Palacios BF

Language: Spanish
References: 20
Page: 116-121
PDF size: 74.20 Kb.

ABSTRACT

The use of allograft kept in benzalkonium chloride was first reported in Mexico in 1999 in a study of 70 children reporting an integration rate of 98.5%. This study was undertaken to evaluate functional outcomes of allograft kept in benzalkonium chloride in adult patients, and to examine the histological characteristics of this type of graft, for which there had been no previous study. Methods. With patient consent, surplus reconstructive surgery bone tissue was harvested from 22 adult patients, debrided, and kept in benzalkonium chloride for a period of 6 to 24 months prior to its use in various surgical pathology of patients requiring, void filling or bridging. Bacteriological and histological studies were done on the allograft before their application to the site. A clinical and radiological follow up of patients ensued from May of 2001 to December of 2004. Results. Sixteen allograft patients were evaluated for a period of two years. Twelve (75%) revealed a complete integration of the allograft to the recipient bed site. Four (25%) suffered a disintegration of at least 50% of the initially applied volume. There was no infection, rejection, nor complication related to the procedure in any of the patients. Conclusions. In this series, the integration rate was lower for the adult population than for the pediatric population, as previously reported. This is therefore a clinically acceptable rate. The absence of inherent complications to the allograft is a comforting find that adds to the safety of the procedure. It is a low cost reliable technique that can be easily duplicated.

REFERENCES

1. Garay E, Friedlaender MD: Bone and cartilage transplantation. Clin Orthop 1983; 174: 1.

2. Ollier: Traite des resections 1985, traite de regeneration desos 1867, Osteogenese chirurgica 1991 (citado por Pierre Stagnara).

3. Albee FH: Fundamental in bone transplantation: Experiences in three thousand bone graft operation. JAMA 1923; 81: 1429.

4. Bright RW, Friedlander GE, Sell KW: Current concepts: Tissue banking, the United Status Navy Tissue Bank Milit Med 1977; 142(7): 503-512.

5. Domínguez C: Uso de implantes biológicos de hueso esponjoso sustituto de injerto de hueso autólogo. Rev Mex Ortop Traum 1992; 6(4): 114-118.

6. Friedlander GE: Current concepts review; Bone Banking. J Bone Joint Surg 1982; 64(A): 307-11.

7. Sierra R, Harb E: La experiencia en la integración de aloinjertos conservador en merthiolate. Rev Mex Ortop Trauma 1999; 13(1): 63-64.

8. Trueta J: La estructura del cuerpo humano; injertos óseos. Edit Labor 1974; 27: 221-223.

9. Ahman E, Patzakis M, Roidis N, Shepherd L, Holtom P: Comparison of anterior and posterior iliac crest bone grafts in terms of harvest-site morbidity and functional outcomes. J Bone Joint Surg 2002; 84-A(5):716-720.

10. Finkemeier CF: Bone grafting and bone grafo substitutes. J Bone Joint Surg 2002; 84-A(3): 454-464.

11. Deleu J: Vascularisation of bone grafts in the anterior chamber of the eye. J Bone Joint Surg 1965; 47: 319-329.

12. Enneking WG, Campanacci DA: Retrieved human allografts. J Bone Joint Surg 2002; 84-A(3): 971-986.

13. Inclan A: The use of preserved bone grafs in orthopaedic surgery. J Bone Joint Surg 1942; 24: 81.

14. Andrew LC, Bassett MD: Clinical implication of cell function in bone grafting. Clin Orthop 1972; 87: 49.

15. Erkkis US: Osteoinduction and osteogenesis in implants of allogenic bone matrix. Clin Orthop 1972; 87: 166.

16. Ray RD: Vascularization of bone grafts and implants. Clin Orthop 1972; 87: 43.

17. Turek S: Histología e histopatología del hueso. Ortop Principios y Aplicaciones 1982; 1: 37.

18. Aspectos éticos y legales en banco de hueso. Rev Mex Ortop Traum 1990; 4 Suppl.(1): 20-21.

19. Mankin HJ, Doppelt S, Tompford W: Clinical experience with allograft transplantation, the first ten years. Clin Orthop 1983; 174: 69-86.

20. Velazco ZA, Sierra RL: Banco de hueso en el hospital infantil de la Cd. de México, informe preliminar. Bol Med Hosp Inf 1948: 5.