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ISSN 0188-9796 (Print)

2008, Number 2

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Rev Endocrinol Nutr 2008; 16 (2)

Liver steatosis in obese children

González-Pérez B, Salas-Flores R

Language: Spanish
References: 42
Page: 74-82
PDF size: 134.58 Kb.


ABSTRACT

Since its initial description in the 1980s, pediatric non alcoholic fatty liver disease (NAFLD) has become the most common form of liver disease in children and adolescents. The dramatic rise in obesity observed in recent decades has been accompanied by an increase in the prevalence of obesity related comorbidities, including NAFLD. Clinical findings of the disease included a wide spectrum of liver damage, ranging from simple steatosis to steatohepatitis, variable degrees of fibrosis and cirrhosis. In clinical practice, the diagnosis is usually suspected with elevated chronic levels of serum aminotransferases and presence of ultrasound images of fatty liver (hyperechoic). The gold standard tool to confirm diagnosis of NAFLD is the liver biopsy and is effective as a prognostic indicator, but liver biopsy is invasive and costly. The development of noninvasive surrogate markers and the advancements in imaging technology will aid in the screening of large populations at risk of NAFLD.


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