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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2023, Number 2

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Rev Biomed 2023; 34 (2)

Clinical applications of miR-2: literature review

Gallardo-Sánchez CA, Rivera-Cameras A, Morán-Moguel MC, Salazar-Páramo M, Dávalos-Rodríguez IP

Language: Spanish
References: 64
Page: 179-190
PDF size: 205.91 Kb.


ABSTRACT

hsa-micro RNA-21 (miR-21) is one of the most studied micro RNAs due to the large number of processes in which it is involved and cells where it is expressed. Although most of the research has been directed towards its role in cancer, it has been found to be a relevant element in both physiological and pathological processes of virtually every system. This descriptive review summarizes the most recent research done regarding its biological functions and the potential clinical applications as a biomarker and therapeutic target. A search for “hsa-miR-21” or “miR-21” was performed in PubMed database, and the 50 most recent original articles were selected, with no more than 5 focusing on a single system or area of specialty. The review provides a general assessment of the ways this molecule influences health and the benefits its research could provide in the future to the survival and quality of life of a variety of patients.


REFERENCES

  1. Wang S, Wan X, Ruan Q. The MicroRNA-21 inAutoimmune Diseases. Int J Mol Sci. 2016 Jun3;17(6):864. doi: 10.3390/ijms17060864. PMID: 27271606; PMCID: PMC4926398.

  2. Saliminejad K, Khorram Khorshid HR, Soleymani FardS, Ghaffari SH. An overview of microRNAs: Biology,functions, therapeutics, and analysis methods. J CellPhysiol. 2019 May;234(5):5451-5465. doi: 10.1002/jcp.27486. Epub 2018 Nov 23. PMID: 30471116.

  3. Desvignes T, Batzel P, Berezikov E, Eilbeck K, EppigJT, McAndrews MS, Singer A, Postlethwait JH. miRNANomenclature: A View Incorporating Genetic Origins,Biosynthetic Pathways, and Sequence Variants. TrendsGenet. 2015 Nov;31(11):613-626. doi: 10.1016/j.tig.2015.09.002. Epub 2015 Oct 8. PMID: 26453491;PMCID: PMC4639415.

  4. Lawrie CH. MicroRNAs: A brief introduction. In:MicroRNAs in Medicine. Lawrie CH (Ed). John Wiley& Sons, Inc. (Singapore). 2014. pp.1-24.

  5. Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T.Identification of novel genes coding for small expressedRNAs. Science. 2001 Oct 26;294(5543):853-8. doi:10.1126/science.1064921. PMID: 11679670.

  6. Kumarswamy R, Volkmann I, Thum T. Regulationand function of miRNA-21 in health and disease.RNA Biol. 2011 Sep-Oct;8(5):706-13. doi: 10.4161/rna.8.5.16154. Epub 2011 Jul 7. PMID: 21712654;PMCID: PMC3256347.

  7. Huang Z, Shi J, Gao Y, Cui C, Zhang S, Li J, Zhou Y, CuiQ. HMDD v3.0: a database for experimentally supportedhuman microRNA-disease associations. Nucleic AcidsRes. 2019 Jan 8;47(D1):D1013-D1017. doi: 10.1093/nar/gky1010. PMID: 30364956; PMCID: PMC6323994.

  8. Chen Y, Wang X. miRDB: an online database forprediction of functional microRNA targets. NucleicAcids Res. 2020 Jan 8;48(D1):D127-D131. doi: 10.1093/nar/gkz757. PMID: 31504780; PMCID: PMC6943051.

  9. Bartman CM, Oyama Y, Brodsky K, Khailova L,Walker L, Koeppen M et al. Intense light-elicitedupregulation of miR-21 facilitates glycolysis andcardioprotection through Per2-dependent mechanisms.PLoS One. 2017 Apr 27;12(4):e0176243. doi: 10.1371/journal.pone.0176243. PMID: 28448534; PMCID:PMC5407766.

  10. Li et al. HMDD v2.0: a database for experimentallysupported human microRNA and disease associations.Nucleic Acids Res. 2014 Jan;42(Databaseissue):D1070-4.

  11. Rufino-Palomares EE, Reyes-Zurita FJ, Lupiáñez JA,Medina PP. MicroRNAs as Oncogenes and TumorSuppressors. En: MicroRNAs in Medicine. LawrieCH (Ed). John Wiley & Sons, Inc. (Singapore). 2014.pp.223-243.

  12. Wang W, Li X, Liu C, Zhang X, Wu Y, Diao M, Tan S,Huang S, Cheng Y, You T. MicroRNA-21 as a diagnosticand prognostic biomarker of lung cancer: a systematicreview and meta-analysis. Biosci Rep. 2022 May27;42(5): BSR20211653. doi: 10.1042/BSR20211653.PMID: 35441676; PMCID: PMC9093699.

  13. Javanmardi S, Aghamaali MR, Abolmaali SS,Mohammadi S, Tamaddon AM. miR-21, An OncogenicTarget miRNA for Cancer Therapy: MolecularMechanisms and Recent Advancements in Chemo andRadio-resistance. Curr Gene Ther. 2017;16(6):375-389.doi: 10.2174/1566523217666170102105119. PMID:28042781.

  14. Alexandre D, Teixeira B, Rico A, Valente S, CraveiroA, Baptista PV et al. Molecular Beacon for DetectionmiRNA-21 as a Biomarker of Lung Cancer. Int J Mol Sci.2022 Mar 19;23(6):3330. doi: 10.3390/ijms23063330.PMID: 35328750; PMCID: PMC8955680.

  15. Qiu L, Weng G. The diagnostic value of serum miR-21in patients with ovarian cancer: a systematic review andmeta-analysis. J Ovarian Res. 2022 May 2;15(1):51.doi: 10.1186/s13048-022-00985-3. PMID: 35501921;PMCID: PMC9059364.

  16. Dioguardi M, Spirito F, Sovereto D, Alovisi M, TroianoG, Aiuto R, Garcovich D, Crincoli V, Laino L, CazzollaAP, Caloro GA, Di Cosola M, Lo Muzio L. MicroRNA21 Expression as a Prognostic Biomarker in Oral Cancer:Systematic Review and Meta-Analysis. Int J EnvironRes Public Health. 2022 Mar 14;19(6):3396. doi:10.3390/ijerph19063396. PMID: 35329083; PMCID:PMC8948874.

  17. Sheng S, Su W, Mao D, Li C, Hu X, Deng W, Yao Y, Ji Y.MicroRNA-21 induces cisplatin resistance in head andneck squamous cell carcinoma. PLoS One. 2022. Apr14;17(4):e0267017. doi: 10.1371/journal.pone.0267017.PMID: 35421166; PMCID: PMC9009694.

  18. Yang P, Dong X, Zhang Y. MicroRNA profiles in plasmasamples from young metabolically healthy obese patientsand miRNA-21 are associated with diastolic dysfunctionvia TGF-β1/Smad pathway. J Clin Lab Anal. 2020Jun;34(6):e23246. doi: 10.1002/jcla.23246. Epub 2020Feb 28. PMID: 32108968; PMCID: PMC7307369.

  19. Liu W, Li Y, Zhao D. Modulation of Vascular SmoothMuscle Cell Multiplication, Apoptosis, and InflammatoryDamage by miR-21 in Coronary Heart Disease. ComputMath Methods Med. 2021 Nov 27; 2021:6942699. doi:10.1155/2021/6942699. PMID: 34873417; PMCID:PMC8643245.

  20. Chen H, Zhang F, Zhang YL, Yang XC. Relationshipbetween circulating miRNA-21, atrial fibrosis, andatrial fibrillation in patients with atrial enlargement.Ann Palliat Med. 2021 Dec;10(12):12742-12749. doi:10.21037/apm-21-3518. PMID: 35016439.

  21. Tao L, Huang X, Xu M, Qin Z, Zhang F, Hua F et al. Valueof circulating miRNA-21 in the diagnosis of subclinicaldiabetic cardiomyopathy. Mol Cell Endocrinol. 2020Dec 1; 518:110944. doi: 10.1016/j.mce.2020.110944.Epub 2020 Jul 24. PMID: 32717421.

  22. He W, Zhu L, Huang Y, Zhang Y, Shen W, Fang L etal. The relationship of MicroRNA-21 and plaquestability in acute coronary syndrome. Medicine(Baltimore). 2019 Nov;98(47):e18049. doi: 10.1097/MD.0000000000018049. PMID: 31764830; PMCID:PMC6882643.

  23. Schober A, Blay RM, Saboor Maleki S, Zahedi F,Winklmaier AE, Kakar MY et al. MicroRNA-21 ControlsCircadian Regulation of Apoptosis in AtheroscleroticLesions. Circulation. 2021 Sep 28;144(13):1059-1073.doi: 10.1161/CIRCULATIONAHA.120.051614. Epub2021 Jul 8. PMID: 34233454.

  24. Kilari S, Cai C, Zhao C, Sharma A, Chernogubova E,Simeon M et al. The Role of MicroRNA-21 in VenousNeointimal Hyperplasia: Implications for Targeting miR-21 for VNH Treatment. Mol Ther. 2019 Sep 4;27(9):1681-1693. doi: 10.1016/j.ymthe.2019.06.011. Epub 2019 Jul3. PMID: 31326400; PMCID: PMC6731518.

  25. Wang J, Wu M. The up-regulation of miR-21 by gastrodinto promote the angiogenesis ability of human umbilicalvein endothelial cells by activating the signaling pathwayof PI3K/Akt. Bioengineered. 2021 Dec;12(1):5402-5410. doi: 10.1080/21655979.2021.1964895. PMID:34424813; PMCID: PMC8806924.

  26. Lyall GK, Davies MJ, Ferguson C, Porter KE, Birch KM.In-exercise vascular shear rate during acute continuousand interval exercise: impact on endothelial function andmiR-21. J Appl Physiol (1985). 2019 Dec 1;127(6):1754-1762. doi: 10.1152/japplphysiol.00156.2019. Epub 2019Oct 10. PMID: 31600098.

  27. Go H, Maeda H, Miyazaki K, Maeda R, Kume Y,Namba F et al. Extracellular vesicle miRNA-21 is apotential biomarker for predicting chronic lung diseasein premature infants. Am J Physiol Lung Cell MolPhysiol. 2020 May 1;318(5): L845-L851. doi: 10.1152/ajplung.00166.2019. Epub 2020 Mar 19. PMID:32191117.

  28. Liu R, Zhao G, Wang Q, Gong F. Prognostic value ofpulmonary ultrasound score combined with plasmamiR-21-3p expression in patients with acute lung injury.J Clin Lab Anal. 2022 Mar;36(3):e24275. doi: 10.1002/jcla.24275. Epub 2022 Feb 10. PMID: 35141939;PMCID: PMC8906047.

  29. Ge J, Yao Y, Jia H, Li P, Sun W. Inhibition of miR-21 ameliorates LPS-induced acute lung injurythrough increasing B cell lymphoma-2 expression.Innate Immun. 2020 Nov;26(8):693-702. doi:10.1177/1753425920942574. Epub 2020 Jul 29. PMID:32727244; PMCID: PMC7787552.

  30. Bozzini S, Pandolfi L, Rossi E, Inghilleri S, ZorzettoM, Ferrario G et al. miRNAs Potentially Involved inPost Lung Transplant-Obliterative Bronchiolitis: TheRole of miR-21-5p. Cells. 2021 Mar 20;10(3):688. doi:10.3390/cells10030688. PMID: 33804639; PMCID:PMC8003603.

  31. Lange T, Artelt N, Kindt F, Stracke S, Rettig R, LendeckelU, Chadjichristos CE, Kavvadas P, Chatziantoniou C,Endlich K, Endlich N. MiR-21 is up-regulated in urinaryexosomes of chronic kidney disease patients and afterglomerular injury. J Cell Mol Med. 2019 Jul;23(7):4839-4843. doi: 10.1111/jcmm.14317. Epub 2019 May 7.PMID: 31066165; PMCID: PMC6584549.

  32. Wu R, Zhou S, Liu M, An H, Wang Z, Liu T. ClinicalSignificance of miR-21-5p in Predicting Occurrence andProgression of Uremic Vascular Calcification in Patientswith End-Stage Renal Disease. Yonsei Med J. 2022Mar;63(3):252-258. doi: 10.3349/ymj.2022.63.3.252.PMID: 35184427; PMCID: PMC8860934.

  33. Parrish A, Srivastava A, Juskeviciute E, Hoek JB,Vadigepalli R. Dysregulation of miR-21-associatedmiRNA regulatory networks by chronic ethanolconsumption impairs liver regeneration. PhysiolGenomics. 2021 Dec 1;53(12):546-555. doi: 10.1152/physiolgenomics.00113.2021. Epub 2021 Nov 19.PMID: 34796728; PMCID: PMC8820682.

  34. Makhmudi A, Kalim AS, Gunadi. microRNA-21expressions impact on liver fibrosis in biliary atresiapatients. BMC Res Notes. 2019 Mar 29;12(1):189.doi: 10.1186/s13104-019-4227-y. PMID: 30925941;PMCID: PMC6441216.

  35. Xiong Y, Tang Y, Fan F, Zeng Y, Li C, Zhou G et al.Exosomal hsa-miR-21-5p derived from growth hormonesecretingpituitary adenoma promotes abnormal boneformation in acromegaly. Transl Res. 2020 Jan; 215:1-16. doi: 10.1016/j.trsl.2019.07.013. Epub 2019 Aug 10.PMID: 31469974.

  36. Zou YC, Gao YP, Yin HD, Liu G. Serum miR-21expression correlates with radiographic progression butalso low bone mineral density in patients with ankylosingspondylitis: a cross-sectional study. Innate Immun. 2019Jul;25(5):314-321. doi: 10.1177/1753425919842932.Epub 2019 Apr 18. PMID: 30997863; PMCID:PMC6830902.

  37. Suarjana IN, Isbagio H, Soewondo P, Rachman IA,Sadikin M, Prihartono J et al. The Role of SerumExpression Levels of Microrna-21 on Bone MineralDensity in Hypostrogenic Postmenopausal Womenwith Osteoporosis: Study on Level of RANKL, OPG,TGFβ-1, Sclerostin, RANKL/OPG Ratio, and PhysicalActivity. Acta Med Indones. 2019 Jul;51(3):245-252.PMID: 31699948.

  38. Weng PW, Yadav VK, Pikatan NW, Fong IH, Lin IH,Yeh CT et al. Novel NFκB Inhibitor SC75741 MitigatesChondrocyte Degradation and Prevents ActivatedFibroblast Transformation by Modulating miR-21/GDF-5/SOX5 Signaling. Int J Mol Sci. 2021 Oct14;22(20):11082. doi: 10.3390/ijms222011082. PMID:34681754; PMCID: PMC8538686.

  39. La Sala L, Mrakic-Sposta S, Tagliabue E, Prattichizzo F,Micheloni S, Sangalli E et al. Circulating microRNA-21is an early predictor of ROS-mediated damage in subjectswith high risk of developing diabetes and in drug-naïveT2D. Cardiovasc Diabetol. 2019 Feb 25;18(1):18.doi: 10.1186/s12933-019-0824-2. PMID: 30803440;PMCID: PMC6388471.

  40. Huang C, Luo W, Wang Q, Ye Y, Fan J, Lin L et al. Humanmesenchymal stem cells promote ischemic repairmentand angiogenesis of diabetic foot through exosomemiRNA-21-5p. Stem Cell Res. 2021 Apr;52:102235.doi: 10.1016/j.scr.2021.102235. Epub 2021 Feb 11.PMID: 33601096.

  41. Chang WT, Huang TL, Chen ZC, Feng YH. TheExpression of MicroRNA-21 in Bone Marrow Fluid isan Indicator of Hematological Disorders and Mortality.Asian Pac J Cancer Prev. 2020 Oct 1;21(10):2817-2821. doi: 10.31557/APJCP.2020.21.10.2817. PMID:33112535; PMCID: PMC7798149.

  42. Mirza MAB, Guru SA, Abdullah SM, Rizvi A, Saxena A.microRNA-21 Expression as Prognostic and TherapeuticResponse Marker in Chronic Myeloid LeukaemiaPatients. Asian Pac J Cancer Prev. 2019 Aug 1;20(8):2379-2383. doi: 10.31557/APJCP.2019.20.8.2379. PMID:31450909; PMCID: PMC6852824.

  43. Moussa Agha D, Rouas R, Najar M, Bouhtit F, Fayyad-Kazan H, Lagneaux L et al. Impact of Bone MarrowmiR-21 Expression on Acute Myeloid Leukemia TLymphocyte Fragility and Dysfunction. Cells. 2020Sep 8;9(9):2053. doi: 10.3390/cells9092053. PMID:32911844; PMCID: PMC7563595.

  44. Zhan L, Pang Y, Jiang H, Zhang S, Jin H, Chen J et al.Butylphthalide Inhibits TLR4/NF-κB Pathwayby Upregulation of miR-21 to Have the NeuroprotectiveEffect. J Healthc Eng. 2022 Jan 7; 2022:4687349. doi:10.1155/2022/4687349. PMID: 35035839; PMCID:PMC8759846.

  45. Xiao G, Huang B, Guo M, Long C, Li P, Zhong Bet al. Long non-coding RNA BRCAT54 spongesmicroRNA-21 in vestibular schwannoma to suppresscell proliferation. Bioengineered. 2022 Feb;13(2):4301-4308. doi: 10.1080/21655979.2022.2031410. PMID:35137654; PMCID: PMC8973964.

  46. Xiong Y, Xiong Y, Zhang H, Zhao Y, Han K, Zhang J et al.hPMSCs-Derived Exosomal miRNA-21 Protects AgainstAging-Related Oxidative Damage of CD4+ T Cells by Targeting the PTEN/PI3K-Nrf2 Axis.Front Immunol. 2021 Nov 23; 12:780897. doi: 10.3389/fimmu.2021.780897. PMID: 34887868; PMCID:PMC8649962.

  47. Tangtanatakul P, Klinchanhom S, Sodsai P, Sutichet T,Promjeen C, Avihingsanon Y et al. Down-regulationof let-7a and miR-21 in urine exosomes from lupusnephritis patients during disease flare. Asian Pac J AllergyImmunol. 2019 Dec;37(4):189-197. doi: 10.12932/AP-130318-0280. PMID: 30118248.

  48. Zhang R, Wu L, Zhang HJ, Gao XJ, Pan XT, WangXR et al. Expression levels of plasma miRNA-21 andNT-proBNP in children with Kawasaki disease andtheir clinical significance. Eur Rev Med PharmacolSci. 2020 Dec;24(24):12757-12762. doi: 10.26355/eurrev_202012_24175. PMID: 33378024.

  49. Nuñez-Borque E, Fernandez-Bravo S, Rodriguez DelRio P, Alwashali EM, Lopez-Dominguez D, Gutierrez-Blazquez MD et al. Increased miR-21-3p and miR487b-3p serum levels during anaphylactic reaction infood allergic children. Pediatr Allergy Immunol. 2021Aug;32(6):1296-1306. doi: 10.1111/pai.13518. Epub2021 May 7. PMID: 33876465; PMCID: PMC8453890.

  50. Lu J, Liu D, Tan Y, Deng F, Li R. M1 Macrophageexosomes MiR-21a-5p aggravates inflammatory boweldisease through decreasing E-cadherin and subsequentILC2 activation. J Cell Mol Med. 2021 Mar;25(6):3041-3050. doi: 10.1111/jcmm.16348. Epub 2021 Feb 10.PMID: 33569850; PMCID: PMC7957199.

  51. Yildirim E, Ermis E, Allahverdiyev S, Ucar H, YavuzerS, Cengiz M. Circulating miR-21 levels in hypertensivepatients with asymptomatic organ damage. Medicine(Baltimore). 2019 Sep;98(39): e17297. doi: 10.1097/MD.0000000000017297. PMID: 31574853; PMCID:PMC6775376.

  52. Kara SP, Ozkan G, Yılmaz A, Bayrakçı N, Güzel S,Geyik E. MicroRNA 21 and microRNA 155 levelsin resistant hypertension, and their relationships withaldosterone. Ren Fail. 2021 Dec;43(1):676-683. doi:10.1080/0886022X.2021.1915800. PMID: 33888045;PMCID: PMC8078961.

  53. Barbu MG, Condrat CE, Thompson DC, Bugnar OL,Cretoiu D, Toader OD, Suciu N, Voinea SC. MicroRNAInvolvement in Signaling Pathways During ViralInfection. Front Cell Dev Biol. 2020 Mar 10;8:143. Doi:10.3389/fcell.2020.00143. PMID: 32211411; PMCID:PMC7075948

  54. He G, Ding J, Zhang Y, Cai M, Yang J, Cho WC etal. microRNA-21: a key modulator in oncogenic viralinfections. RNA Biol. 2021 May;18(5):809-817. doi:10.1080/15476286.2021.1880756. Epub 2021 Mar 22.PMID: 33499700; PMCID: PMC8078529.

  55. Pandey N, Rastogi M, Singh SK. Chandipura virusdysregulates the expression of hsa-miR-21-5p to activateNF-κB in human microglial cells. J Biomed Sci. 2021 Jul7;28(1):52. doi: 10.1186/s12929-021-00748-0. PMID:34233673; PMCID: PMC8265105.

  56. Shi J, Feng P, Gu T. MicroRNA-21-3p modulates FGF2 tofacilitate influenza A virus H5N1 replication by refrainingtype I interferon response. Biosci Rep. 2020 May29;40(5): BSR20200158. doi: 10.1042/BSR20200158.PMID: 32432671; PMCID: PMC7256676.

  57. Castro-Leyva V, Arenas-Huertero F, Espejel-NúñezA, Giono Cerezo S, Flores-Pliego A, Espino Y SosaS et al. miR-21 differentially regulates IL-1β and IL-10 expression in human decidual cells infected withstreptococcus B. Reprod Biol. 2022 Mar;22(1):100604.doi: 10.1016/j.repbio.2022.100604. Epub 2022 Jan 13.PMID: 35033900.

  58. Na L, Ding H, Xing E, Zhang Y, Gao J, Liu B et al. Thepredictive value of microRNA-21 for sepsis risk and itscorrelation with disease severity, systemic inflammation,and 28-day mortality in sepsis patients. J Clin Lab Anal.2020 Mar;34(3):e23103. doi: 10.1002/jcla.23103. Epub2019 Nov 28. PMID: 31778243; PMCID: PMC7083453

  59. Jazbutyte V, Thum T. MicroRNA-21: from cancerto cardiovascular disease. Curr Drug Targets. 2010Aug;11(8):926-35. doi: 10.2174/138945010791591403.PMID: 20415649.

  60. Fitzgerald JB, George J, Christenson LK. Non-codingRNA in Ovarian Development and Disease. Adv ExpMed Biol. 2016;886:79-93. doi: 10.1007/978-94-017-7417-8_5. PMID: 26659488; PMCID: PMC5535786.

  61. Ma R, Li X, Tewari N, Liu Y, Bhawal UK, Zeng X.microRNA-21 ameliorates the impairment of autophagyin palatal wound healing. J Physiol Pharmacol. 2020Dec;71(6). doi: 10.26402/jpp.2020.6.14. Epub 2021 Apr22. PMID: 33902001.

  62. Liu R, Du J, Zhou J, Zhong B, Ba L, Zhang J et al. ElevatedmicroRNA-21 Is a Brake of Inflammation Involved inthe Development of Nasal Polyps. Front Immunol. 2021Apr 15; 12:530488. doi: 10.3389/fimmu.2021.530488.PMID: 33936025; PMCID: PMC8082185.

  63. Shchurevska OD, Zhuk SI. Assessment of correlationbetween mirnas-21-3p and -210-3p expression inmaternal and umbilical cord plasma and fetal weight atbirth. Wiad Lek. 2021;74(2):236-240. PMID: 33813478.

  64. Hu L, Han D, Yu D, Ao D, Yang Z. Circulating BloodmiR-155 and miR-21 Promote the Development ofAcute Pancreatitis and Can Be Used to Assess the RiskStratification of Pancreatitis. J Healthc Eng. 2021 Dec14; 2021:2064162. doi: 10.1155/2021/2064162. PMID:34950438; PMCID: PMC8692001.




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