Vargas AG

Idioma: Español
Referencias bibliográficas: 33
Paginas: 88-93
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RESUMEN

El conocimiento de la secuencia completa del genoma humano y la aplicación de nuevas técnicas moleculares ha generado importante información acerca de los marcadores genéticos asociados con el desarrollo de enfermedad. Las enfermedades cardiovasculares han tenido especial interés en estos estudios dada su importancia como problema de salud a nivel mundial. Las enfermedades cardiovasculares tienen una etiología multifactorial con participación de factores genéticos y ambientales, por lo que la identificación de genes de susceptibilidad tiene relevancia para el desarrollo de nuevos tratamientos y la predicción del riesgo de enfermedad. Así, la estrategia ha sido analizar los polimorfismos presentes en genes candidatos que codifican para proteínas importantes en el sistema homeostático encargado de mantener el buen funcionamiento del sistema cardiovascular. Se han reportado varios estudios en poblaciones caucásicas, asiáticas y africanas pero hay pocos datos en la población mexicana. En la presente revisión se discuten algunos de los datos publicados de marcadores polimórficos asociados con enfermedades cardiovasculares en la población mexicana.

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