Pérez MJJ, Robledo AM, Corona RJR, Alfaro AN, Castro HJF

Language: Spanish
References: 14
Page: 142-147
PDF size: 146.87 Kb.

ABSTRACT

Objective: To determine prevalence and maternal risk factors associated with preauricular tags.
Material and method: A case-control study of 254 newborns with isolated preauricular tags not considered part of a syndrome and their controls, and who were delivered at the Hospital Civil de Guadalajara Dr. Juan I. Menchaca between 1990 and 2003. The maternal risk factors were demonstrated by means of a direct interview with the mother.
Results: The prevalence of the isolated preauricular tags was 1.96 per 1,000 newborns alive, in a 1.2 men for each woman. The history of another affected relative was strongly associated with preauricular tags (OR 19.28; 95% CI: 4.44-117.60). Infants with preauricular tags frequently showed parents consanguinity (OR 3.04; 95% CI: 0.28-76.26), maternal age ≥35 years (OR 1.14; 95% CI: 0.53-2.48), exposure to some disease (OR: 1.23, 95% CI: 0.72-2.12), and drugs use in the first trimester of pregnancy (OR: 1.11; 95% CI: 0.65-1.92). No associations were found for the frequency of abortion, exposure to organic solvents and maternal occupation.
Conclusions: The prevalence of isolated preauricular tags in this population was similar to that reported in other regions of Latin America, but lower to the prevalences in Sweden and Israel. This malformation has an important hereditary component; however, it is probably that some teratogenic factors, such as diabetes mellitus, can increase its frequency.

REFERENCES

1. O'Rahilly R, Müller F. Human embryology & teratology. 3a ed. New York: Wiley-Liss, 2001;pp:480-6.

2. Sadler TW. Embriología medica con orientación clínica. 8a ed. Buenos Aires: Médica Panamericana, 2001;pp:376-80.

3. Newman TB, Browner WS, Cummings SR, Hulley SB. Designing an observational study: cross-sectional and case-control studies. In: Hulley SB, Cummings SR, Browner WS, editors. Designing clinical research an epidemiologic approach. 2nd ed. Philadelphia: Lippincott Williams & Wilkins, 2001;pp:107-20.

4. Jiménez-Balderas EA, Salamanca-Gómez F, Martínez-Apac S, Bracho-Solís M. Estudio de malformaciones congénitas en 105,825 nacimientos consecutivos. Bol Med Hosp Infant Mex 1985;42:744-7.

5. Cedeño-Rincón R, León A, Romero R. Epidemiología de las malformaciones congénitas externas en una maternidad de Venezuela. Bol Med Hosp Infant Mex 1996;53:117-22.

6. Kankkunen A, Thiringer K. Hearing impairment in connection with preauricular tags. Acta Paediatr Scand 1987;76:143-6.

7. Kugelman A, Tubi A, Bader D, Chemo M, Dabbah H. Preauricular tags and pits in the newborn: the role of renal ultrasonography. J Pediatr 2002;141:388-91.

8. Paulozzi LJ, Lary JM. Laterality patterns in infants with external birth defects. Teratology 1999;60:265-71.

9. Gao JZ, Chen YM, Gao YP. A survey of accessory auricle anomaly. Pedigree analysis of seven cases. Arch Otolaryngol Head Neck Surg 1990;116:194-6.

10. Pinto Escalante D, Castillo Zapata I, Ruiz Allec D, Ceballos Quintal JM. Spectrum of congenital malformations observed in neonates of consanguineous parents. An Pediatr (Barc) 2006;64:5-10.

11. Cleary-Goldman J, Malone FD, Vidaver J, Ball RH, et al. Impact of maternal age on obstetric outcome. Obstet Gynecol 2005;105(5 Pt1):983-90.

12. Wang R, Martínez-Frías ML, Graham JM. Infants of diabetic mothers are increased risk for oculo-auriculo-vertebral sequence: a case-based and case control approach. J Pediatr 2002;141:611-7.

13. Nazer-Herrera J, García-Huidobro M, Cifuentes-Ovalle L. Congenital malformations among offspring of diabetic women. Rev Med Chile 2005;133:547-54.

14. Polanco-Ponce AC, Revilla-Monsalve MC, Palomino-Garibay MA, Islas-Andrade S. Effect of maternal diabetes on human and rat fetal development. Ginecol Obstet Mex 2005;73:544-52.