2023, Number 2
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Med Int Mex 2023; 39 (2)
Behind the scenes: ANCA-associated vasculitides and ACR/EULAR 2022 classification criteria
Mercado U
Language: Spanish
References: 9
Page: 370-376
PDF size: 182.09 Kb.
ABSTRACT
What we currently know as anti-neutrophil cytoplasmic antibody (ANCA)-associated
vasculitis had previously been recognized in 1923, 1937 and 1951 in autopsies and
later renamed microscopic polyangiitis, granulomatosis with polyangiitis (Wegener) and
eosinophilic granulomatosis with polyangiitis. In 1954, granulomatosis with polyangiitis
(Wegener) was reported for the first time in a clinical journal and in 1964 Alarcon-
Segovia included it in its classification. At first, the finding of ANCA in patients with
glomerulonephritis with extra-renal manifestations did not attract attention. Van der
Woude used them as a diagnostic and monitoring tool for patients with granulomatosis
with polyangiitis (Wegener). The Chapel-Hill nomenclature revised in 2012 subdivided
small-vessel vasculitides into 2 subtypes: immune complex vasculitis and ANCA-associated
vasculitis. In 2022, a group of experts endorsed by the ACR/EULAR developed
and validated the classification criteria for these 3 types of ANCA-associated vasculitis.
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Lyons PA, James E Peters JE, Federico Alberici F, Liley J,Coulson RMR, et al. Genome-wide association study ofeosinophilic granulomatosis with polyangiitis reveals genomicloci stratified by ANCA status. Nat Commun 2019;10: 5120. https://doi.org/10.1038/s41467-019-12515-9.
Almaani, Fussner LA, Brodsky S, Meara AS, Jayne D. ANCAassociatedvasculitis: An update. J Clin Med 2021; 10: 1-22.doi: 10.3390/jcm10071446.