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2022, Number 2

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Rev Hematol Mex 2022; 23 (2)

Myeloid sarcoma and its extramedullary manifestations

Padilla-Armas JL, Vacio-Marrufo PA, Luna-Sada AL, Flores-Guerrero S, Romero-Aguilar F, López-Giacoman S, Chávez LF, Robles-Jaime JA, Manríquez-Montellano F, Valdez-Bonilla A, Casas-Robles ML, Bañuelos-Ibáñez RM, Rodríguez-Durán CO, Lara-Salazar FM

Language: Spanish
References: 38
Page: 120-127
PDF size: 371.27 Kb.


ABSTRACT

Background: Myeloid sarcoma could be the initial manifestation of acute myeloid leukemia. This neoplasm is characterized by extramedullary dissemination of mature myeloid cells and immature myeloid cells as well. To diagnose myeloid sarcoma an opacification of local tissue should be present. There is a male predominance, with a male:female ratio 1.2:1, it could be seen at any age and every part of the body could be affected by the disease. The most commonly affected sites are lymphatic ganglia, skin, soft tissue, bones, testicles, gastrointestinal tract and peritoneum.
Clinical case: A 40-year-old patient diagnosed with myeloid sarcoma during the approach of a tumor at T11-T12 that on bone marrow biopsy were observed normal cellularity and the immunohistochemical reports revealed MPO+, CD-43+ and CD117+, with a proliferation index of 60%.
Conclusions: Myeloid sarcoma affects 2.5-9.1% of patients with acute myeloid leukemia. The exact mechanism of extramedullary damage is not understood completely.


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