Martínez-Quiroz ZI, Lugo-Goytia G, Esquivel-Rodríguez VM

Language: Spanish
References: 14
Page: 220-224
PDF size: 102.32 Kb.

ABSTRACT

Objective: To compare the efficacy and safety of the combination propofol/ketamine versus propofol/fentanyl in patients undergoing ambulatory colonoscopy. The study tested the hypothesis that analgesia/sedation with propofol /ketamine (P-K) would be more effective when compared with propofol/fentanyl (P-F) for ambulatory colonoscopy. Methods: A randomized, double-blinded clinical trial was conducted with 50 ambulatory adult patients that were allocated to receiving either conscious analgesia/sedation with P-K or P-F. The cardiorespiratory parameters and bispectral index were monitored and recorded. The quality of the analgesia was assessed with a Numerical Pain Rating Scale; recovery level and return of psychomotor efficiency were evaluated with the Aldrete scale and the Post Anesthesia Discharge Scoring system, respectively. Results: Both groups of 25 patients were comparable with respect to demographic data, initial parameters, and duration of colonoscopy. All patients in the P-K group mentioned that the colonoscopy was painless. In the P-F group, the average pain intensity score was 0.8 (p ‹ 0.05). There were not statistically significant differences between the P-K and P-F groups regarding the recovery time. In the P-F group, the haemodynamic changes and signs of respiratory depression were significant (p ‹ 0.05). Conclusions: Combined administration of propofol and ketamine for colonoscopy provided sufficient analgesia, satisfactory haemodynamic stability, minor respiratory depression, and rapid recovery. It allowed patients to be discharged approximately 25 minutes after the procedure.

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