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Instituto Nacional de Salud Pública

2004, Número 1

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salud publica mex 2004; 46 (1)


Gametocitos de Plasmodium vivax y Plasmodium falciparum: etapas relegadas en el desarrollo de vacunas

Contreras-Ochoa C, Ramsey JM

Idioma: Español
Referencias bibliográficas: 61
Paginas: 64-70
Archivo PDF: 115.43 Kb.


RESUMEN

Los gametocitos de Plasmodium son los responsables de la transmisión del huésped vertebrado al mosquito vector. Sufren un proceso de desarrollo complejo a partir de parásitos asexuales, que no está completamente entendido, expresando proteínas y moléculas de adhesión especificas. Son capaces de inducir una respuesta inmune humoral específica con anticuerpos IgG, y celular específica, con producción de TNFα, IFNγ y proliferación de linfocitos γδ+, aun cuando existen respuestas inducidas en contra de las etapas previas del parásito (esporozoito, exo-eritrocítica y eritrocítica). Las vacunas destinadas a bloquear la transmisión del parásito no contemplan a los gametocitos circulantes en el huésped como blancos de acción, sino que van en­focadas contra antígenos expresados en los gametos y en las etapas posfertilización. El estudio de los mecanismos que regulan la producción de gametocitos y de la respuesta inmune contra éstos, ofrece una oportunidad para el desa­rrollo de estrategias adicionales para el control de la trans­misión.


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