medigraphic.com
ISSN 0185-6014 (Impreso)
Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio

2007, Número 4

<< Anterior Siguiente >>

Rev Mex Patol Clin Med Lab 2007; 54 (4)


Carcinoma escamoso invasor de cérvix uterino. Estudio de la expresión de p53, BCL-2, Ki-67, C-MYC y ciclina D1

Alameda F, Baro T, Mariñoso ML, Manresa JM, Costa C, Espinet B, Fuste P, Mancebo G, Carreras R, Sole F, Serrano S

Idioma: Español
Referencias bibliográficas: 39
Paginas: 150-158
Archivo PDF: 223.85 Kb.


RESUMEN

Se realiza un estudio descriptivo de la expresión inmunohistoquímica de p53, BCL-2 Ki-67, C-MYC, y ciclina D1 en 40 casos de carcinoma escamoso infiltrante en relación a parámetros morfológicos como: tamaño, estadio, invasión vascular, invasión de cuerpo uterino, invasión de parametrios y metástasis ganglionares utilizando array de tejidos. Solamente se encuentra relación entre la expresión de ciclina D1 y la invasión de cuerpo uterino, de forma estadísticamente significativa. Se observa además relación entre la expresión de C-MYC y Ki-67LI, C-MYC y ciclina D1, y ciclina D1 y Ki-67LI.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Akasofi M, Oda Y. Immunohistochemical detection of p53 in cervical epithelial lesions with or without infection of HPV 16 and 18. Wirchows Arc 1995; 425 (6): 593-602.

  2. Mittal KR, Lin O, Chan W, Goswami S, Demopoulos RI. Cervical squamous cell dysplasias and carcinomas with immunodetectable p53 frequently contain HPV. Gynecol Oncol 1995; 58 (3): 289-294.

  3. Chen CA, Chen TM, Wu CC, Chang CF, Hsieh CY. Human Papillomavirus DNA and p53 in stage iB bulky cervical cancer. J Cancer Res Clin Oncol 1994; 120 (11): 678-682.

  4. Hachisuga T, Matsuo N, Iwasaka T, Sugimori H, Tsuneyoshi M. HPV and p53 overexpression in carcinomas of the uterine cervix, lower uterine segment and endometrium. Pathology 1996; 28 (1): 28-31.

  5. Uchiyama M, Iwasaka T, Matsuo N, Hachisuga T, Mori M et al. Correlation between HPV and p53 gene overexpression in adenocarcinoma of the uterine cervix. Gynecol Oncol 1997; 65 (1): 23-29.

  6. Bar JK, Markowska J, Harloziska A, Sedlackzek P, Nowak M et al. Relation between infection with HPV and expression of p21 and p53 oncoproteins in patients with cancer of the uterine cervix. Eur J Gynaecol Oncol 1996; 17 (4): 283-285.

  7. Busby-Earle RM, Steel CM, Williams AR, Cohen B, Bird CC. P53 mutations in cervical carcinogenesis-low frequency and lack of correlation with human papillomavirus status. Br J Cancer 1994; 69 (4): 732-737.

  8. Herrington CS, Woraham M, Southern SA, Mackowiak P, Wolman SR. Loss of sequences on the short arm of chromosome 17 is a late event in squamous cell carcinoma of the cervix. Mol Pathol 2001; 54 (3): 160-164.

  9. Ngan HY, Tsao SW, Liu SS, Stanley M. Abnormal expression and mutation of p53 in cervical cancer. A study at protein RNA and DNA levels. Genitourin Med 1997; 73 (1): 54-58.

  10. Dellas A, Schultheiss E, Almendral AC, Gudat E, Oberholzer M et al. Altered expression of mdm-2 and its association with p53 protein status tumor cell proliferation rate and prognosis in cervical neoplasia. Int J Cancer 1997; 74 (4): 421-425.

  11. Suo Z, Holm R, Nesland JM. Squamous cell carcinomas, an immunohistochemical and ultrastructural study. Anticancer Res 1992; 12 (68): 2025-2031.

  12. Tang ZH, Cai QF, Ye XA. Expression of bck-2, cerbB2 and p53 protein in cervical epithelial carcinogenesis. Ai Zheng 2003; 22 (10): 1057-1061.

  13. Horn LC, Fischer U, Hanel C, Kuhn H, Raptis G et al. P53 in surgically treated and pathologically staged cervical cancer: correlation with local tumor progression, but not with lymphatic spread. Pathol Res Pract 2001; 197 (9): 605-609.

  14. Graflund M, Sorbe B, Karlson M. Immunohistochemical expression of p53, BCL-2 and p21 (WAF1/C1P1), in early cervical carcinoma: correlation with clinical outcome. Int J Gynecol Cancer 2002; 12 (3): 290-298.

  15. Avall-Lundqvist EH, Silfversward C, Aspenblad U, Nilsson BR, Auer GU. The impact of tumor angiogenesis, p53 overexpression and proliferative activity (MIB-1) on survival squamous cervical carcinoma. Eur J Cancer 1997; 33 (11): 1799-1804.

  16. Ebara T, Mitsuhashi N, Saito Y, Sakurai H, Hasegawa M et al. Prognostic significance of immunohistochemically detected p53 protein expression in stage IIIB squamous cell carcinoma of the uterine cervix treated with radiation therapy alone. Gynecol Oncol 1996; 63 (2): 216-218.

  17. Hunt CR, Hale RJ, Buckley CH, Hunt J. P53 expression in carcinoma of the cervix. J Clin Pathol 1996; 49 (12): 971-974.

  18. Chen HY, Hsu CT, Lin WC, Tsai HO, Chang WC. Prognostic value of p53 expression in stage IB1 cervical carcinoma. Gynecol Obstet Invest 2000; 49 (4): 266-271.

  19. Oka K, Suzuki Y, Nakano T. Expression of p27 and p53 in cervical squamous cell carcinoma patients treated with radiotherapy alone: radiotherapeutic effect and prognosis. Cancer 2000; 88 (12): 2766-2773.

  20. Cavuslu S, Goodlad J, Hobbs C, Connor AM, Raju KS et al. Relationship between human papillomavirus infection and overexpression pf p53 protein in cervical carcinomas and lymph node metastases. J Med Virol 1997; 53 (2): 111-117.

  21. Saito J, Hoshiai H, Noda K. Type of HPV and expression of p53 in elderly women with cervical cancer. Gynecol Obstet Invest 2000; 49 (3): 190-193.

  22. Dobbs SP, Hewett PW, Johnson IR, Carmichael J, Murray JC. Angiogenesis is associated with vascular endothelial growth factor expression in cervical intraepithelial neoplasia. Br J Cancer 1997; 76 (11): 1410-1415.

  23. Grace VM, Shalini JV, Lekha TT, Devaraj SN, Devaraj H. Cooverexpression of p53 and BCL2 proteins in HPV induce squamous cell carcinomas of the uterine cervix. Gynecol Oncol 2003; 91 (1): 51-58.

  24. Bitiren M, Cakmak EA, Gocmen A, Inaloz SS, Sari I et al. The relationship between expression of p53/BCL-2 and clinicopathologic criteria in cervix squamous cell carcinomas. Eur J Gynecol Oncol 2003; 24 (5): 411-412.

  25. Alameda EFP, Boluda S, Ferrer L, Baro T, Mariñoso L et al. The Ki67 labeling Index is not a useful predictor for the follow up of cervical Intraepithelial Neoplasia-1. J Low Gen Tract Dis 2004; 8 (4): 313-316.

  26. Nagai N. Gene diagnosis of uterine cervical cancer (Article in Japanese). Summary. Rinsho Byori 1994; 42 (4): 372-379.

  27. Petrov SV, Mazurednko NN, Sukhova NM, Moroz IP, Katsenel’son VM et al. Cell oncogene expression in normal, metaplastic, dysplastic epithelium and squamous cell carcinoma of the uterine cervix. Arkh Patol 1994; 56 (4): 22-31. (Article in russian), summary.

  28. Nair SA, Nair MB, Jayaprakash PG, Rajalekshmy TN, Nair MK et al. Ras and c.myc oncoproteins during tumor progression in the uterine cervix. Tumori 1998; 84 (5): 583-588.

  29. Golijow CD, Abba MC, Mouron SA, Gomez MA, Dolout FN. C myc gene amplification detected in preinvasive intraepithelial cervical lesions. Int J Gynecol Cancer 2001; 11 (6): 462-465.

  30. Aoyama C, Peters J, Senadheera S, Llu P, Shimada H. Uterine cervical dysplasia and cancer: identification of C-MYC status by quantitative polymerase chain reaction. Diagn Mol Pathol 1998; 7 (6): 324-330.

  31. Ngan HY et al. Abnormal expression of pan-Ras, C-MYC and p53 in squamous cell carcinoma of the cervix. Correlation with HPV and prognosis. Oncol Rep 2001; 8 (3): 557-561.

  32. Brenna SM, Zeferino LC, Pinto GA, Souza RA, Andrade LA et al. C-MYC protein expression is not an independent prognostic predictor in cervical squamous cell carcinoma. Braz J Med Biol Res 2002; 35 (4): 425-430.

  33. Polischouk AG, Scotnikova OI, Sergeeva NS, Zharinov GM, Lewensohn R et al. Response to radiotherapy of human uterine cervix carcinoma is not correlated with rearrangements of the Ha-ras-1 and/or C-MYC genes. Eur J Cancer 1997; 33 (6): 942-949.

  34. Cho NH, Kim YT, Kim JW. Correlation between G1 cyclins and HPV in the uterine cervix. Int J Gynecol Pathol 1997; 16 (4): 339-347.

  35. Srivatsan ES, Misra BC, Venugopalan M, Wilezynski SP. Loss of heterozigosity for alleles on chromosome II n cervical carcinoma. Am J Hum Genet 1991; 49 (4): 868-877.

  36. Baldin V, Lukas J, Marcote MJ, Pagano M, Draerra G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes and Develop 1993; 7: 812-821.

  37. Brychtova S, Brychta T, Sedlakova E, Kolar Z. Proto-oncogene C-MYC in uterine cervix carcinogenesis. Neoplasma 2004; 51 (2): 84-89.

  38. Uren A, Fallen S, Yuan H, Usubutun A, Kucukali T et al. Activation of the casnonical WNT pathway during genital keratinocyte transformation: a model for cervical cancer progression. Cancer Res 2005; 65 (14): 6199-6206.

  39. Alkushi A, Irving J, Hsu E, Dupuis B, Liu CL et al. Immunoprofile of cervical and endometrial adenocarcinomas isung a tissue microarray. Virchows Arch 2003; 442 (3): 271-277.




2020     |     www.medigraphic.com