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ISSN 0185-3252 (Print)
Revista de la Asociación Médica del Centro Médico ABC

2008, Number 1

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An Med Asoc Med Hosp ABC 2008; 53 (1)

Peduculated cellular angiofibroma of the labia majora. Clinicopathologic and immunohistochemical study of an unusual soft tissue tumor characteristic of the perineal region

Jorge-Buys DL, Ortiz-Sánchez E, Padilla-Rodríguez Á, Ortiz-Hidalgo C

Language: Spanish
References: 19
Page: 36-40
PDF size: 225.18 Kb.


ABSTRACT

Cellular angiofibroma (CAF) is a recently characterized histologically distinctive benign mesenchymal neoplasm originally described by Nuci et al in 1997. CAF has a predilection for the vulval region, and comprised by two principal components; cellular spindle cell and prominent stromal blood vessels. Characteristically CAF are small tumors (‹ 3 cm) that are generally well circumscribed, typically arising in middle-aged patients (average age 47). By immunohistochemistry these cases are positive for vimentin and CD34 (60 %) but negative for actin and desmin, which is important in excluding many of the other vulvovaginal mesenchymal lesions which enter into the differential diagnosis, such as angiomyxoma and angiomyofibroblastoma. CAFs are almost always positive for estrogen and progesterone receptors, suggesting that they probably arise from the hormone receptor-positive subepithelial mesenchymal layer from the lower female genital tract. We present herein a case of cellular angiofibroma, in a 40 year-old woman that presented clinically as a Bartholin’s glandular cyst. CAFs belong to the group of fibrous spindle cell lesions that affect the vulva.


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