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Academia Mexicana de Neurología, A.C.

2006, Number 5

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Rev Mex Neuroci 2006; 7 (5)

Spinocerebellar ataxia type 2. Hypoglosal nerve conduction studies

Medrano MJ, Velásquez PL, Canales ON

Language: Spanish
References: 34
Page: 380-384
PDF size: 81.73 Kb.


ABSTRACT

Introduction: Spinocerebellar Ataxia type 2 have de highest prevalence in the world in Holguín (Cuba). Is caused by a CAG repeated expansions in SCA2 gene and distinguished for cerebellar syndrome with depressed tendon reflexes, poor coordination of sacadic eye movements, speech and deglution. The aim of these study is to determine functional state of hypoglosal nerve in SCA2 patients using motor nerve conduction studies. Patients and methods: First we determine the CAG repeat expansion in 43 SCA2 illnes patients, them made electrophysiological studies (motor nerve conduction studies) in these patients and in 100 healthy subjects used as control group. Results: There were latency and duration prolongation of the motor potential in illnes patients respect control group (p = 0.001 y 0.011, respectively) that evidence a myelinic damage in XII par fibers in SCA2 patients.


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