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2022, Número 2

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Rev Hematol Mex 2022; 23 (2)


Sarcoma mieloide y sus manifestaciones extramedulares

Padilla-Armas JL, Vacio-Marrufo PA, Luna-Sada AL, Flores-Guerrero S, Romero-Aguilar F, López-Giacoman S, Chávez LF, Robles-Jaime JA, Manríquez-Montellano F, Valdez-Bonilla A, Casas-Robles ML, Bañuelos-Ibáñez RM, Rodríguez-Durán CO, Lara-Salazar FM

Idioma: Español
Referencias bibliográficas: 38
Paginas: 120-127
Archivo PDF: 371.27 Kb.


RESUMEN

Antecedentes: El sarcoma mieloide puede ser la primera manifestación de la leucemia mieloide aguda. El tumor consiste en blastos mieloides maduros o inmaduros presentes en un sitio anatómico más allá del hueso. Para diagnosticar el sarcoma mieloide debe estar presente una masa tumoral que provoque borramiento del tejido local. Tiene predominio masculino con una relación hombre:mujer de 1.2:1, puede aparecer a cualquier edad y en cualquier parte del cuerpo. Los sitios más comúnmente afectados son los ganglios linfáticos, la piel, los tejidos blandos, los huesos, los testículos, el tubo gastrointestinal y el peritoneo.
Caso clínico: Paciente masculino de 40 años de edad que fue diagnosticado con sarcoma mieloide durante el abordaje de una tumoración a nivel de T11-T12, en quien durante el aspirado de biopsia de médula ósea se observó celularidad normal, con reporte de inmunohistoquímica: MPO+, CD-43+ y CD-117+, con índice de proliferación del 60%.
Conclusiones: El sarcoma mieloide afecta al 2.5-9.1% de los pacientes con leucemia mieloide aguda. El mecanismo exacto de la afectación extramedular no se comprende por completo.


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