medigraphic.com
ISSN 0326-3428 (Print)
Órgano de difusión científica de la Asociación Nefrológica de Buenos Aires

2023, Number 1

<< Back Next >>

Rev Nefrol Dial Traspl 2023; 43 (1)

Results of Use of Ringer Solution and Preservation Solution as Kidney Washing Solution in Living Donor Renal Transplantation

Firat N, Akin E, Dheir H, Celebi F, Burak KM, Altintoprak F

Language: English
References: 25
Page: 38-45
PDF size: 128.92 Kb.


ABSTRACT

Background and Aims: Preservation solutions used as kidney washing solutions in transplantation are necessary for the longer preservation of the kidney. the study aims to compare dierent kidney-washing solutions used in living renal transplantation. Methods and Results: Forty- nine patients who underwent renal transplantation from live donors were included in the retrospective study. the Ringer’s solution Lushed the renal graft in 37 patients (Group 1), and the preservation solution was in 12 patients (Group 2). Group 1, and Group 2 patients were included in the study. there were 22 (59.5%) males in Group 1 and 9 (75%) males in Group 2. Twenty-seven (73%) patients using Ringer’s and 7 (58.3%) patients on preservation solution had comorbidities. there was no significant diference between Group 1 and Group 2 in warm ischemia time, cold ischemia time, and HLA mismatch levels (p› 0.05). the preoperative creatinine value was significantly higher in the preservation solution group (p = 0.003). there was no significant diference between the two groups in values of creatinine levels on the postoperative (p› 0.05). Conclusion: In living renal transplantation, an inexpensive Ringer’s solution, may be used instead of the expensive preservation solution to wash the graft.


REFERENCES

  1. Axelrod DA, Schnitzler MA, Xiao H, Irish W, Tuttle-Newhall E, Chang S-H, et al. An economic assessmentof contemporary kidney transplant practice. American Journal of Transplantation. 2018;18: 1168–1176. doi:https://doi.org/10.1111/ajt.14702

  2. Firat N, Dheir H, Akin E, Sipahi S, Altintoprak F,Çelebi F, et al. Canlı Donörden Böbrek Nakli: IlkDeneyimlerimiz. Online Türk Saglık Bilimleri Dergisi.2020;5: 356–363. doi:10.26453/otjhs.705092

  3. Ferede AA, Walsh AL, Davis NF, Smyth G, MohanP, Power R, et al. Warm Ischemia Time at VascularAnastomosis is an Independent Predictor for DelayedGraft Function in Kidney Transplant Recipients.Exp Clin Transplant. 2020;18: 13–18. doi:10.6002/ect.2018.0377

  4. Belzer FO, Southard JH. Principles of solid-organpreservation by cold storage. Transplantation. 1988;45:673–676. doi:10.1097/00007890-198804000-00001

  5. Harvey RB. Eect of temperature on function ofisolated dog kidney. Am J Physiol. 1959;197: 181–186. doi:10.1152/ajplegacy.1959.197.1.181

  6. Prasad GS, Ninan CN, Devasia A, Gnanaraj L, KekreNS, Gopalakrishnan G. Is Euro-Collins better thanringer lactate in live related donor renal transplantation?Indian J Urol. 2007;23: 265–269. doi:10.4103/0970-1591.33722

  7. Yalın A, Keskinöz EN, Kızaran A. Organ Korunması.2011 [cited 5 Dec 2020]. Available: http://openaccess.acibadem.edu.tr:8080/xmlui/handle/11443/164

  8. 8) Collins GM, Bravo-Shugarman M, Terasaki PI. Kidneypreservation for transportation. Initial perfusion and30 hours’ ice storage. Lancet. 1969;2: 1219–1222.doi:10.1016/s0140-6736(69)90753-3

  9. De Boer J, De Meester J, Smits JM, GroenewoudAF, Bok A, van der Velde O, et al. Eurotransplantrandomized multicenter kidney graft preservationstudy comparing HTK with UW and euro-Collins. Transpl Int. 1999;12: 447–453. doi:10.1007/s001470050256

  10. Martínez J, Bächler JP, Moisan F, Torres J, DuarteI, Pérez RM, et al. [Outcomes using two preservationsolutions (UW/HTK) in liver transplantation frombrain death donors]. Rev Med Chil. 2014;142: 1229–1237. doi:10.4067/S0034-98872014001000001

  11. Maathuis M-HJ, Leuvenink HGD, Ploeg RJ.Perspectives in organ preservation. Transplantation.2007;83: 1289–1298. doi:10.1097/01.tp.0000265586.66475.cc

  12. Nashan B, Abbud-Filho M, Citterio F. Prediction,prevention, and management of delayed graft function:where are we now? Clin Transplant. 2016;30: 1198–1208. doi:10.1111/ctr.12832

  13. Weissenbacher A, Voyce D, Ceresa CDL, SoaresMF, Roberts IS, Hunter JP, et al. Urine RecirculationImproves Hemodynamics and Enhances Function inNormothermic Kidney Perfusion. Transplant Direct.2020;6. doi:10.1097/TXD.0000000000000985

  14. Legeai C, Durand L, Savoye E, Macher M-A, BastienO. Eect of preservation solutions for static cold storageon kidney transplantation outcomes: A NationalRegistry Study. American Journal of Transplantation.2020;20: 3426–3442. doi: https://doi.org/10.1111/ajt.15995

  15. O’Callaghan JM, Knight SR, Morgan RD, MorrisPJ. Preservation Solutions for Static Cold Storageof Kidney Allografts: A Systematic Review andMeta-Analysis. American Journal of Transplantation.2012;12: 896–906. doi: https://doi.org/10.1111/j.1600-6143.2011.03908.x

  16. Beule JD, Fieuws S, Monbaliu D, Naesens M,SainzBarriga M, Sprangers B, et al. the efect ofIGL-1 preservation solution on outcome after kidneytransplantation: A retrospective single-center analysis.American Journal of Transplantation. n/a. doi: https://doi.org/10.1111/ajt.16302

  17. Nunes P, Mota A, Figueiredo A, Macário F, Rolo F,Dias V, et al. Ecacy of renal preservation: comparativestudy of Celsior and University of Wisconsin solutions.Transplant Proc. 2007;39: 2478–2479. doi: 10.1016/j.transproceed.2007.07.024

  18. Darius T, Massaad L, Meyer M de, Buemi A,Kanaan N, Devresse A, et al. Comparison of IGL-1Versus UW Ex Vivo Back Table Flush on Early GraftFunction after Living Donor Kidney Transplantation:Retrospective Single Center Analysis. Transplantation.2018;102. doi:10.1097/01. tp.0000543081.06142.75

  19. Bugge JF, Hartmann A, Osnes S, Bentdal O,Stenstrøm J. Immediate and early renal functionafter living donor transplantation. Nephrology DialysisTransplantation. 1999;14: 389–393. doi:10.1093/ndt/14.2.389

  20. Tan HP, Vyas D, Basu A, Randhawa P, Shah N,Donaldson J, et al. Cold Heparinized LactatedRingers with Procaine (HeLP) Preservation Fluidin 266 Living Donor Kidney Transplantations.Transplantation. 2007;83: 1134. doi:10.1097/01.tp.0000260408.47857.61

  21. Ozturk SA, Yuksel Y, Erbis H, Aliosmanoglu I,Sarier M, Yayar O, et al. Laparoscopic Live DonorNephrectomy: Experience of High-Volume Centerwith 2,477 Cases. UIN. 2021;105: 100–107. doi:10.1159/000511377

  22. Reyna-Sepúlveda F, Ponce-Escobedo A, Guevara-Charles A, Escobedo-Villarreal M, Pérez-Rodríguez E,Muñoz-Maldonado G, et al. Outcomes and SurgicalComplications in Kidney Transplantation. Int J OrganTransplant Med. 2017;8: 78–84.

  23. Axelrod D, Lentine KL, Schnitzler MA, Luo X,Xiao H, Orandi BJ, et al. the Incremental Cost ofIncompatible Living Donor Kidney Transplantation:A National Cohort Analysis. American Journal ofTransplantation. 2017;17: 3123–3130. doi: https://doi.org/10.1111/ajt.14392

  24. Aydin C, Berber I, Altaca G, Yigit B, Titiz I. the outcome of kidney transplants with multiple renalarteries. BMC Surgery. 2004;4: 4. doi:10.1186/1471-2482-4-4

  25. Mannon RB. Delayed Graft Function: the AKI ofKidney Transplantation. Nephron. 2018;140: 94–98.doi:10.1159/000491558




2020     |     www.medigraphic.com