2007, Number S4
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Arch Cardiol Mex 2007; 77 (S4)
Genetic polymorphisms in cardiovascular diseases. The experience in the National Institute of Cardiology “Ignacio Chávez”
Vargas AG
Language: Spanish
References: 33
Page: 88-93
PDF size: 104.73 Kb.
ABSTRACT
The knowledge of the complete human genome sequence and the application of new molecular techniques is providing important information about the genetic markers associated with the development of several diseases. Cardiovascular diseases are of special interest for these studies since they are an important worldwide health problem. These diseases have a multifactorial etiology, therefore, many genetic and environmental factors participate to generate them. The identification of susceptibility genes has the potential to aid in the development of new treatments and to enhance the prediction of disease risk. Thus, the strategy has been to analyze polymorphisms presents in candidate genes coding for important proteins in the homeostatic system involved in maintaining cardiovascular health. Several studies have been reported in caucasian, asian and african populations, however, few data are available in the mexican population. The revision discusses recently published data of polymorphic markers associated with cardiovascular disease in the Mexican population.
REFERENCES
Lisker R, Perez-Briceno R, Granados J, Babinsky V, de Rubens J, Armendares S, et al: Gene frequencies and admixture estimates in a Mexican City population. Am J Physical Anthropol 1986; 71: 203-207.
Lisker R, Pérez-Briceño R, Granados J, Babinsky V: Gene frequencies and admixture estimates in the State of Puebla, Mexico. Am J Physical Anthropol 1988; 76: 331-335.
Lisker R, Ramirez E, Pérez-Briceño R, Granados J, Babinsky V: Gene frequencies and admixture estimates in four Mexican Urban Centers. Hum Biology 1990; 62: 791-801.
Vargas-Alarcon G, Hernandez-Pacheco G, Moscoso J, Perez-Hernandez N, Murguia LE, Moreno A, et al: HLA genes in Mexican Teeneks: HLA genetic relationship with other worldwide populations. Mol Immunol 2006; 43: 790-799.
Vargas-Alarcon G, Moscoso J, Martinez-Laso J, Rodriguez-Perez JM, Flores-Dominguez C, Serrano-Vela JI, et al: Origin of Mexican Nahuas (Aztecs) according to HLA genes and their relationships with worldwide populations. Mol Immunol 2007; 44: 747-755.
Vargas-Alarcon G, Hernandez-Pacheco G, Rodriguez-Perez JM, Perez-Hernandez N, Pavon Z, Fragoso JM, et al: Angiotensin-converting enzyme gene (ACE) insertion/deletion polymorphism in Mexican populations. Hum Biol 2003; 75: 889-896.
Gamboa R, Zamora J, Rodriguez-Perez JM, Fragoso JM, Cardoso G, Posadas-Romero C, Vargas-Alarcon G: Distribution of paraoxonase PON1 gene polymorphisms in Mexican populations. Its role in the lipid profile. Exp Mol Pathol 2006; 80: 85-90.
Fragoso JM, Rodriguez-Perez JM, Perez-Vielma N, Martinez-Rodriguez N, Vargas-Alarcon G: Beta1 adrenergic receptor polymorphisms Arg389Gly and Ser49Gly in the Amerindian and Mestizo populations of Mexico. Hum Biol 2005; 77: 515-520.
Yue1 P, Melamud E, Moult J: SNPs3D: Candidate gene and SNP selection for association studies. BMC Bioinformatics 2006; 7: 166-174.
Casas JP, Cooper J, Miller GJ, Hingorani AD, Humphries SE: Investigating the Genetic Determinants of Cardiovascular Disease Using Candidate Genes and Meta-analysis of Association Studies. Ann Hum Genet 2006; 70: 145-169.
Berg K: Genetics of coronary heart disease and its risk factors. CIBA Foundation Symposium 1987; 130: 14-133.
Keavney B: Genetic epidemiological studies of coronary heart disease. Int J Epidemiol 2002; 31: 730-736.
Libby P: Vascular biology of atherosclerosis: overview and state of the art. Am J Cardiol 2003; 91(3A): 3A-6A.
Rader DJ, Maugeais C: Genes influencing HDL metabolism: new perspectives and implications for atherosclerosis prevention. Mol Med Today 2000; 6: 170-175.
Yamada Y: Identification of genetic factors and development of genetic risk diagnosis systems for cardiovascular diseases and stroke. Circ J 2006; 70: 1240-1248.
Mattu RK, Needham EW, Galton DJ, Frangos E, Clark AJ, Caulfield M: A DNA variant at the angiotensin-converting enzyme gene locus associates with coronary artery disease in the Caerphilly heart study. Circulation 1995; 91: 270-274.
Nakai K, Itoh C, Miura Y, Hotta K, Musha T, Itho T, et al: Deletion polymorphism of the angiotensin I- converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese. Circulation 1994; 90: 2199-2202.
Cambien F, Poirier O, Lecerf L, Evans A, Cambou JP, Arveiler D, et al: Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 1992; 359: 641-644.
Vargas-Alarcon G, Zamora J, Sanchez-Garcia S, Rodriguez-Perez JM, Cardoso G, Posadas-Romero C: Angiotensin-I-converting enzyme (ACE) insertion/deletion polymorphism in Mexican patients with coronary artery disease. Association with the disease but not with lipid levels. Exp Mol Pathol 2006; 81: 131-135.
Iwai C, Akita H, Shiga N, Takai E, Miyamoto Y, Shimizu M, et al: Suppressive effect of the Gly389 allele of the beta1-adrenergic receptor gene on the occurrence of ventricular tachycardia in dilated cardiomyopathy. Circ J 2002; 66: 723-728.
Feldman MD: Adrenergic receptor polymorphism and cardiac function (and dysfunction). Circulation 2001; 103: 1042-1043.
Fragoso JM, Rodriguez-Perez JM, Perez-Vielma N, Martinez-Rodriguez N, Vargas-Alarcon G: Beta1 adrenergic receptor polymorphisms Arg389Gly and Ser49Gly in the Amerindian and Mestizo populations of Mexico. Hum Biol 2005; 77: 515-520.
Fragoso JM, Rodriguez-Perez JM, Gonzalez J, Cruz D, Perez-Mendez O, de Jesus Garcia J, et al: Beta1-adrenergic receptor gene polymorphisms in Mexican patients with idiopathic dilated cardiomyopathy. Exp Mol Pathol 2006; 80: 279-282.
Cunha-Neto E, Kalil J: Heart-infiltrating and peripheral T cells in the pathogenesis of human Chagas’ disease cardiomyopathy. Autoimmunity 2001; 34: 187-192.
Kierszenbaum F: Views on the autoimmunity hypothesis for Chagas’ disease pathogenesis. FEMS Immunol Med Microbiol 2003; 37: 1-11.
Beraun Y, Nieto A, Collado MD, Gonzalez A, Martin J: Polymorphysms at tumor necrosis factor (TNF) loci are not associated with Chagas’disease. Tissue Antigens 1998; 52: 81-83.
Colorado IA, Acquatella H, Catalioti F, Fernandez MT, Layrisse Z: HLA class II DRB1, DQB1, DPB1 polymorphism and cardiomyopathy due to Trypanosoma cruzi chronic infection. Hum Immunol 2000; 61: 320-325.
Cruz-Robles D, Reyes PA, Monteon-Padilla VM, Ortiz-Muniz AR, Vargas-Alarcon G: MHC class I and class II genes in Mexican patients with Chagas disease. Hum Immunol 2004; 65: 60-65.
Rodriguez-Perez JM, Cruz-Robles D, Hernandez-Pacheco G, Perez-Hernandez N, Murguia LE, Granados J, et al: Tumor necrosis factor-alpha promoter polymorphism in Mexican patients with Chagas’ disease. Immunol Lett 2005; 98: 97-102.
Amigo MC, Martínez-Lavín M, Reyes PA: Acute rheumatic fever. Rheum Dis Clin North Am 1993; 19: 333-350.
Miller LC, Gray ED, Mansour M, Abdin ZH, Kamel R, Zaher S, et al: Cytokines and immunoglobulin in rheumatic heart disease: production by blood and tonsillar mononuclear cells. J Rheumatol 1989; 16: 1436-1442.
Hernandez-Pacheco G, Aguilar-Garcia J, Flores-Dominguez C, Rodriguez-Perez JM, Perez-Hernandez N, Alvarez-Leon E, et al: MHC class II alleles in Mexican patients with rheumatic heart disease. Int J Cardiol 2003; 92: 49-54.
Hernandez-Pacheco G, Flores-Dominguez C, Rodriguez-Perez JM, Perez-Hernandez N, Fragoso JM, Saul A, et al: Tumor necrosis factor-alpha promoter polymorphisms in Mexican patients with rheumatic heart disease. J Autoimmun 2003; 21: 59-63.