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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2022, Number 3

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Rev Biomed 2022; 33 (3)

Human papillomavirus 13 L1 gene polimorphism: first report

Cetina-Cetz IR, Conde-Ferráez L, Gómez-Carballo J, Ayora-Talavera G, González-Losa MR

Language: English
References: 37
Page: 96-104
PDF size: 1281.03 Kb.


ABSTRACT

Introduction. Human papillomavirus 13 (HPV-13) belonging to Alphapapillomavirus-10 species, is an oral mucosotropic virus phylogenetically related to other human papillomavirus (6, 11, 44, 55 and 74). It causes Multifocal Epithelial Hyperplasia, an uncommon benign oral disease reported mainly amongst ethnic groups from America.
Objective. To describe the genetic variability of the HPV-13 L1 gene.
Material and Methods. A retrospective study including 50 oral samples from patients with Multifocal Epithelial Hyperplasia, and 25 samples from asymptomatic carriers of HPV-13, all subjects living in Mayan area of Mexico. A fragment 240 bp corresponding to the HPV 13L1 gene, which encodes the major capsid protein was amplified, sequenced, and compared with the only two reference sequences of HPV-13 available. A phylogenetic tree was constructed using PAUP* software.
Results. Eight single nucleotide polymorphisms were identified including three synonymous polymorphism and five non-synonymous. According to the phylogenetic tree, the variants were grouped in two branches.
Conclusion. This is the first report for the presence of genetic polymorphisms of HPV-13. These results are relevant for future research aiming to identify lineages and sub lineages. Our in-silico analysis suggests that the amino acid changes would be involving structures directly related to antigen recognition, which requires further investigations.


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