2024, Number 3
Antiretroviral treatment guidelines for pediatric HIV patients in Latin America (PLANTAIDS Network): transition from previous regimens to integrase inhibitors
Language: Spanish
References: 9
Page: 106-111
PDF size: 358.44 Kb.
ABSTRACT
PLANTAIDS network, of the Ibero-American Program of Science and Technology for Development (CYTED), is a collaboration between researchers from nine Latin American countries and different institutions around the world focused on the fight against human immunodeficiency virus (HIV) infection in children: Spanish Cohort of HIV-Infected Children and Adolescents (CoRISpe), Italian-Latin American Institute (IiLA), Pediatric European Network for Treatment of AIDS (PENTA) and ESTHER Program of the Spanish Ministry of Health. In the year 2023, members of this network coordinated the PLANTAIDS guidelines to provide evidence-based and/or expert recommendations for all those professionals involved in care of children and adolescents living with HIV in Latin America. This article outlines the recommendations for the transition from the previous antiretroviral regimens to the new regimens based on integrase inhibitors, mainly dolutegravir, which have been proven to be more effective, easier to take and has fewer side effects than alternative drugs that are currently used.REFERENCES
Organización Mundial de la Salud. Transición hacia los nuevos antirretrovirales en los programas contra el VIH: consideraciones clínicas y programáticas. OMS, 2017. [Consultado el 24 de marzo 2023] Disponible en: https://iris.paho.org/bitstream/handle/10665.2/51822/OPSCDE18048_spa.pdf?sequence=1&isAllowed=y
Bacha JM, Dlamini S, Anabwani F, Gwimile J, Kanywa JB, Farirai J et al. Realizing the promise of dolutegravir in effectively treating children and adolescents living with HIV in real-world settings in 6 countries in eastern and Southern Africa. Pediatr Infect Dis J. 2023; 42 (7): 576-581. doi: 10.1097/INF.0000000000003878.
Amuge P, Lugemwa A, Wynne B, Mujuru HA, Violari A, Kityo CM et al. Once-daily dolutegravir-based antiretroviral therapy in infants and children living with HIV from age 4 weeks: results from the below 14 kg cohort in the randomised ODYSSEY trial. Lancet HIV. 2022; 9 (9): e638-e648. doi: 10.1016/S2352-3018(22)00163-1.
Sociedad Española de Infectología Pediátrica. Documento de consenso sobre tratamiento antirretroviral en niños y adolescentes con infección por el virus de la inmunodeficiencia humana. 2022. [Consultado el 15 de abril de 2023] Disponible en: https://www.sanidad.gob.es/ciudadanos/enfLesiones/enfTransmisibles/sida/publicaciones/2022/guias_TAR_ninos_enero_2022_def.pdf
Turkova A, Waalewijn H, Chan MK, Bollen PDJ, Bwakura-Dangarembizi MF, Kekitiinwa AR et al. Dolutegravir twice-daily dosing in children with HIV-associated tuberculosis: a pharmacokinetic and safety study within the open-label, multicentre, randomised, non-inferiority ODYSSEY trial. Lancet HIV. 2022; 9 (9): e627-e637. doi: 10.1016/S2352-3018(22)00160-6.