Paz-Estrada C, Capdezúñer-Matos R, Castañeda-Abad RA, Molina SY

Language: Spanish
References: 22
Page: 67-71
PDF size: 60.10 Kb.

ABSTRACT

Objective: To determine the effectiveness of clonidine compared with oral midazolam in hypertensive patients undergoing cholecystectomy. Methods: A longitudinal prospective study was conducted with 120 patients admitted to the hospital «Guillermo Luis Fernández Hernández Baquero» at Holguín, Cuba, from January to May 2005. All patients underwent elective open cholecystectomy and they were classified as physical status II according to the American Society of Anaesthesiologists classification. Participants were divided into two groups. Group I (n = 60) was given 3 µg/kg-1 of clonidine; group II (n = 60) was given 0.5 mg/kg-1 of midazolam. Both drugs were given orally 90 minutes before induction. All participants were induced for general anaesthesia with vecuronium 0.1 mg/kg, then propofol 2 mg/kg^-1 through endotracheal intubation. For the maintenance period the combination oxygen-nitrous oxide, continuous infusion of fentanyl, according to the patient’s need, and infusion of vecuronium (1 ìg/kg^-1/min^-1) were given. Results: The level of sedation, heart rate and mean blood pressure (MBP) were monitored. At the unit of post-anaesthetic care, the MBP of group I was 82 ± 5.1 mgHg compared with the MBP of group II, which was 89 ± 9.2 mm Hg (p ‹ 0.05). Conclusions: Clonidine shifted the haemodynamic variables towards lower values. The secondary effects in group I were, hypotension (22%), bradycardia (10%), dry mouth (18%) and sedation (93.3%); at group II, the secondary effects were hypotension (5%) and sedation (88.3%).

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