2008, Number 4
<< Back Next >>
Med Crit 2008; 22 (4)
Thrombotic microangiopathy and intravascular hemolysis (HIMT). A case report
Meneses CJ, González CNP, Gutiérrez MH, Morales GR, Briones GJC
Language: Spanish
References: 21
Page: 248-253
PDF size: 119.65 Kb.
ABSTRACT
We report a case of a 28 years old woman with diagnosis of HIMT associated to preeclampsia with a catastrophic evolution. She had a history of early symptoms since the first prenatal consultation, such as headache, fosfeno and tinnitus, but not intentional follow up was performed. On the 39th week of pregnancy she had increased headache, epigastric pain, unconscious state, severe hypertension, tonic-clonic seizures, respiratory insufficiency that was treated with orotracheal intubation and ventilatory support, gingivorrage and epistaxis, associated to low platelets count, hemolysis, and elevated liver enzymes. She had placental abruption and obitus, a subtotal hysterectomy was performed, and post surgery evolution was complicated with multiple organ failure: renal failure, ARDS, disseminated intravascular coagulation, myocardial depression because of sepsis, hepatic failure, metabolic and gastrointestinal dysfunction. She was released from ICU after 43 days, on stable condition without organic failures. The HIMT is associated to preeclampsia in 4% to 12% of cases; it is important to do an early diagnose a treatment in order to decrease morbidity and mortality and to avoid a catastrophic evolution on the mother and fetus.
REFERENCES
Espinosa MML, Díaz de León PM, Yáñez MI. Microangiopatía trombótica y hemólisis intravascular en la toxemia. Rev Med IMSS (Méx) 1982;20:35-41.
Weinstein L. Syndrome of hemolysis, elevated liver enzymes and low platelet count: a severe consequence of hypertension in pregnancy. Am J Obstet Gynecol 1982;142:159-67.
Sibai BM. The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): much as do about nothing? Am J Obstet Gynecol 1990;162:311-6.
Martin J, Blake P, Perry K et al. The natural history of HELLP syndrome: Patterns of disease progression and regression. Am J Obstet Gynecol 1991;164:1500-13.
Meneses CJ, Figueroa FMR. Síndrome de HELLP. En: Briones-Díaz de León. Preeclampsia-Eclampsia. Dist. y Edit. Mexicana 2000:193-213.
Roberts JM, Taylor RN, Musei TJ. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 1989;161:1200-4.
Ballegeer VC, Sptiz B, De Baene LA. Platelet activation and vascular damage in gestational hypertension. Am J Obstet Gynecol 1992;166:629-33.
Greer IA, Haddad NG, Dawea J. Neutrophil activation in pregnancy-induced hypertension. Br J Obstet Gynecol 1989;96:978-82.
Guntupalli SR, Steingrub J. Hepatic disease and pregnancy: An overview of diagnosis and management. Crit Care Med 2005; 33(10):s332-9.
XXVIII Reunión del Comité Estatal Pro-Vida Materna del Instituto de Salud del estado de México. Unidad de Salud Reproductiva, Metepec, Méx. Mayo 2008.
Sibai BM, Ramadan MK, Usta I, Salama M, Mercer BM, Friedman SA. Maternal morbidity and mortality in 442 pregnancies with hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome). Am J Obstet Gynecol 1993;169:1000-6.
Briones GJC, Díaz de León PM, Barrio PE. Anticuerpo antifosfolípido IgM en preeclampsia-eclampsia. Cir Ciruj 2003;71:449-54.
Sibai BM, Frangieh AY. Management of severe preeclampsia. Curr Opin Obstet Gynecol 1996;8:110-3.
Briones GJC, Gómez Bravo TE, Ávila EF et al. Experiencia TOLUCA en preeclampsia-eclampsia. Cir Ciruj 2005;73:101-5.
O’Hara Padden M. HELLP syndrome: Recognition and perinatal management. Am Fam Physi 1999;63(3):829-39.
Gleeson R, Farrell J, Doyle M, Walshe JJ. HELLP syndrome: a condition of varied presentation. Ir J Med Sc 1996;165:265-7.
Magann EF, Bass D, Chauhan SP, Sullivan DL, Martin RW, Martin JN Jr. Antepartum corticosteroids: disease stabilization in patients with the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP). Am J Obstet Gynecol 1994;171:1148-53.
Magann EF, Perry KG Jr, Meydrech EF, Harris RL, Chauhan SP, Martin JN Jr. Post-partum corticosteroids: accelerated recovery from the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP). Am J Obstet Gynecol 1994;171:1154-8.
Bernard G, Artigas A, Brigham K et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994;149(3):818-24.
Helguera MAM. Síndrome de HELLP. Análisis de 102 casos. Ginec Obstet Méx 1996;64:528-33.
Meneses CJ, Figueroa FMR, Mejía ML et al. Síndrome de HELLP. Presentación de 13 casos y revisión de la literatura. Gac Med Inst Sal Edo. Méx. 1993;3:682-90.