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ISSN 2683-1678 (Print)
Órgano Oficial de la Sociedad
Latinoamericana de lnfectología Pediátrica.
Órgano de la Asociación Mexicana de
Infectología Pediátrica, A.C.
Órgano difusor de la Sociedad Española
de lnfectología

2022, Number 2

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Rev Latin Infect Pediatr 2022; 35 (2)

Human herpesvirus 6 (HHV-6) meningoencephalitis in a pediatric patient: case report and review of the literature

Martínez AMV, Aguilar GNE

Language: Spanish
References: 27
Page: 74-80
PDF size: 252.98 Kb.


ABSTRACT

Nine-month-old infant, previously healthy, from Mexico City, who presented with clinical of eight days of evolution receiving various symptomatic treatments on an outpatient basis, persisting with high-grade fever (39.0 oC) and presenting status epilepticus 24 hours prior admission to our institution, upon arrival at the physical examination, the patient was drowsy, hyporeactive with neck stiffness and pain on movement. After evaluating him, a diagnosis of meningoencephalitis was made, starting empirical antibiotic and steroid treatment; laboratory studies were performed, reporting 637 copies/ml of human herpes virus type 6 (HHV-6) in cerebrospinal fluid, antibiotic therapy was suspended, and ganciclovir was started for 14 days; patient is discharged in good general condition. Human herpesvirus type 6 (HHV-6) is a beta herpesvirus isolated for the first time in cerebrospinal fluid in 1990; it causes a wide range of clinical manifestations from its most common presentation such as roseola (25-30%) to neurological manifestations such as meningoencephalitis, which in 2.2% of cases occur in previously healthy children. Its diagnosis remains a challenge since careful exclusion of other etiologies is required; however, once the diagnosis is confirmed, it is imperative to start antiviral treatment in a timely manner to prevent neurological sequelae and even death.


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