González-Pérez B, Salas-Flores R

Language: Spanish
References: 29
Page: 59-65
PDF size: 126.62 Kb.

ABSTRACT

Objective: The aim of this study was to evaluate the correlation of ultrasonography liver steatosis with anthropometric measurements, liver enzymes, fasting insulin and glucose, insulin resistance/sensitivity, lipid profile, and to evaluate the role of pubertal stage. Material and methods: The study was observational, analytic cross-sectional, and opened, in obese children and adolescent, aged 2 to 18 years. There were included 46 obese patients that were divided by presence of liver steatosis in two groups. The waist-hip ratio, body mass index (BMI), blood pressure, and penis index volume (PIV) was assessed and physical examination was performed to evaluate pubertal stage and the presence of acanthosis nigricans. Serum levels of fasting glucose, insulin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP) and lipid profile were performed as well as glucose and insulin 2 hours after an oral glucose load. To determine the insulin resistance/sensitivity was used the homeostasis model assessment (HOMA) and quantitative insulin sensitivity check index (QUICKI), respectively. Results: The prevalence of ultrasonography liver steatosis was found in 28.3% of patients and was more frequent in pubertal stage I. The levels of BMI, waist circumference, fasting insulin, glucose of 2 hours, TC, LDL-C, ALT, AST and GGT of group 1 (with steatosis) were significantly higher than of group 2 (without steatosis). The mean value of HOMA was significantly higher in group 1 compared with group 2. Conclusions: Liver ultrasonogram should be a part of the early evaluation of obese children. Although children with liver steatosis had more severe obesity.

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