Martínez-Salgado H, Casanueva E, Rivera-Dommarco J, Viteri FE, Bourges-Rodríguez H

Language: Spanish
References: 35
Page: 86-99
PDF size: 198.83 Kb.

ABSTRACT

Iron deficiency is the most common nutritional deficiency worldwide. In Mexico, in 2006, 37.8% of children under 2 years of age were diagnosed as anemic. Similarly, 20% of children between 2-5 years of age, as well as 16.6% of children between 5-11 years of age were diagnosed with anemia. Children 1-4 years of age consuming a Mexican diet ingest an adequate amount of iron (» 6.2 mg/day), but the intake of heme-iron is low, and ingestion of iron absorption inhibitors is high; thus, the overall iron bioavailability in the diet is poor (3.85%). Strategies to prevent and treat iron deficiency and anemia may be focused on either increasing the amount of ingested iron or lowering iron losses; whereas in the newborn, delayed umbilical cord clamping is advised. These strategies require a comprehensive and concerted aproach among institutions, governmental sectors, community active members, educators, risk groups, families, etc.

REFERENCES

1. Posey J, Gherardini F. Lack of a role for iron in the Lyme disease pathogen. Science. 2000; 288: 1651-3.

2. Heinrich H, Bartels H, Goetze C, Schafer KH. Normal range of intestinal iron absorption in newborns and infants. Klinica Wochenschriver. 1969; 47: 984-91.

3. Latunde-Dada G, Van der Westhuizen J, Vulpe C, Anderson GJ, Simpson RJ, McKie AT. Molecular and functional roles of duodenal cytochrome b (dcytb) in iron metabolism. Blood Cell Molec Dis. 2002; 29: 356-60.

4. Rosado J, Bourges H, Saint-Martin B. Deficiencia de vitaminas y minerales en México. Una revisión crítica del estado de la información: deficiencia de minerales. Salud Publica Mex. 1995; 37: 130-9.

5. Oláiz G, Rivera J, Shamah T, Rojas R, Villalpando S, Hernández M, et al. Encuesta Nacional de Salud y Nutrición 2006. Cuernavaca, México: Instituto Nacional de Salud Pública; 2006.

6. Rivera J, Sotrés-Álvarez D, Habicht JP, Shamah T, Villalpando S. Impact of the Mexican Program for Education, Health and Nutrition (Progresa) on rates of growth and anemia in infants and young children. A randomized effectiveness study. JAMA. 2004; 291: 2563-70.

7. Villalpando S, García-Guerra A, Ramírez-Silva C, Mejía-Rodríguez F, Matute-Chem G, Shamah Levy T, et al. l. Iron, zinc and iodide status in Mexican children under 12 years and women 12-49 years of age. A probabilistic national survey. Salud Publica Mex. 2003; 45: S520-S9.

8. Villalpando S, Shamah-Levy T, Ramírez-Silva C, Mejía-Rodríguez F, Rivera-Dommarco J. Prevalence of anemia in children 1 to 12 years of age. Results from a nationwide probabilistic survey in Mexico. Salud Publica Mex. 2003; 45(Supl 4): S490-S8.

9. Rivera-Dommarco J, Shamah-Levy T, Villalpando-Hernández S, González-de Cossío T, Hernández-Prado B, Sepúlveda J. Encuesta Nacional de Nutrición 1999. Estado nutricio de niños y mujeres en México. Cuernavaca, Morelos, México: Instituto Nacional de Salud Pública; 2001.

10. Duque-López M, Flores-Hernández S, García-Morales R, Mendoza ME, Méndez I, Flores-Huerta S, et al. Prevalencia de anemia, de deficiencia de hierro, ácido fólico y cinc, en menores de 2 años, usuarios de los servicios de salud del Instituto Mexicano del Seguro Social. En: Flores-Huerta S, Martínez-Salgado H, editores. Prácticas de alimentación, estado de nutrición y cuidados a la salud en niños menores de 2 años en México. México: Instituto Mexicano del Seguro Social; 2004.

11. Bothwell T, Charlton R, Cook J, Finch C. Iron metabolism in man. Oxford: University Press; 1979.

12. Horton S, Ross J. The economics of iron deficiency. Food Policy. 2003; 28: 51-75.

13. Khan K, Wojdyla D, Say I, Gulmezoglu AM, Van Look PF. WHO analysis of causes of maternal death: a systematic review. Lancet. 2006; 367: 1066-74.

14. Lozoff B, Kacirotti N, Walter T. Iron deficiency in infancy: applying a physiologic framework for prediction. Am J Clin Nutr. 2006; 84: 1412-21.

15. Beard J, Connor J. Iron status and neural functioning. Annu Rev Nutr. 2003; 23: 41-58.

16. Andersen H, Gambling L, Holtrop G, McArdle HJ. Maternal iron deficiency identifies critical windows for growth and cardiovascular development in the rat post implantation embryo. J Nutr. 2006; 136: 1171-7.

17. Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr. 2001; 131: S649-S68.

18. Sachdev H, Gera T, Nestel P. Effect of iron supplementation on mental and motor development in children: A systematic review of randomized controlled trials. Pub Health Nutr. 2005; 8: 117-32.

19. De Silva A, Atukorala S, Weerasinghe I, Ahluwalia N. Iron supplementation improves iron status and reduces morbidity in children with or without upper respiratory tract infection: a randomized controlled study in Colombo, Sri Lanka. Am J Clin Nutr. 2003; 77: 234-41.

20. Leong WI, Lönnerdal B. Hepcidin, the recently identified peptide that appears to regulate iron absorption. J Nutr. 2004; 134: 1-4.

21. Nemeth E, Tuttle M, Powelson J, Vaughn MB, Donovan AQ, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004; 306: 2090-3.

22. Frazer D, Wilkins S, Becker E, Vulpe CD, McKie AT, Trinder D, et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology. 2002; 123: 835-44.

23. WHO. Iron Deficiency Anemia. Assessment, Prevention and Control. A Guide for Programme Managers. Geneva: World Health Organization; 2001.

24. Rodríguez S, Hotz C, Rivera J. Bioavailable dietary Iron is associated with hemoglobin concentration in Mexican preschool children. J Nutr. 2007; 137: 2304-10.

25. Chaparro C, Neufeld L, Tena-Álvarez G, Aguía-Liz R, Dewey K. Effect of timing of umbilical cord clamping on iron status in Mexican infants: a randomized controlled trial. Lancet. 2006; 367: 1997-2004.

26. Beaton GH, McCabe G. Efficacy of intermittent iron supplementation in the control of iron deficiency anaemia in developing countries: An analysis of experience-final report to the micronutrient initiative. Montreal: Micronutrient Initiative; 1999.

27. World Health Organization. Report of the Word Health Organization Technical Consultation on Prevention and Control of Iron Deficiency in Infants and young Children in Malaria-Endemic Areas. Food Nutr Bull. 2006; 28: S489-S627.

28. Andang’o P, Osendarp S, Ayah R, West CE, Mwaniki DL, de Wolf CA, et al. Efficacy of iron-fortified whole maize flour on iron status of schoolchildren in Kenya: a randomized controlled trial. Lancet. 2007; 369: 1799-806.

29. Villalpando S, Shamah T, Rivera J, et al. Fortifying milk with ferrous gluconate and zinc oxide in a public nutrition program reduced the prevalence of anemia in toddlers. J Nutr. 2006; 136: 2633-7.

30. Rivera J, Shamah T, Villalpando S, Lara Y, Monterrubio E. Effectiveness of an iron fortified milk distribution program on iron status and anemia in infants and young children in Mexico. San Francisco, CA: Experimental Biology; 2006. p. 375-6.

31. Stoltzfus RJ, Dreyfuss M. Guidelines for the use of iron supplements to prevent and treat iron deficiency anemia. Washington DC: International Nutritional Anemia Consultative Group, World Health Organization and UNICEF, International Life Sciences Institute; 1998.

32. Stoltzfus R, Mullany L, Black R. Iron deficiency anemia. En: Ezzati MLA, Rodgers A, Murray C, editores. Comparative quantification of health risks: Global and regional burden of disease attributable to selected major risk factors. Geneva: World Health Organization; 2004. p. 163–209.

33. McCann J, Ames B. An overview of evidence for a causal relation between iron deficiency during development and deficit in cognitive or behavioral function. Am J Clin Nutr. 2007; 85: 931-45.

34. Zimmermann M, Hurrel R. Nutritional iron deficiency. Lancet. 2007; 370: 511- 20.

35. Beard J, Zhan C, Brigham D. Growth in iron-deficient rats. Proc Soc Exp Biol Med. 1995; 209: 65-72.