Angel G, Castellanos OA, Miranda M

Language: Spanish
References: 14
Page: 9-12
PDF size: 54.33 Kb.

ABSTRACT

Background: Preemptive analgesia, is obtained via aspartate antagonists and glutamate, neurotransmitters released during tissular injury.
Objective Asses preemptive analgesia with dexmedetomidine and consumption of a postanesthesia analgesic.
Material and methods: Male patients, 20-65 years ago were recruited after protocol review and informed consent was obtained. Patients were randomized in three groups, using dexmedetomidine as preemptive analgesia in inguinal hernioplasty.
Results: Subjects had a mean age of 45.3±13.2 yrs. Among patients where dexmedetomidine was administered prior to anesthesia, three had, low heart frequency (60 bpm) and required that analgesia be given for 3.14 hrs. Among patients in whom dexmedetomidine was administered during transanesthesia, two registered low heart frequency (60 bpm.) and required analgesia for 2.27 hrs. In the control group, one patient had a heart frequency of 43 bpm; mean analgesic administration time was 39 minutes. There were no significant variations in arterial pressure. Statistical analysis included Anova, and Student’s T-test to assess analgesia and initial time of analgesia consumption at p ‹ 0.001.
Conclusion: Intravenous dexmedetomidine administered prior to anesthesia decreases pain intensity and consumption of postoperative analgesia.

REFERENCES

1. Paulin DJ, Chen C, Penaloza DA, Polissar NL, Buckley FP. Pain as a factorcomplicating recovery and discharge after ambulatory surgery. AnesthAnalg 2002;95(3):627-634.

2. Katz, J. Brian P y cols. Preemptive Analgesia. Anesth. 1992;77:439-446.

3. Celerier E, Rivat C, Jun Y, Laulin JP, Lancher A, Reynier P, SimonnetG. Long-lasting hiperalgesia induced by fentanyl in rats. Anesth 2000;92:465-72.

4. Belleville JP, Denham SW, Bloor Byron C, Maze M. Effects intravenousdexmedetomidine in Humans. Anesth 1992;77:1125-1133.

5. Yates P, Dewar A, Edwards HN., Fentiman B, Najman J, Richardson V,Fraser J. The prevalence and perception of pain among hospital in-patients.J Of Clin Nur 1998;7(6):521-530.

6. Mikito K, Hiroaki W, Nishikawa K, Takahashi Toshiyuki T, Kozuka Y,Tomoyuki K, Keiichi O, Akiyoshi N. Different mechanisms of developmentand maintenance of experimental incision-induced hyperalgesia in humanskin. Anesth 200297(3):550-559.

7. Nelson LE, Lu J, Guo T, Saper CB, Franks NP, Maze M. The á2 adrenoceptoragonist dexmedetomidina converges on an endogenous sleep- promotingpathway to exert its sedative effects. Anesth 2000;98:428-36.

8. Kanda T, Ohta Y, Kida A, Kemmotsu O. The effect of alpha 2 adrenergicdrugs on the activity of neurons in the rat nucleus raphe magnus in vitro.Anesth analg 1999;88(2):459-461.

9. Eisenach JC. ¿Preemptive Hyperalgesia, Not Analgesia? Anesth2000;92(2):308-309.

10. Groeben H, Mitzner W, Brown RH. Effects of the á2 adrenoceptor agonistdexmedetomidine on bronchoconstriction in dogs. Anesth 2004;100:359-63.

11. Ruesch S, Levy, Jerrold H. Treatment of persistent tachycardia withdexmedetomidine during off pump cardiac surgery. Anesth Analg 2002;95(2):316-318.

12. Wienbroun AA, Ben AR. Dextromethorphan and dexmedetomidine, newagents for the of perioperative pain. Eur J Surg 2001;167:563-9 Internet.

13. Shahabaz RA, Ebert, Thomas J. The efficacy side and recoverycharacteristics of dexmedetomidine versus propofol when used forintraoperative sedation. Anesth Analg 2002;95(2):461-466.

14. Hughes S. The effects of giving patients pre-operative information. NURST 2002;16(28):33-37.