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Instituto Nacional de Neurología y Neurocirugía

2006, Number 2

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Arch Neurocien 2006; 11 (2)

Parkinson’s disease: molecular aspects and prospective neuroprotective and restorative therapies

Hernández-Montiel HL

Language: English
References: 121
Page: 100-111
PDF size: 1613.76 Kb.


ABSTRACT

Parkinson´s disease (PD) is the most common neurodegenerative movement disorder and is characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta. The main obstacle to developing neuroprotective and restorative therapies is a limited understanding of the key molecular events that provoke neurodegeneration. In order to establish causal or protective treatments for PD, it is necessary to identify the cascade of deleterious events that lead to the dysfunction and death of dopaminergic neurons. This review summarizes most recent insights gained from many studies in this disorder.


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