medigraphic.com
Federación Mexicana de Ginecología y Obstetricia, A.C.

2007, Number 07

<< Back Next >>

Ginecol Obstet Mex 2007; 75 (07)

Estrogen therapy effect in arterial tension in postmenopausal women

Basavilvazo RMA, Roldán RJR, Lemus RR, Cruz CP, Zárate A, Hernández VM

Language: Spanish
References: 16
Page: 394-398
PDF size: 167.38 Kb.


ABSTRACT

ntroduction: Experimental studies have shown that estrogens prevent deposit of cholesterol in arteries, have effect upon the endothelial function (to prevent contraction of smooth muscle), and enlarge the vascular tone or vasodilatation.
Objective: To determine changes in arterial pressure before and after use of estrogen-therapy.
Material and methods: A descriptive study was carried out follow-up during 8 weeks in Obstetric and Gynecologic Hospital (No. 3), Instituto Mexicano del Seguro Social. We included 250 postmenopausal women with prescribed estrogen-therapy. Arterial tension was determined before and after therapy; descriptive statistics and student t test (value, p ‹0.05) was employed.
Results: Menopause was present in a mean of age of 46 ± 4.2 years (M ± SD); height was 1.53 ± 0.6 m; corporal weight, 60.9 ± 10.2 kg, and hip-waist index was 81.3 ± 5.4. Mean arterial tension before estrogen-therapy was 90.2 ± 10.0 mmHg, and after, 85.7 ± 9.6 mmHg (p ‹0.05).
Conclusions: There is evidence of estrogen-therapy vasodilatation and hypotension effects, with clinical changes statistically significative; however is recommendable that such estrogenic therapy must be individualized and attended in slender form. Hormonal therapy (estrogens) has benefits in arterial tension of postmenopausal women.


REFERENCES

  1. Pyorala K. Interpopulation correlations between serum cholesterol level and the occurrence of coronary heart disease. Eur Heart J 1987;8:23-26.

  2. Bush TL. The epidemiology of cardiovascular disease in postmenopausal women. Ann N Y Acad Sci 1990;592:263-71.

  3. Lozano-Ascencio R, Escamilla JA, Escobedo de la Peña J, López-Cervantes M. Tendencia de la mortalidad por cardiopatía isquémica en México, de 1950 a 1985. Salud Pública Méx 1990;32:405-14.

  4. Kannel WB, Hjortlann MC, McNamara PM, Gordon T. Menopause and risk of cardiovascular disease. The Framingham study. Ann Intern Med 1976,85:447-52.

  5. Walsh BW, Achiff I, Rosner B, Greenberg L, et al. Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. N England J Med 1991;325:1196-204.

  6. Sullivan JM, Vander ZR, Hughes JP, Maddock V, et al. Estrogen Replacement and coronary artery disease. Effect of survival in postmenopausal women. Arch Intern Med 1990;150:2557-62.

  7. Seed M. Postmenopausal hormone replacement therapy, coronary heart disease and plasma lipoproteins. Drugs 1994;47:25-34.

  8. Collins P, Jiang C, Shay J, Moss J. In vitro EDRF-dependent coronary artery relaxation to physiologic concentrations of 17-beta estradiol: modulation by in vivo sex hormone status. Circulation 1993;88(Suppl 1):1-79.

  9. Collins P, Rosano GMC, Adamopoulos S, McNeil J. Reversal of acetylcholine-induced vasoconstriction by intracoronary administration of estradiol-17b in menopausal women with coronary artery disease. Circulation 1993;88(Suppl 1):3168-3170.

  10. Guetta V, Panza JA, Waclawiw MA, Cannon RO. Effect of combined 17b-Estradiol and Vit E on low-density lipoprotein oxidation in postmenopausal women. Am J Cardiol 1995;75:1274-6.

  11. Rifici VA, Khachadurian AK. The inhibition of low-density lipoprotein oxidation by 17-beta estradiol. Metabolism 1992;41:1110-5.

  12. Tayebiee MH, Lee KW, Lip GY. Salt-loading and nitric oxide inhibition after the menopause. J Hypertens 2003;21:1255-7.

  13. Basurto L, Saucedo R, Ochoa A, Hernández-Valencia M, Zárate A. La terapia de reemplazo hormonal con estradiol transdérmico disminuye los niveles de insulina-cortisol y lipoproteínas en mujeres posmenopáusicas. Ginec Obst Mex 2002;70:491-5.

  14. Akhan SE, Gurel T, Has R, Iyibozkurt AC, Turfanda A. Effects of long-term oral hormone replacement therapy on plasma nitric oxide and beta-endorphin levels in postmenopausal women. Gynecol Obstet Invest 2002;54:196-200.

  15. Basurto L, Saucedo R, Zarate A, Martinez C, et al. Effect of pulsed estrogen therapy on hemostatic markers in comparison with oral estrogens regimen in postmenopausal women. Gynecol Obstet Invest 2006;61:61-64.

  16. Telci A, Cakatay U, Akhan SE, Bilgin ME, et al. Menopausal hormone replacement therapy use decreases oxidative protein damage. Gynecol Obstet Invest. 2002;54:88-93.




2020     |     www.medigraphic.com