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2008, Number 3

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Rev Mex Anest 2008; 31 (3)

Intravenous total anesthesia in neuroanesthesia: Influence of gender and gender/age on fentanyl consumption

Suárez-Morales M, Mendoza-Popoca CÚ

Language: Spanish
References: 22
Page: 160-165
PDF size: 58.22 Kb.


ABSTRACT

Background: The search for differences of perception of pain and the opioid action over it between both sexes have drawn to multiple and often puzzling results. A great number of papers and efforts are dedicated to bring light over the possible role of sexual steroids on the pain mechanism and on the opioids receptors. In animal investigation a majority of evidence is pointing toward a greater efficacy in males than in females. In human research the results are incongruous. Objective: To investigate if fentanyl anesthetic consumption is different related to sex and if it is age dependent on the neurosurgical patient under total intravenous anesthesia. Method: In 500 neurosurgical patients, divided by age in 3 groups: from 40 or less, 41 through 60 and more than 60 years old, measuring fentanyl consumption and comparing means in the same age group using the Student t test. Results: Fentanyl consumption was always higher in women patients in the 3 groups, although the difference was only statistically significant in the younger group. This sex related difference trends to disappear in elderly patients. Conclusions: Women patients consume more fentanyl than male patients during neurosurgical procedures under total intravenous anesthesia.


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