favorable in two groups.


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