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Instituto Nacional de Neurología y Neurocirugía

2006, Número 2

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Arch Neurocien 2006; 11 (2)


Enfermedad de parkinson: aspectos moleculares terapia restaurativa y neuroprotección

Hernández-Montiel HL

Idioma: Ingles.
Referencias bibliográficas: 121
Paginas: 100-111
Archivo PDF: 1613.76 Kb.


RESUMEN

La enfermedad de Parkinson (EP) es el trastorno neurodegenerativo del movimiento más común y está caracterizado por la pérdida progresiva de las neuronas dopaminérgicas en la sustancia negra, pars compacta. El principal obstáculo para el desarrollo de terapias de neuroprotección y restauración es el conocimiento limitado de los eventos moleculares que provocan esta neurodegeneración. Para poder desarrollar terapias que prevengan o protejan de EP, es necesario identificar la cascada de eventos deletéreos que provocan la disfunción y muerte de las neuronas dopaminérgicas. Esta revisión resume los últimos hallazgos en el estudio de esta enfermedad.


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