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ISSN 0188-9796 (Print)

2007, Number 3

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Rev Endocrinol Nutr 2007; 15 (3)

Insulinotropic polypeptide dependent of glucose and peptide similar to glucagons type 1: physiological actions and implications in obesity and type 2 diabetes

Romero ZA

Language: Spanish
References: 63
Page: 156-164
PDF size: 129.28 Kb.


ABSTRACT

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulin releasing polypeptide (GIP) are the main hormones responsible for incretin effect. Therefore, the more relevant physiological effect of both hormones is glucose homeostasis regulation after meal ingestion mediated through stimulation of insulin secretion and diverse extrapancreatic actions. In experimental models they have shown proliferation of β cells, cardioprotective effects, fat metabolism regulation in adipocytes and promotion of bone formation. Subjects with type 2 diabetes display a slight decrease of GLP-1 secretion and insulinotropic activity defect of GIP. GIP participates in the pathogenesis of obesity and insulin resistance induced by diets with high fat content in certain types of mice.


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