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Órgano oficial de difusión de la Federación Mexicana de Patología Clínica, AC y de la Asociación Latinoamericana de Patología Clínica/Medicina de Laboratorio

2006, Number 4

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Rev Mex Patol Clin Med Lab 2006; 53 (4)

Hepatitis G. Is it really a threat?

Barba EJR

Language: Spanish
References: 34
Page: 209-228
PDF size: 508.05 Kb.


ABSTRACT

Background: Viral hepatitis as a concept is generally reserved to the hepatic infection caused by a small hepatotrophic group of virus. Five different virus have been identified to have the liver as their main target and in consequence to be capable to produce hepatic disease as their main clinical manifestation. HVA, HBB, HVC, HVD, HVE and HVG. Objective: To review and to document knowledge on the five known virus focusing attention in special form on the discovery and the importance of the HVG. Material and method: This is a revision of scientific and medical literature in which the importance of HVG is documented to the present state, including epidemiology, clinical behavior, laboratorial diagnosis and therapeutic manage of viral hepatitis.
Results: Serum samples of patients with Not-A, Not-B and Not-C hepatitis were used to carry out their molecular amplification and reproduction which lead to the discovery of a new member of the Flaviviridae family: the virus of hepatitis G (HGV). This virus is almost identical to other new reproduced agents that have been designated as virus GB type C; leading to the conclusion that both correspond to the same virus. Discussion: Molecular Biology´s scientific and technological evolution has a definitive impact in the understanding of the physiopathology of viral disease, with epidemiological, clinical and therapeutical implications.


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