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Instituto Nacional de Salud Pública

2004, Number 1

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salud publica mex 2004; 46 (1)

Plasmodium vivax and Plasmodium falciparum gametocyte

Contreras-Ochoa C, Ramsey JM

Language: Spanish
References: 61
Page: 64-70
PDF size: 115.43 Kb.


ABSTRACT

Plasmodium gametocytes are responsible for transmission from the vertebrate host to the mosquito. Plasmodium game­tocytes undergo a complex cycle from asexual stages, through a poorly understood process characterized by ex­pression of stage-specific proteins and adhesion molecules. Gametocytes are capable of inducing specific humoral IgG, and cellular responses, which include induction of TNFα, IFNγ and γδ+ lymphocyte proliferation, in addition to im­mune responses to other stages of the parasite (sporozoite, exo-erythrocytic stages, erythrocytic stages).Although trans­mission-blocking vaccines against Plasmodium do not cur­rently include components against the gametocytes (rather they focus on gametes, zygotes or ookinetes, stages which occur in the mosquito), further understanding of the mech­anisms underlying garnetocytogenesis and immune responses against these stages may provide additional strategies for more effective transmission inhibition.


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