2022, Number 3
<< Back Next >>
Rev Latin Infect Pediatr 2022; 35 (3)
Toxic shock syndrome: from suspicion to fulfillment of diagnostic criteria
Moreno PL, Argumánez GD, Santana RV, López LR, Baquero-Artigao F, Vivas-la CMC
Language: Spanish
References: 25
Page: 113-119
PDF size: 226.35 Kb.
ABSTRACT
Introduction: Toxic shock syndrome (TSS) is an acute and severe disease, that is uncommon amongst children. It is characterized by fever, rash, hypotension, and multisystem organ failure. It is mainly caused by Staphylococcus aureus and Streptococcus pyogenes.
Objective: Analyse if the children with initial suspicion of TSS meet the clinical and analytical diagnostic criteria.
Material and methods: Retrospective study of patients under 16 years of age with TSS treated between 2010 and 2017 in a tertiary paediatric hospital. We revised their clinical history and classified the cases according to their aetiology and fulfilment of CDC criteria.
Results: Twenty cases were diagnosed as TSS. The most common symptoms were fever and rash. Multisystem organ failure was most frequently mucous and gastrointestinal in the staphylococcal cases and hematologic in the streptococcal ones. Intensive care support was necessary for 60% of the patients. Thirteen of the twenty patients met the CDC criteria (10 staphylococcal and three streptococcal).
Conclusion: From the children with initial suspicion of TSS, only 65% met the CDC criteria. One third of the patients were diagnosed and treated as TSS without fulfilling said criteria, possibly because early management of the disease can stop its progression.
REFERENCES
Spaulding AR, Salgado-Pabón W, Kohler PL, Horswill AR, Leung DY, Schlievert PM. staphylococcal and streptococcal superantigen exotoxins. Clin Microbiol Rev. 2013; 26 (3): 422-447.
Schlievert PM. Role of superantigens in human disease. J Infect Dis. 1993; 167 (5): 997-1002.
Kum WW, Laupland KB, Chow AW. Defining a novel domain of staphylococcal toxic shock syndrome toxin-1 critical for major histocompatibility complex class II binding, superantigenic activity, and lethality. Can J Microbiol. 2000; 46 (2): 171-179.
Christensson B, Hedstrom SA. Serological response to toxic shock syndrome toxin in Staphylococcus aureus infected patients and healthy controls. Acta Pathol Microbiol Immunol Scand B. 1985; 93 (2): 87-90.
Sharma H, Smith D, Turner CE, Game L, Pichon B, Hope R et al. Clinical and molecular epidemiology of staphylococcal toxic shock syndrome in the United Kingdom. Emerg Infect Dis. 2018; 24 (2): 258-266.
Hajjeh RA, Reingold A, Weil A, Shutt K, Schuchat A, Perkins BA. Toxic shock syndrome in the United States: surveillance update, 1979 1996. Emerg Infect Dis. 1999; 5 (6): 807-810.
Todd J, Fishaut M, Kapral F, Welch T. Toxic-shock syndrome associated with phage-group 1-staphilococci. Lancet. 1978; 2 (8100): 1116-1118.
Holt P. Tampon-associated toxic shock syndrome. Br Med J. 1980; 281 (6251): 1321-1322.
Centers for Disease Control (CDC). Reduced incidence of menstrual toxic-shock syndrome-United States, 1980-1990. MMWR Morb Mortal Wkly Rep. 1990; 39 (25): 421-423.
Broome CV. Epidemiology of toxic shock syndrome in the United States: overview. Rev Infect Dis. 1989; 11 (1): S14-21.
Reingold AL, Broome CV, Gaventa S, Hightower AW. Risk factors for menstrual toxic shock syndrome: results of a multistate case-control study. Rev Infect Dis. 1989; 11 (1): S35-41.
Gaventa S, Reingold AL, Hightower AW, Broome CV, Schwartz B, Hoppe C et al. Active surveillance for toxic shock syndrome in the United States, 1986. Rev Infect Dis. 1989; 11 (1): S28-34.
Bartlett P, Reingold AL, Graham DR, Dan BB, Selinger DS, Tank GW et al. Toxic shock syndrome associated with surgical wound infections. JAMA. 1982; 247 (10): 1448-1450.
Dann EJ, Weinberger M, Gillis S, Parsonnet J, Shapiro M, Moses AE. Bacterial laryngotracheitis associated with toxic shock syndrome in an adult. Clin Infect Dis. 1994; 18 (3): 437-439.
Paterson MP, Hoffman EB, Roux P. Severe disseminated staphylococcal disease associated with osteitis and septic arthritis. J Bone Joint Surg Br. 1990; 72 (1): 94-97.
Reingold AL, Hargrett NT, Dan BB, Shands KN, Strickland BY, Broome CV. Nonmenstrual toxic shock syndrome: a review of 130 cases. Ann Intern Med. 1982; 96 (6 Pt 2): 871-874.
Ekelund K, Skinhoj P, Madsen J, Konradsen HB. Reemergence of emm1 and a changed superantigen profile for group A streptococci causing invasive infections: results from a nationwide study. J Clin Microbiol. 2005; 43 (4): 1789-1796.
Svensson N, Oberg S, Henriques B, Holm S, Kallenius G, Romanus V et al. Invasive group A streptococcal infections in Sweden in 1994 and 1995: epidemiology and clinical spectrum. Scand J Infect Dis. 2000; 32 (6): 609-614.
Wharton M, Chorba TL, Vogt RL, Morse DL, Buehler JW. Centers for Disease Control. Case definitions for public health surveillance. MMWR Recomm Rep. 1990; 39: 38-39.
Butragueño LL, García MM, Barredo VE, Alcaraz RAJ. Síndrome de shock tóxico en una unidad de cuidados intensivos pediátricos en los últimos 15 años. An Pediatr (Barc). 2017; 87 (2): 111-113.
Costa Orvay JA, Caritg Bosch J, Morillo Palomo A, Noguera Julián T, Esteban Torne E, Palomeque Rico A. Síndrome de shock tóxico: experiencia en una UCIP. An Pediatr (Barc). 2007; 66 (6): 566-572.
Chen KYH, Cheung M, Burgner DP, Curtis N. Toxic shock syndrome in Australian children. Arch Dis Child. 2016 ;101 (8): 736-740.
Adalat S, Dawson T, Hackett SJ, Clark JE. Toxic shock syndrome surveillance in UK children. Arch Dis Child. 2014; 99 (12): 1078-1082.
Davis JP, Chesney PJ, Wand PJ, La Venture. Toxic-shock syndrome: Epidemiologic features, recurrence, risk factor and prevention. N Engl J Med. 1980; 303 (25): 1429-1435.
Andrews MM, Parent EM, Barry M, Parsonnet J. Recurrent nonmenstrual toxic shock syndrome: Clinical manifestations, diagnosis, and treatment. Clin Infect Dis. 2001; 32 (10): 1470-1479.