Campos MC, Cuadra ZTE, Rodríguez EG, Fernández FJ

Language: English
References: 61
Page: 88-98
PDF size: 227.70 Kb.

ABSTRACT

Antibiosis history began with the observations made by Sanderson and Roberts on the inhibition of bacterial growth by other organisms, at the end of the XIX Century. Biomedical research in this field advanced importantly during World War II, after the discovery of penicillin by Fleming. Brotzu´s finding of cephalosporin and the massive production of these two compounds started a new era, not only for important breakthroughs in treating diseases, but also for the exploitation of living organisms to produce substances of great benefit for mankind (known today as biotechnology). In this review, we summarize the historic evolution of the knowledge about penicillin and cephalosporin, from the first observations on producer microorganisms and the chemistry of these antibiotics up to the modern ways of genetic engineering focused on developing superproducer strains at an industrial level.

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