medigraphic.com
Colegio de Medicina Interna de México.

2022, Number 6

<< Back Next >>

Med Int Mex 2022; 38 (6)

Relationship of fine needle aspiration biopsy with histopathological result in thyroid nodules

Fierros-Michel JF, López-López RM, Valencia-Méndez CV, Ornelas-Aguirre JM

Language: Spanish
References: 21
Page: 1170-1177
PDF size: 200.81 Kb.


ABSTRACT

Objective: To evaluate the concordance between the fine needle aspiration biopsy cytology and post-thyroidectomy histopathological report in patients with TIRADS 3, 4 and 5 thyroid nodules in a third level hospital.
Materials and Methods: Observational, analytical, cross-sectional and retrospective study that consisted of reviewing the records of patients with thyroid nodules in whom fine needle aspiration biopsy had been performed and who required thyroidectomy, during the period from June 2017 to June 2019.
Results: Twenty-six cases were analyzed, with 10 of them positive for malignancy; all were reported as papillary thyroid carcinoma. The concordance between Bethesda VI and the histopathological result of thyroidectomy was 50% (p = 0.72) while for Bethesda V there was a correlation of malignancy of 83.3% (p = 0.01) using the χ2 test; for TIRADS categories 3, 4 and 5 a correlation with respect to malignancy of 60, 25 and 44.4%, respectively was obtained.
Conclusions: The thyroid ultrasound findings by TIRADS and fine needle aspiration biopsy reported in Bethesda category can help the physician to estimate the risk of malignancy in patients with thyroid nodules.


REFERENCES

  1. Haugen BR, Alexander EK, Bible KC, Doherty GM, MandelSJ, Nikiforov YE, et al. 2015 American Thyroid AssociationManagement Guidelines for Adult Patients with ThyroidNodules and Differentiated Thyroid Cancer: The AmericanThyroid Association Guidelines Task Force on ThyroidNodules and Differentiated Thyroid Cancer. Thyroid 2016; 26 (1): 1-133. DOI: 10.1089/thy.2015.0020.

  2. Durante C, Costante G, Lucisano G, Bruno R, MeringoloD, Paciaroni A, et al. The natural history of benign thyroidnodules. JAMA 2015; 313 (9): 926-35. doi:10.1001/jama.2015.0956.

  3. Popoveniuc G, Jonklaas J. Thyroid nodules. Med. Clin. NorthAm 2012; 96 (2): 329-49. doi:10.1016/j.mcna.2012.02.002.

  4. Pemayun TG. Current diagnosis and management ofthyroid nodules. Acta Med Indones 2016; 48 (3): 247-257.

  5. Burman KD, Wartofsky L. Clinical practice. Thyroid nodules.N Engl J Med 2015; 373 (24): 2347-56. DOI: 10.1056/NEJMcp1415786.

  6. Langer JE. Sonography of the thyroid. Radiol Clin NorthAm 2019; 57 (3): 469-483. DOI: 10.1016/j.rcl.2019.01.001.

  7. Symonds CJ, Seal P, Ghaznavi S, Cheung WY, PaschkeR. Thyroid nodule ultrasound reports in routine clinicalpractice provide insufficient information to estimate riskof malignancy. Endocrine 2018; 61 (2): 303-307. DOI:10.1007/s12020-018-1634-0.

  8. Zhang F, Oluwo O, Castillo FB, Gangula P, Castillo M, FaragF, et al. Thyroid nodule location on ultrasonography as apredictor of malignancy. Endocr Pract 2019; 25 (2): 131-137. DOI: 10.4158/EP-2018-0361.

  9. Ramundo V, Lamartina L, Falcone R, Ciotti L, Lomonaco C,Biffoni M, et al. Is thyroid nodule location associated withmalignancy risk? Ultrasonography 2019; 38 (3): 231-235.doi.org/10.14366/usg.18050.

  10. Ha EJ, Baek JH, Na DG. Risk stratification of thyroidnodules on ultrasonography: Current status and perspectives.Thyroid 2017; 27 (12): 1463-68. DOI: 10.1089/thy.2016.0654.

  11. Grani G, Lamartina L, Ascoli V, Bosco D, Biffoni M, GiacomelliL, et al. Reducing the number of unnecessary thyroidbiopsies while improving diagnostic accuracy: Toward the“right” TIRADS. J Clin Endocrinol Metab 2019; 104 (1): 95-102. doi: 10.1210/jc.2018-01674.

  12. Hoang JK, Middleton WD, Farjat AE, Langer JE, ReadingCC, Teefey SA, et al. Reduction in thyroid nodule biopsiesand improved accuracy with American College ofRadiology Thyroid Imaging and Reporting Data System.Radiology 2018; 287 (1): 185-93. doi.org/10.1148/radiol.2018172572.

  13. Al Dawish MA, Alwin RA, Thabet MA, Braham R. Thyroidnodule management: Thyroid-stimulating hormone,ultrasound, and cytological classification system forpredicting malignancy. Cancer Inform 2018; 19 (17).doi/10.1177/1176935118765132.

  14. Melany M, Chen S. Thyroid cancer: Ultrasound imaging andfine-needle aspiration biopsy. Endocrinol Metab Clin NorthAm 2017; 46 (3): 691-711. doi: 10.1016/j.ecl.2017.04.011.

  15. Abele JS. Private practice outpatient fine needle aspirationclinic: A 2018 update. Cancer Cytopathol 2018; 126 (11):902-923. doi: 10.1002/cncy.22041.

  16. Abi-Raad R, Prasad M, Baldassari R, Schofield K, CallenderGG, Chhieng D, et al. The value of negative diagnosis inthyroid fine-needle aspiration: a retrospective study withhistologic follow-up. Endocr Pathol 2018; 29 (3): 269-275.doi: 10.1007/s12022-018-9536-5.

  17. Cibas ES, Ali SZ. The 2017 Bethesda System for ReportingThyroid Cytopathology. Thyroid 2017; 27 (11): 1341-1346.DOI: 10.1089/thy.2017.0500.

  18. Seshadri KG. A pragmatic approach to the indeterminatethyroid nodule. Indian J Endocr Metab 2017; 21 (5): 751-7.doi: 10.4103/ijem.IJEM_143_17.

  19. Gharib H, Papini E, Garber JR, Duick DS, Harrell RM,Hegedüs L, et al. American Association of Clinical Endocrinologists,American College of Endocrinology, andAssociazione Medici Endocrinologi medical guidelinesfor clinical practice for the diagnosis and management ofthyroid nodules—2016 update. Endocr Pract 2016; 22 (5):622-639. doi: 10.4158/EP161208.GL.

  20. Yeung MJ, Serpell JW. Management of the solitary thyroidnodule. Oncologist 2008; 13 (2): 105-12. doi: 10.1634/theoncologist.2007-0212.

  21. Maxwell C, Sipos JA. Clinical diagnostic evaluation ofthyroid nodules. Endocrinol Metab Clin North Am 2019;48 (1): 61-84. doi: 10.1016/j.ecl.2018.11.001.




2020     |     www.medigraphic.com