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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2023, Número 2

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Rev Biomed 2023; 34 (2)


Aplicaciones clínicas de miR-21: revisión de la literatura

Gallardo-Sánchez CA, Rivera-Cameras A, Morán-Moguel MC, Salazar-Páramo M, Dávalos-Rodríguez IP

Idioma: Español
Referencias bibliográficas: 64
Paginas: 179-190
Archivo PDF: 205.91 Kb.


RESUMEN

hsa-micro RNA-21 (miR-21) es uno de los micro-RNA más estudiados debido al gran número de procesos biológicos en los que está involucrado y células en donde se expresa. Aunque la mayor parte de la investigación se ha centrado en el papel de miR-21 en cáncer, también se ha descrito que es una molécula reguladora relevante en diversos procesos fisiológicos y patológicos de prácticamente todos los sistemas. El objetivo de esta revisión descriptiva es presentar algunos de los avances en el conocimiento de las funciones y aplicaciones clínicas de miR-21 como biomarcador y blanco terapéutico. Se realizó una búsqueda de “hsa-miR-21” o “miR-21” en la base de datos PubMed. Se incluyeron los 50 artículos originales más recientes publicados en idioma inglés. La selección se limitó a no más de cinco publicaciones que se enfocaran en un solo órgano o sistema o área de especialidad clínica. Esta revisión proporciona una visión general de las formas en que esta molécula influye en la salud y los beneficios que su investigación podría proporcionar en el futuro para mejorar la atención y calidad de vida de una variedad de pacientes.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Wang S, Wan X, Ruan Q. The MicroRNA-21 inAutoimmune Diseases. Int J Mol Sci. 2016 Jun3;17(6):864. doi: 10.3390/ijms17060864. PMID: 27271606; PMCID: PMC4926398.

  2. Saliminejad K, Khorram Khorshid HR, Soleymani FardS, Ghaffari SH. An overview of microRNAs: Biology,functions, therapeutics, and analysis methods. J CellPhysiol. 2019 May;234(5):5451-5465. doi: 10.1002/jcp.27486. Epub 2018 Nov 23. PMID: 30471116.

  3. Desvignes T, Batzel P, Berezikov E, Eilbeck K, EppigJT, McAndrews MS, Singer A, Postlethwait JH. miRNANomenclature: A View Incorporating Genetic Origins,Biosynthetic Pathways, and Sequence Variants. TrendsGenet. 2015 Nov;31(11):613-626. doi: 10.1016/j.tig.2015.09.002. Epub 2015 Oct 8. PMID: 26453491;PMCID: PMC4639415.

  4. Lawrie CH. MicroRNAs: A brief introduction. In:MicroRNAs in Medicine. Lawrie CH (Ed). John Wiley& Sons, Inc. (Singapore). 2014. pp.1-24.

  5. Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T.Identification of novel genes coding for small expressedRNAs. Science. 2001 Oct 26;294(5543):853-8. doi:10.1126/science.1064921. PMID: 11679670.

  6. Kumarswamy R, Volkmann I, Thum T. Regulationand function of miRNA-21 in health and disease.RNA Biol. 2011 Sep-Oct;8(5):706-13. doi: 10.4161/rna.8.5.16154. Epub 2011 Jul 7. PMID: 21712654;PMCID: PMC3256347.

  7. Huang Z, Shi J, Gao Y, Cui C, Zhang S, Li J, Zhou Y, CuiQ. HMDD v3.0: a database for experimentally supportedhuman microRNA-disease associations. Nucleic AcidsRes. 2019 Jan 8;47(D1):D1013-D1017. doi: 10.1093/nar/gky1010. PMID: 30364956; PMCID: PMC6323994.

  8. Chen Y, Wang X. miRDB: an online database forprediction of functional microRNA targets. NucleicAcids Res. 2020 Jan 8;48(D1):D127-D131. doi: 10.1093/nar/gkz757. PMID: 31504780; PMCID: PMC6943051.

  9. Bartman CM, Oyama Y, Brodsky K, Khailova L,Walker L, Koeppen M et al. Intense light-elicitedupregulation of miR-21 facilitates glycolysis andcardioprotection through Per2-dependent mechanisms.PLoS One. 2017 Apr 27;12(4):e0176243. doi: 10.1371/journal.pone.0176243. PMID: 28448534; PMCID:PMC5407766.

  10. Li et al. HMDD v2.0: a database for experimentallysupported human microRNA and disease associations.Nucleic Acids Res. 2014 Jan;42(Databaseissue):D1070-4.

  11. Rufino-Palomares EE, Reyes-Zurita FJ, Lupiáñez JA,Medina PP. MicroRNAs as Oncogenes and TumorSuppressors. En: MicroRNAs in Medicine. LawrieCH (Ed). John Wiley & Sons, Inc. (Singapore). 2014.pp.223-243.

  12. Wang W, Li X, Liu C, Zhang X, Wu Y, Diao M, Tan S,Huang S, Cheng Y, You T. MicroRNA-21 as a diagnosticand prognostic biomarker of lung cancer: a systematicreview and meta-analysis. Biosci Rep. 2022 May27;42(5): BSR20211653. doi: 10.1042/BSR20211653.PMID: 35441676; PMCID: PMC9093699.

  13. Javanmardi S, Aghamaali MR, Abolmaali SS,Mohammadi S, Tamaddon AM. miR-21, An OncogenicTarget miRNA for Cancer Therapy: MolecularMechanisms and Recent Advancements in Chemo andRadio-resistance. Curr Gene Ther. 2017;16(6):375-389.doi: 10.2174/1566523217666170102105119. PMID:28042781.

  14. Alexandre D, Teixeira B, Rico A, Valente S, CraveiroA, Baptista PV et al. Molecular Beacon for DetectionmiRNA-21 as a Biomarker of Lung Cancer. Int J Mol Sci.2022 Mar 19;23(6):3330. doi: 10.3390/ijms23063330.PMID: 35328750; PMCID: PMC8955680.

  15. Qiu L, Weng G. The diagnostic value of serum miR-21in patients with ovarian cancer: a systematic review andmeta-analysis. J Ovarian Res. 2022 May 2;15(1):51.doi: 10.1186/s13048-022-00985-3. PMID: 35501921;PMCID: PMC9059364.

  16. Dioguardi M, Spirito F, Sovereto D, Alovisi M, TroianoG, Aiuto R, Garcovich D, Crincoli V, Laino L, CazzollaAP, Caloro GA, Di Cosola M, Lo Muzio L. MicroRNA21 Expression as a Prognostic Biomarker in Oral Cancer:Systematic Review and Meta-Analysis. Int J EnvironRes Public Health. 2022 Mar 14;19(6):3396. doi:10.3390/ijerph19063396. PMID: 35329083; PMCID:PMC8948874.

  17. Sheng S, Su W, Mao D, Li C, Hu X, Deng W, Yao Y, Ji Y.MicroRNA-21 induces cisplatin resistance in head andneck squamous cell carcinoma. PLoS One. 2022. Apr14;17(4):e0267017. doi: 10.1371/journal.pone.0267017.PMID: 35421166; PMCID: PMC9009694.

  18. Yang P, Dong X, Zhang Y. MicroRNA profiles in plasmasamples from young metabolically healthy obese patientsand miRNA-21 are associated with diastolic dysfunctionvia TGF-β1/Smad pathway. J Clin Lab Anal. 2020Jun;34(6):e23246. doi: 10.1002/jcla.23246. Epub 2020Feb 28. PMID: 32108968; PMCID: PMC7307369.

  19. Liu W, Li Y, Zhao D. Modulation of Vascular SmoothMuscle Cell Multiplication, Apoptosis, and InflammatoryDamage by miR-21 in Coronary Heart Disease. ComputMath Methods Med. 2021 Nov 27; 2021:6942699. doi:10.1155/2021/6942699. PMID: 34873417; PMCID:PMC8643245.

  20. Chen H, Zhang F, Zhang YL, Yang XC. Relationshipbetween circulating miRNA-21, atrial fibrosis, andatrial fibrillation in patients with atrial enlargement.Ann Palliat Med. 2021 Dec;10(12):12742-12749. doi:10.21037/apm-21-3518. PMID: 35016439.

  21. Tao L, Huang X, Xu M, Qin Z, Zhang F, Hua F et al. Valueof circulating miRNA-21 in the diagnosis of subclinicaldiabetic cardiomyopathy. Mol Cell Endocrinol. 2020Dec 1; 518:110944. doi: 10.1016/j.mce.2020.110944.Epub 2020 Jul 24. PMID: 32717421.

  22. He W, Zhu L, Huang Y, Zhang Y, Shen W, Fang L etal. The relationship of MicroRNA-21 and plaquestability in acute coronary syndrome. Medicine(Baltimore). 2019 Nov;98(47):e18049. doi: 10.1097/MD.0000000000018049. PMID: 31764830; PMCID:PMC6882643.

  23. Schober A, Blay RM, Saboor Maleki S, Zahedi F,Winklmaier AE, Kakar MY et al. MicroRNA-21 ControlsCircadian Regulation of Apoptosis in AtheroscleroticLesions. Circulation. 2021 Sep 28;144(13):1059-1073.doi: 10.1161/CIRCULATIONAHA.120.051614. Epub2021 Jul 8. PMID: 34233454.

  24. Kilari S, Cai C, Zhao C, Sharma A, Chernogubova E,Simeon M et al. The Role of MicroRNA-21 in VenousNeointimal Hyperplasia: Implications for Targeting miR-21 for VNH Treatment. Mol Ther. 2019 Sep 4;27(9):1681-1693. doi: 10.1016/j.ymthe.2019.06.011. Epub 2019 Jul3. PMID: 31326400; PMCID: PMC6731518.

  25. Wang J, Wu M. The up-regulation of miR-21 by gastrodinto promote the angiogenesis ability of human umbilicalvein endothelial cells by activating the signaling pathwayof PI3K/Akt. Bioengineered. 2021 Dec;12(1):5402-5410. doi: 10.1080/21655979.2021.1964895. PMID:34424813; PMCID: PMC8806924.

  26. Lyall GK, Davies MJ, Ferguson C, Porter KE, Birch KM.In-exercise vascular shear rate during acute continuousand interval exercise: impact on endothelial function andmiR-21. J Appl Physiol (1985). 2019 Dec 1;127(6):1754-1762. doi: 10.1152/japplphysiol.00156.2019. Epub 2019Oct 10. PMID: 31600098.

  27. Go H, Maeda H, Miyazaki K, Maeda R, Kume Y,Namba F et al. Extracellular vesicle miRNA-21 is apotential biomarker for predicting chronic lung diseasein premature infants. Am J Physiol Lung Cell MolPhysiol. 2020 May 1;318(5): L845-L851. doi: 10.1152/ajplung.00166.2019. Epub 2020 Mar 19. PMID:32191117.

  28. Liu R, Zhao G, Wang Q, Gong F. Prognostic value ofpulmonary ultrasound score combined with plasmamiR-21-3p expression in patients with acute lung injury.J Clin Lab Anal. 2022 Mar;36(3):e24275. doi: 10.1002/jcla.24275. Epub 2022 Feb 10. PMID: 35141939;PMCID: PMC8906047.

  29. Ge J, Yao Y, Jia H, Li P, Sun W. Inhibition of miR-21 ameliorates LPS-induced acute lung injurythrough increasing B cell lymphoma-2 expression.Innate Immun. 2020 Nov;26(8):693-702. doi:10.1177/1753425920942574. Epub 2020 Jul 29. PMID:32727244; PMCID: PMC7787552.

  30. Bozzini S, Pandolfi L, Rossi E, Inghilleri S, ZorzettoM, Ferrario G et al. miRNAs Potentially Involved inPost Lung Transplant-Obliterative Bronchiolitis: TheRole of miR-21-5p. Cells. 2021 Mar 20;10(3):688. doi:10.3390/cells10030688. PMID: 33804639; PMCID:PMC8003603.

  31. Lange T, Artelt N, Kindt F, Stracke S, Rettig R, LendeckelU, Chadjichristos CE, Kavvadas P, Chatziantoniou C,Endlich K, Endlich N. MiR-21 is up-regulated in urinaryexosomes of chronic kidney disease patients and afterglomerular injury. J Cell Mol Med. 2019 Jul;23(7):4839-4843. doi: 10.1111/jcmm.14317. Epub 2019 May 7.PMID: 31066165; PMCID: PMC6584549.

  32. Wu R, Zhou S, Liu M, An H, Wang Z, Liu T. ClinicalSignificance of miR-21-5p in Predicting Occurrence andProgression of Uremic Vascular Calcification in Patientswith End-Stage Renal Disease. Yonsei Med J. 2022Mar;63(3):252-258. doi: 10.3349/ymj.2022.63.3.252.PMID: 35184427; PMCID: PMC8860934.

  33. Parrish A, Srivastava A, Juskeviciute E, Hoek JB,Vadigepalli R. Dysregulation of miR-21-associatedmiRNA regulatory networks by chronic ethanolconsumption impairs liver regeneration. PhysiolGenomics. 2021 Dec 1;53(12):546-555. doi: 10.1152/physiolgenomics.00113.2021. Epub 2021 Nov 19.PMID: 34796728; PMCID: PMC8820682.

  34. Makhmudi A, Kalim AS, Gunadi. microRNA-21expressions impact on liver fibrosis in biliary atresiapatients. BMC Res Notes. 2019 Mar 29;12(1):189.doi: 10.1186/s13104-019-4227-y. PMID: 30925941;PMCID: PMC6441216.

  35. Xiong Y, Tang Y, Fan F, Zeng Y, Li C, Zhou G et al.Exosomal hsa-miR-21-5p derived from growth hormonesecretingpituitary adenoma promotes abnormal boneformation in acromegaly. Transl Res. 2020 Jan; 215:1-16. doi: 10.1016/j.trsl.2019.07.013. Epub 2019 Aug 10.PMID: 31469974.

  36. Zou YC, Gao YP, Yin HD, Liu G. Serum miR-21expression correlates with radiographic progression butalso low bone mineral density in patients with ankylosingspondylitis: a cross-sectional study. Innate Immun. 2019Jul;25(5):314-321. doi: 10.1177/1753425919842932.Epub 2019 Apr 18. PMID: 30997863; PMCID:PMC6830902.

  37. Suarjana IN, Isbagio H, Soewondo P, Rachman IA,Sadikin M, Prihartono J et al. The Role of SerumExpression Levels of Microrna-21 on Bone MineralDensity in Hypostrogenic Postmenopausal Womenwith Osteoporosis: Study on Level of RANKL, OPG,TGFβ-1, Sclerostin, RANKL/OPG Ratio, and PhysicalActivity. Acta Med Indones. 2019 Jul;51(3):245-252.PMID: 31699948.

  38. Weng PW, Yadav VK, Pikatan NW, Fong IH, Lin IH,Yeh CT et al. Novel NFκB Inhibitor SC75741 MitigatesChondrocyte Degradation and Prevents ActivatedFibroblast Transformation by Modulating miR-21/GDF-5/SOX5 Signaling. Int J Mol Sci. 2021 Oct14;22(20):11082. doi: 10.3390/ijms222011082. PMID:34681754; PMCID: PMC8538686.

  39. La Sala L, Mrakic-Sposta S, Tagliabue E, Prattichizzo F,Micheloni S, Sangalli E et al. Circulating microRNA-21is an early predictor of ROS-mediated damage in subjectswith high risk of developing diabetes and in drug-naïveT2D. Cardiovasc Diabetol. 2019 Feb 25;18(1):18.doi: 10.1186/s12933-019-0824-2. PMID: 30803440;PMCID: PMC6388471.

  40. Huang C, Luo W, Wang Q, Ye Y, Fan J, Lin L et al. Humanmesenchymal stem cells promote ischemic repairmentand angiogenesis of diabetic foot through exosomemiRNA-21-5p. Stem Cell Res. 2021 Apr;52:102235.doi: 10.1016/j.scr.2021.102235. Epub 2021 Feb 11.PMID: 33601096.

  41. Chang WT, Huang TL, Chen ZC, Feng YH. TheExpression of MicroRNA-21 in Bone Marrow Fluid isan Indicator of Hematological Disorders and Mortality.Asian Pac J Cancer Prev. 2020 Oct 1;21(10):2817-2821. doi: 10.31557/APJCP.2020.21.10.2817. PMID:33112535; PMCID: PMC7798149.

  42. Mirza MAB, Guru SA, Abdullah SM, Rizvi A, Saxena A.microRNA-21 Expression as Prognostic and TherapeuticResponse Marker in Chronic Myeloid LeukaemiaPatients. Asian Pac J Cancer Prev. 2019 Aug 1;20(8):2379-2383. doi: 10.31557/APJCP.2019.20.8.2379. PMID:31450909; PMCID: PMC6852824.

  43. Moussa Agha D, Rouas R, Najar M, Bouhtit F, Fayyad-Kazan H, Lagneaux L et al. Impact of Bone MarrowmiR-21 Expression on Acute Myeloid Leukemia TLymphocyte Fragility and Dysfunction. Cells. 2020Sep 8;9(9):2053. doi: 10.3390/cells9092053. PMID:32911844; PMCID: PMC7563595.

  44. Zhan L, Pang Y, Jiang H, Zhang S, Jin H, Chen J et al.Butylphthalide Inhibits TLR4/NF-κB Pathwayby Upregulation of miR-21 to Have the NeuroprotectiveEffect. J Healthc Eng. 2022 Jan 7; 2022:4687349. doi:10.1155/2022/4687349. PMID: 35035839; PMCID:PMC8759846.

  45. Xiao G, Huang B, Guo M, Long C, Li P, Zhong Bet al. Long non-coding RNA BRCAT54 spongesmicroRNA-21 in vestibular schwannoma to suppresscell proliferation. Bioengineered. 2022 Feb;13(2):4301-4308. doi: 10.1080/21655979.2022.2031410. PMID:35137654; PMCID: PMC8973964.

  46. Xiong Y, Xiong Y, Zhang H, Zhao Y, Han K, Zhang J et al.hPMSCs-Derived Exosomal miRNA-21 Protects AgainstAging-Related Oxidative Damage of CD4+ T Cells by Targeting the PTEN/PI3K-Nrf2 Axis.Front Immunol. 2021 Nov 23; 12:780897. doi: 10.3389/fimmu.2021.780897. PMID: 34887868; PMCID:PMC8649962.

  47. Tangtanatakul P, Klinchanhom S, Sodsai P, Sutichet T,Promjeen C, Avihingsanon Y et al. Down-regulationof let-7a and miR-21 in urine exosomes from lupusnephritis patients during disease flare. Asian Pac J AllergyImmunol. 2019 Dec;37(4):189-197. doi: 10.12932/AP-130318-0280. PMID: 30118248.

  48. Zhang R, Wu L, Zhang HJ, Gao XJ, Pan XT, WangXR et al. Expression levels of plasma miRNA-21 andNT-proBNP in children with Kawasaki disease andtheir clinical significance. Eur Rev Med PharmacolSci. 2020 Dec;24(24):12757-12762. doi: 10.26355/eurrev_202012_24175. PMID: 33378024.

  49. Nuñez-Borque E, Fernandez-Bravo S, Rodriguez DelRio P, Alwashali EM, Lopez-Dominguez D, Gutierrez-Blazquez MD et al. Increased miR-21-3p and miR487b-3p serum levels during anaphylactic reaction infood allergic children. Pediatr Allergy Immunol. 2021Aug;32(6):1296-1306. doi: 10.1111/pai.13518. Epub2021 May 7. PMID: 33876465; PMCID: PMC8453890.

  50. Lu J, Liu D, Tan Y, Deng F, Li R. M1 Macrophageexosomes MiR-21a-5p aggravates inflammatory boweldisease through decreasing E-cadherin and subsequentILC2 activation. J Cell Mol Med. 2021 Mar;25(6):3041-3050. doi: 10.1111/jcmm.16348. Epub 2021 Feb 10.PMID: 33569850; PMCID: PMC7957199.

  51. Yildirim E, Ermis E, Allahverdiyev S, Ucar H, YavuzerS, Cengiz M. Circulating miR-21 levels in hypertensivepatients with asymptomatic organ damage. Medicine(Baltimore). 2019 Sep;98(39): e17297. doi: 10.1097/MD.0000000000017297. PMID: 31574853; PMCID:PMC6775376.

  52. Kara SP, Ozkan G, Yılmaz A, Bayrakçı N, Güzel S,Geyik E. MicroRNA 21 and microRNA 155 levelsin resistant hypertension, and their relationships withaldosterone. Ren Fail. 2021 Dec;43(1):676-683. doi:10.1080/0886022X.2021.1915800. PMID: 33888045;PMCID: PMC8078961.

  53. Barbu MG, Condrat CE, Thompson DC, Bugnar OL,Cretoiu D, Toader OD, Suciu N, Voinea SC. MicroRNAInvolvement in Signaling Pathways During ViralInfection. Front Cell Dev Biol. 2020 Mar 10;8:143. Doi:10.3389/fcell.2020.00143. PMID: 32211411; PMCID:PMC7075948

  54. He G, Ding J, Zhang Y, Cai M, Yang J, Cho WC etal. microRNA-21: a key modulator in oncogenic viralinfections. RNA Biol. 2021 May;18(5):809-817. doi:10.1080/15476286.2021.1880756. Epub 2021 Mar 22.PMID: 33499700; PMCID: PMC8078529.

  55. Pandey N, Rastogi M, Singh SK. Chandipura virusdysregulates the expression of hsa-miR-21-5p to activateNF-κB in human microglial cells. J Biomed Sci. 2021 Jul7;28(1):52. doi: 10.1186/s12929-021-00748-0. PMID:34233673; PMCID: PMC8265105.

  56. Shi J, Feng P, Gu T. MicroRNA-21-3p modulates FGF2 tofacilitate influenza A virus H5N1 replication by refrainingtype I interferon response. Biosci Rep. 2020 May29;40(5): BSR20200158. doi: 10.1042/BSR20200158.PMID: 32432671; PMCID: PMC7256676.

  57. Castro-Leyva V, Arenas-Huertero F, Espejel-NúñezA, Giono Cerezo S, Flores-Pliego A, Espino Y SosaS et al. miR-21 differentially regulates IL-1β and IL-10 expression in human decidual cells infected withstreptococcus B. Reprod Biol. 2022 Mar;22(1):100604.doi: 10.1016/j.repbio.2022.100604. Epub 2022 Jan 13.PMID: 35033900.

  58. Na L, Ding H, Xing E, Zhang Y, Gao J, Liu B et al. Thepredictive value of microRNA-21 for sepsis risk and itscorrelation with disease severity, systemic inflammation,and 28-day mortality in sepsis patients. J Clin Lab Anal.2020 Mar;34(3):e23103. doi: 10.1002/jcla.23103. Epub2019 Nov 28. PMID: 31778243; PMCID: PMC7083453

  59. Jazbutyte V, Thum T. MicroRNA-21: from cancerto cardiovascular disease. Curr Drug Targets. 2010Aug;11(8):926-35. doi: 10.2174/138945010791591403.PMID: 20415649.

  60. Fitzgerald JB, George J, Christenson LK. Non-codingRNA in Ovarian Development and Disease. Adv ExpMed Biol. 2016;886:79-93. doi: 10.1007/978-94-017-7417-8_5. PMID: 26659488; PMCID: PMC5535786.

  61. Ma R, Li X, Tewari N, Liu Y, Bhawal UK, Zeng X.microRNA-21 ameliorates the impairment of autophagyin palatal wound healing. J Physiol Pharmacol. 2020Dec;71(6). doi: 10.26402/jpp.2020.6.14. Epub 2021 Apr22. PMID: 33902001.

  62. Liu R, Du J, Zhou J, Zhong B, Ba L, Zhang J et al. ElevatedmicroRNA-21 Is a Brake of Inflammation Involved inthe Development of Nasal Polyps. Front Immunol. 2021Apr 15; 12:530488. doi: 10.3389/fimmu.2021.530488.PMID: 33936025; PMCID: PMC8082185.

  63. Shchurevska OD, Zhuk SI. Assessment of correlationbetween mirnas-21-3p and -210-3p expression inmaternal and umbilical cord plasma and fetal weight atbirth. Wiad Lek. 2021;74(2):236-240. PMID: 33813478.

  64. Hu L, Han D, Yu D, Ao D, Yang Z. Circulating BloodmiR-155 and miR-21 Promote the Development ofAcute Pancreatitis and Can Be Used to Assess the RiskStratification of Pancreatitis. J Healthc Eng. 2021 Dec14; 2021:2064162. doi: 10.1155/2021/2064162. PMID:34950438; PMCID: PMC8692001.




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