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Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio

2007, Number 4

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Rev Mex Patol Clin Med Lab 2007; 54 (4)

Invasive squamous carcinoma of the uterine cervix. An study on the expression of P53, BCL-2, KI-67, C-MYC, and cyclin D1

Alameda F, Baro T, Mariñoso ML, Manresa JM, Costa C, Espinet B, Fuste P, Mancebo G, Carreras R, Sole F, Serrano S

Language: Spanish
References: 39
Page: 150-158
PDF size: 223.85 Kb.


ABSTRACT

A descriptive study of p53, BCL-2, Ki-67, C-MYC and cyclin D1 immunohistochemical expression in 40 cervical squamous cell carcinoma using tissue arrays, was carried out. The data obtained were related with some clinical and morphological parameters as tumor size, vessel, uterine body and parametrial invasion, and lymph node metastases. The results show only relation between cyclin D1 expression and uterine body invasion. Then, the relationship between C-MYC and Ki-67 expression, between C-MYC and cyclin D1 expression, and between cyclin D1 and Ki-67LI, was observed. These results are discussed.


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