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2022, Number 4

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Rev Med UAS 2022; 12 (4)

Structure, signaling and regulation of adiponectin in relation to insulin sensitivity and gestational diabetes: clinical and genetic findings

López-Quintero AE, Cotero-de la Torre II, Bravo-Villagra KM, Herrera-Salazar A, Picos-Cárdenas VJ, Morgan-Ortíz F, Trapero-Corona IM, Muñoz-Valle JF, López-Quintero A

Language: Spanish
References: 68
Page: 345-367
PDF size: 686.19 Kb.


ABSTRACT

Adipose tissue synthesizes and secretes a series of molecules implicated in various processes such as energy homeostasis, immunity, and inflammation. Adiponectin is involved in the control of homeostasis in insulin-sensitive tissues; it is mainly found in circulation as oligomers of different molecular weights that activate diverse signaling pathways. The role of adiponectin and its isoforms in the regulation of energy homeostasis and its possible use as a prognostic biomarker in insulin sensitivity, generate the need to know the impact of interventions that modify its circulating or expression levels. This knowledge is particularly important in the search for strat-egies to improve the metabolic status of subjects with altered metabolic conditions such as gestational diabetes. Therefore, the ob-jective of this review was to integrate knowledge to improve understanding of adiponectin regulation and its clinical application.


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