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2022, Number Esp

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Sal Jal 2022; 9 (Esp)

Mastitis subclínica y subaguda: patologías frecuentemente subdiagnosticadas y de serias consecuencias

Contreras-Garduño KA, Colmenares-Castaño M, Cortina-Cortés M, Esquivel-Salinas IA, Gallegos-Velasco LS

Language: Spanish
References: 62
Page: 52-60
PDF size: 324.75 Kb.


ABSTRACT

Subclinic and subacute mastitis are less known diagnosis, and not frequently described for lactating women, specially in comparison to cows as it poses risks to the dairy industry. Sofar, there is no standardized criteria to define both diagnosis. What is evident, is that the development of a subclinical or subacute mastitis is quite different from an acute or purulent one. Pain while breastfeeding, sore nipples and low milk supply may be symptoms of subacute or subclinical mastitis. It has been described that human milk is not a sterile fluid, and dysbiosis can happen as a consequence of some risk factors. Women’s diet and body fat, health condition, use of drugs like antibiotics, type of birth, genetics, and birth place are identified as some conditions that can predispose an inflammatory process of the mammary gland. The purpose of this paper is to analyze what are the diagnosis criteria of subacute and subclinic mastitis. Further studies are needed to define the diagnosis criteria, and therapeutic interventions for both conditions. Subclinic and subacute mastitis are probably common causes of early weaning in lactating women.


REFERENCES

  1. Kvist LJ. Toward a clarifi cation of the concept of mastitis as usedin empirical studies of breast infl ammation during lactation. JHum Lact. 2010 Feb;26(1):53-9. doi: 10.1177/0890334409349806.PMID: 19910519.

  2. Amir LH; Academy of Breastfeeding Medicine ProtocolCommittee. ABM clinical protocol #4: Mastitis, revised March2014. Breastfeed Med. 2014 Jun;9(5):239-43. doi: 10.1089/bfm.2014.9984. PMID: 24911394; PMCID: PMC4048576.

  3. Douglas P. Re-thinking benign infl ammation of the lactating breast:A mechanobiological model. Womens Health (Lond). 2022 Jan-Dec;18:17455065221075907. doi: 10.1177/17455065221075907.PMID: 35156466; PMCID: PMC8848036.

  4. Shamah-Levy T, Vielma-Orozco E, Heredia-Hernández O,Romero-Martínez M, Mojica-Cuevas J, Cuevas-Nasu L, Santaella-Castell JA, Rivera-Dommarco J. Encuesta Nacional de Salud yNutrición 2018-19: Resultados Nacionales. Cuernavaca, México:Instituto Nacional de Salud Pública, 2020.

  5. Guiterrrez JP, Rivera-Donmarco J, Shamah-Levy T, Villapando-Hernández S, Franco A, Cuevas-Nasu L, et al. Encuesta Nacionalde Salud y Nutrición 2012. Resultados Nacionales. Cuernavaca,México: Instituto Nacional de Salud Pública (MX), 2012.

  6. Delgado S, Arroyo R, Jiménez E, Fernández L, RodríguezJM. Mastitis infecciosas durante la lactancia: un problemainfravalorado (I). Acta Pediatr Esp. 2009; 67: 77-84.

  7. World Health Organization (2000). Mastitis: Causes andmanagement. Geneva, Switzerland: WHO.

  8. Osejo Rodríguez M del S, Maya Cancino A, Brenes MeseguerN. Actualización de la clasifi cación y manejo de mastitis. Rev.méd.sinerg. [Internet]. 1 de junio de 2020 [citado 13 de junio de2021];5(6):e510. Disponible en: https://revistamedicasinergia.com/index.php/rms/article/view/510

  9. Wilson E, Woodd SL, Benova L. Incidence of and Risk Factorsfor Lactational Mastitis: A Systematic Review. J Hum Lact. 2020Nov;36(4):673-686. doi: 10.1177/0890334420907898. Epub 2020Apr 14. PMID: 32286139; PMCID: PMC7672676.

  10. Lee IW, Kang L, Hsu HP, Kuo PL, Chang CM. Puerperalmastitis requiring hospitalization during a nine-year period.Am J Obstet Gynecol. 2010 Oct;203(4):332.e1-6. doi: 10.1016/j.ajog.2010.05.012. PMID: 20599181.

  11. Yu JH, Kim MJ, Cho H, Liu HJ, Han SJ, Ahn TG. Breast diseasesduring pregnancy and lactation. Obstet Gynecol Sci. 2013May;56(3):143-59. doi: 10.5468/ogs.2013.56.3.143. Epub 2013May 16. PMID: 24327995; PMCID: PMC3784111.

  12. Hucker GJ. Incidence of Sub-Clinical Mastitis. Am J Public HealthNations Health. 1932 Jul;22(7):710-4. doi: 10.2105/ajph.22.7.710.PMID: 18013539; PMCID: PMC1556922.

  13. Filteau SM, Lietz G, Mulokozi G, Bilotta S, Henry CJ, TomkinsAM. Milk cytokines and subclinical breast infl ammation inTanzanian women: eff ects of dietary red palm oil or sunfl oweroil supplementation. Immunology. 1999 Aug;97(4):595-600. doi:10.1046/j.1365-2567.1999.00834.x. PMID: 10457212; PMCID:PMC2326873.

  14. Willumsen JF, Filteau SM, Coutsoudis A, Uebel KE, Newell ML,Tomkins AM. Subclinical mastitis as a risk factor for motherinfantHIV transmission. Adv Exp Med Biol. 2000;478:211-23.doi: 10.1007/0-306-46830-1_19. PMID: 11065074.

  15. Arsenault JE, Aboud S, Manji KP, Fawzi WW, Villamor E. Vitaminsupplementation increases risk of subclinical mastitis in HIVinfectedwomen. J Nutr. 2010 Oct;140(10):1788-92. doi: 10.3945/jn.110.122713. Epub 2010 Aug 25. PMID: 20739447; PMCID:PMC2937574.

  16. Kantarci S, Koulinska IN, Aboud S, Fawzi WW, Villamor E.Subclinical mastitis, cell-associated HIV-1 shedding in breastmilk, and breast-feeding transmission of HIV-1. J AcquirImmune Defi c Syndr. 2007 Dec 15;46(5):651-4. doi: 10.1097/QAI.0b013e31815b2db2. PMID: 18043320.

  17. Gomo E, Filteau S, Andrew M. Tomkins, Patricia Ndhlovu, KimFleischer Michaelsen, Henrik Friiss. Subclinical mastitis amongHIV-infected and uninfected Zimbabwean women participatingin a multimicronutrient supplementation trial, Transactions ofTh e Royal Society of Tropical Medicine and Hygiene, Volume97, Issue 2, March-April 2003, Pages 212–216, https://doi.org/10.1016/S0035-9203(03)90124-6

  18. Nussenblatt V, Lema V, Kumwenda N, Broadhead R, Neville MC,Taha TE, Semba RD. Epidemiology and microbiology of subclinicalmastitis among HIV-infected women in Malawi. Int J STD AIDS.2005 Mar;16(3):227-32. doi: 10.1258/0956462053420248. PMID:15829023

  19. Lunney KM, Iliff P, Mutasa K, Ntozini R, Magder LS, MoultonLH, Humphrey JH. Associations between breast milk viral load,mastitis, exclusive breast-feeding, and postnatal transmission ofHIV. Clin Infect Dis. 2010 Mar 1;50(5):762-9. doi: 10.1086/650535.PMID: 20121424.

  20. Nussenblatt V, Kumwenda N, Lema V, Quinn T, Neville MC,Broadhead R, Taha TE, Semba RD. Eff ect of antibiotic treatmentof subclinical mastitis on human immunodefi ciency virus type 1RNA in human milk. J Trop Pediatr. 2006 Oct;52(5):311-5. doi:10.1093/tropej/fml011. Epub 2006 Apr 4. PMID: 16595526.

  21. Kasonka L, Makasa M, Marshall T, Chisenga M, Sinkala M, ChintuC, Kaseba C, Kasolo F, Gitau R, Tomkins A, Murray S, Filteau S.Risk factors for subclinical mastitis among HIV-infected anduninfected women in Lusaka, Zambia. Paediatr Perinat Epidemiol.

  22. 2006 Sep;20(5):379-91. doi: 10.1111/j.1365-3016.2006.00746.x.PMID: 16911016.20. Schaub R, Badiou S, Viljoen J, Dujols P, Bolloré K, Van de Perre P,Newell ML, Bland R, Nagot N, Tuaillon E. Th e immune response tosub-clinical mastitis is impaired in HIV-infected women. J TranslMed. 2018 Oct 25;16(1):296. doi: 10.1186/s12967-018-1667-4.PMID: 30359283; PMCID: PMC6202806.

  23. Dorosko SM, Th ea DM, Saperstein G, Russell RM, Paape MJ,Hinckley LS, Decker WD, Semrau K, Sinkala M, Kasonde P,Kankasa C, Aldrovandi GM, Hamer DH. Veterinary fi eld testas screening tool for mastitis and HIV-1 viral load in breastmilkfrom HIV-infected Zambian women. Breastfeed Med. 2007Sep;2(3):172-5. doi: 10.1089/bfm.2007.0007. PMID: 17903106;PMCID: PMC6701680.

  24. Salado-Rasmussen K, Th eilgaard ZP, Chiduo MG, Bygbjerg IC,Gerstoft J, Lüneborg-Nielsen M, Lemnge M, Katzenstein TL.Nevirapine, sodium concentration and HIV-1 RNA in breast milkand plasma among HIV-infected women receiving short-courseantiretroviral prophylaxis. PLoS One. 2015 Mar 26;10(3):e0121111.doi: 10.1371/journal.pone.0121111. PMID: 25812161; PMCID:PMC4374672.

  25. Sanosyan A, Rutagwera DG, Molès JP, Bollore K, Peries M, KankasaC, Mwiya M, Tylleskär T, Nagot N, Van De Perre P, Tuaillon E; ANRS12174 Trial Group (see composition at the AcknowledgmentsSection). Increased Epstein-Barr virus in breast milk occurs withsubclinical mastitis and HIV shedding. Medicine (Baltimore). 2016Jul;95(27):e4005. doi: 10.1097/MD.0000000000004005. PMID:27399077; PMCID: PMC5058806.

  26. Willumsen JF, Filteau SM, Coutsoudis A, Newell ML, RollinsNC, Coovadia HM, Tomkins AM. Breastmilk RNA viral loadin HIV-infected South African women: eff ects of subclinicalmastitis and infant feeding. AIDS. 2003 Feb 14;17(3):407-14. doi:10.1097/00002030-200302140-00015. PMID: 12556695.

  27. Bosire R, John-Stewart GC, Mabuka JM, Wariua G, Gichuhi C,Wamalwa D, Ruzinski J, Goodman R, Lohman B, Mbori-NgachaDA, Overbaugh J, Farquhar C. Breast milk alpha-defensinsare associated with HIV type 1 RNA and CC chemokines inbreast milk but not vertical HIV type 1 transmission. AIDSRes Hum Retroviruses. 2007 Feb;23(2):198-203. doi: 10.1089/aid.2006.0125. PMID: 17331027; PMCID: PMC3382116.

  28. Gantt S, Carlsson J, Shetty AK, Seidel KD, Qin X, MutsvangwaJ, Musingwini G, Woelk G, Zijenah LS, Katzenstein DA,Frenkel LM. Cytomegalovirus and Epstein-Barr virus inbreast milk are associated with HIV-1 shedding but not withmastitis. AIDS. 2008 Jul 31;22(12):1453-60. doi: 10.1097/QAD.0b013e32830184f2. PMID: 18614868; PMCID:PMC2504751.

  29. Makasa M, Kasonka L, Chisenga M, Sinkala M, Chintu C,Tomkins A, Filteau S. Early growth of infants of HIV-infectedand uninfected Zambian women. Trop Med Int Health. 2007May;12(5):594-602. doi: 10.1111/j.1365-3156.2007.01836.x.PMID: 17445127.

  30. Rossenkhan R, Novitsky V, Sebunya TK, Leidner J, HaganJE, Moyo S, Smeaton L, Lockman S, Musonda R, Ndung’uT, Gaseitsiwe S, Thior I, Mmalane M, Makhema J, Essex M,Shapiro R. Infant feeding practices were not associated withbreast milk HIV-1 RNA levels in a randomized clinical trial inBotswana. AIDS Behav. 2012 Jul;16(5):1260-4. doi: 10.1007/s10461-011-0035-7. PMID: 21901486; PMCID: PMC3523667.

  31. Rutagwera DG, Molès JP, Kankasa C, Mwiya M, Tuaillon E,Peries M, Nagot N, Van de Perre P, Tylleskär T; ANRS12174consortium. Prevalence and determinants of HIV sheddingin breast milk during continued breastfeeding amongZambian mothers not on antiretroviral treatment (ART):A cross-sectional study. Medicine (Baltimore). 2019Nov;98(44):e17383. doi: 10.1097/MD.0000000000017383.PMID: 31689745; PMCID: PMC6946397.

  32. Lohman-Payne B, Slyker JA, Moore S, Maleche-Obimbo E,Wamalwa DC, Richardson BA, Rowland-Jones S, Mbori-Ngacha D, Farquhar C, Overbaugh J, John-Stewart G.Breast milk cellular HIV-specific interferon γ responsesare associated with protection from peripartum HIVtransmission. AIDS. 2012 Oct 23;26(16):2007-16. doi:10.1097/QAD.0b013e328359b7e0. PMID: 22948269; PMCID:PMC3718292.

  33. Tomkins A. Malnutrition, morbidity and mortality in childrenand their mothers. Proc Nutr Soc. 2000 Feb;59(1):135-46. doi:10.1017/s0029665100000161. PMID: 10828183.

  34. Tuaillon E, Viljoen J, Dujols P, Cambonie G, Rubbo PA,Nagot N, Bland RM, Badiou S, Newell ML, Van de Perre P.Subclinical mastitis occurs frequently in association withdramatic changes in inflammatory/anti-inflammatory breastmilk components. Pediatr Res. 2017 Apr;81(4):556-564. doi:10.1038/pr.2016.220. Epub 2016 Nov 4. PMID: 27814344.

  35. Li C, Solomons NW, Scott ME, Koski KG. Subclinical mastitis(SCM) and proinflammatory cytokines are associated withmineral and trace element concentrations in human breastmilk. J Trace Elem Med Biol. 2018 Mar;46:55-61. doi: 10.1016/j.jtemb.2017.11.010. Epub 2017 Nov 16. PMID: 29413111.

  36. Wren-Atilola HM, Solomons NW, Scott ME, Koski KG. Infantgrowth faltering linked to subclinical mastitis, maternalfaecal-oral contamination, and breastfeeding. Matern ChildNutr. 2019 Jul;15(3):e12756. doi: 10.1111/mcn.12756. Epub2019 Jan 13. PMID: 30472802; PMCID: PMC7199076.

  37. Li C, Solomons NW, Scott ME, Koski KG. Anthropometry beforeDay 46 and Growth Velocity before 6 Months of GuatemalanBreastfed Infants Are Associated with Subclinical Mastitis andMilk Cytokines, Minerals, and Trace Elements. J Nutr. 2019 Sep1;149(9):1651-1659. doi: 10.1093/jn/nxz109. PMID: 31187864.

  38. Wren-Atilola HM, Solomons NW, Scott ME, Koski KG. InfantAnthropometry and Growth Velocity Before 6 Months areAssociated with Breastfeeding Practices and the Presenceof Subclinical Mastitis and Maternal Intestinal Protozoa inIndigenous Communities in Guatemala. Curr Dev Nutr. 2021 Sep16;5(9):nzab086. doi: 10.1093/cdn/nzab086. PMID: 34585057;PMCID: PMC8460162.

  39. Lopez Leyva L, Gonzalez E, Li C, Ajeeb T, Solomons NW,Agellon LB, Scott ME, Koski KG. Human Milk Microbiota inan Indigenous Population Is Associated with Maternal Factors,Stage of Lactation, and Breastfeeding Practices. Curr Dev Nutr.2021 Apr 15;5(4):nzab013. doi: 10.1093/cdn/nzab013. PMID:33898919; PMCID: PMC8053399.

  40. Samuel TM, De Castro CA, Dubascoux S, Aff olter M, Giuff ridaF, Billeaud C, Picaud JC, Agosti M, Al-Jashi I, Pereira AB,Costeira MJ, Silva MG, Marchini G, Rakza T, Haaland K, StirisT, Stoicescu SM, Martínez-Costa C, Vanpee M, Domellöf M,Euridice CG, Th akkar SK, Silva-Zolezzi I. Subclinical Mastitis ina European Multicenter Cohort: Prevalence, Impact on HumanMilk (HM) Composition, and Association with Infant HM Intakeand Growth. Nutrients. 2019 Dec 30;12(1):105. doi: 10.3390/nu12010105. PMID: 31905959; PMCID: PMC7019749.

  41. Angelopoulou A, Field D, Pérez-Ibarreche M, Warda AK, Hill C,Ross RP. Vancomycin and nisin A are eff ective against biofi lms ofmulti-drug resistant Staphylococcus aureus isolates from humanmilk. PLoS One. 2020 May 29;15(5):e0233284. doi: 10.1371/journal.pone.0233284. PMID: 32469943; PMCID: PMC7259672.

  42. Aryeetey RN, Marquis GS, Brakohiapa L, Timms L, Lartey A.Subclinical mastitis may not reduce breastmilk intake duringestablished lactation. Breastfeed Med. 2009 Sep;4(3):161-6. doi: 10.1089/bfm.2008.0131. PMID: 19243263; PMCID:PMC2932540.

  43. Kotiw M, Zhang GW, Daggard G, Reiss-Levy E, Tapsall JW, NumaA. Late-onset and recurrent neonatal Group B streptococcaldisease associated with breast-milk transmission. Pediatr DevPathol. 2003 May-Jun;6(3):251-6. doi: 10.1007/s10024-001-0276-y. Epub 2003 Apr 14. PMID: 12687430.

  44. Li X, Sanz J, Argudo N, Vernet-Tomas M, Rodríguez N, TorrentL, Fernández-Velilla E, Pera O, Huang Y, Nicolau P, Jiménez M,Segura M, Algara M. Intraoperative irradiation in breast cancer:preliminary results in 80 patients as partial breast irradiationor anticipated boost prior to hypo-fractionated whole breastirradiation. Clin Transl Oncol. 2021 Nov 18. doi: 10.1007/s12094-021-02728-0. Epub ahead of print. PMID: 34792725.

  45. Yaghan R, Hamouri S, Ayoub NM, Yaghan L, Mazahreh T. AProposal of a Clinically Based Classifi cation for IdiopathicGranulomatous Mastitis. Asian Pac J Cancer Prev. 2019 Mar26;20(3):929-934. doi: 10.31557/APJCP.2019.20.3.929. PMID:30912417; PMCID: PMC6825786.

  46. Li M, Tang S. [Analysis of risk factors related to periprostheticinfection aft er breast augmentation]. Zhongguo Xiu Fu ChongJian Wai Ke Za Zhi. 2019 Jul 15;33(7):889-893. Chinese. doi:10.7507/1002-1892.201901093. PMID: 31298009; PMCID:PMC8337435.

  47. Espínola-Docio B, Costa-Romero M, Díaz-Gómez NM, Paricio-Talayero JM; Comité de Lactancia Materna, Asociación Españolade Pediatría. Mastitis. Puesta al día [Mastitis update.]. ArchArgent Pediatr. 2016 Dec 1;114(6):576-584. Spanish. doi: 10.5546/aap.2016.576. PMID: 27869418.

  48. Angelopoulou A, Field D, Ryan CA, Stanton C, Hill C, RossRP. Th e microbiology and treatment of human mastitis. MedMicrobiol Immunol. 2018 Apr;207(2):83-94. doi: 10.1007/s00430-017-0532-z. Epub 2018 Jan 19. PMID: 29350290.

  49. Fernández L, Arroyo R, Espinosa I, Marín M, Jiménez E,Rodríguez JM. Probiotics for human lactational mastitis. BenefMicrobes. 2014 Jun 1;5(2):169-83. doi: 10.3920/BM2013.0036.PMID: 24463206.

  50. Jiménez E, de Andrés J, Manrique M, Pareja-Tobes P, Tobes R,Martínez-Blanch JF, Codoñer FM, Ramón D, Fernández L,Rodríguez JM. Metagenomic Analysis of Milk of Healthy andMastitis-Suff ering Women. J Hum Lact. 2015 Aug;31(3):406-15. doi: 10.1177/0890334415585078. Epub 2015 May 6. PMID:25948578.

  51. Betts RC, Johnson HM, Eglash A, Mitchell KB. It’s Not Yeast:Retrospective Cohort Study of Lactating Women with PersistentNipple and Breast Pain. Breastfeed Med. 2021 Apr;16(4):318-324. doi: 10.1089/bfm.2020.0160. Epub 2020 Dec 10. PMID:33305975.

  52. Jiménez E, Arroyo R, Cárdenas N, Marín M, Serrano P,Fernández L, Rodríguez JM. Mammary candidiasis: A medicalcondition without scientifi c evidence? PLoS One. 2017 Jul13;12(7):e0181071. doi: 10.1371/journal.pone.0181071. PMID:28704470; PMCID: PMC5509296.

  53. Boix-Amorós A, Hernández-Aguilar MT, Artacho A, ColladoMC, Mira A. Human milk microbiota in sub-acute lactationalmastitis induces infl ammation and undergoes changes incomposition, diversity and load. Sci Rep. 2020 Oct 28;10(1):18521.doi: 10.1038/s41598-020-74719-0. PMID: 33116172; PMCID:PMC7595153.

  54. Mitchell KB, Eglash A, Bamberger ET. Mammary Dysbiosisand Nipple Blebs Treated With Intravenous Daptomycinand Dalbavancin. J Hum Lact. 2020 May;36(2):365-368. doi:10.1177/0890334419862214. Epub 2019 Jul 16. PMID: 31310726.

  55. Organizació n Panamericana de la Salud. Clasifi cació n estadísticainternacional de enfermedades y problemas relacionados conla salud. 10a. revisió n. Washington, D.C. : OPS, © 1995 3 v. —(Publicació n Cientí fi ca ; 554)

  56. Foxman B, D’Arcy H, Gillespie B, Bobo JK, Schwartz K. Lactationmastitis: occurrence and medical management among 946breastfeeding women in the United States. Am J Epidemiol.2002 Jan 15;155(2):103-14. doi: 10.1093/aje/155.2.103. PMID:11790672.

  57. Rodríguez JM, Fernández L, Verhasselt V. Th e Gut‒Breast Axis:Programming Health for Life. Nutrients. 2021 Feb 12;13(2):606.doi: 10.3390/nu13020606. PMID: 33673254; PMCID:PMC7917897.

  58. Demmelmair H, Jiménez E, Collado MC, Salminen S, McGuireMK. Maternal and Perinatal Factors Associated with the HumanMilk Microbiome. Curr Dev Nutr. 2020 Mar 9;4(4):nzaa027. doi:10.1093/cdn/nzaa027. PMID: 32270132; PMCID: PMC7127925.

  59. Arroyo, R., Mediano, P., Martín, V., Jiménez, E., Delgado, S.,Fernández, L.,Rodríguez, J. M. (2011). Diagnóstico etiológico delas mastitis infecciosas: Propuesta de protocolo para el cultivo demuestras de leche humana [Etiological diagnosis of infectiousmastitis: Proposal of a protocol for the culture of human milksamples]. Acta Pediatrica Española, 69(6), 276-281.

  60. Mediano P, Fernández L, Jiménez E, Arroyo R, Espinosa-MartosI, Rodríguez JM, Marín M. Microbial Diversity in Milk of WomenWith Mastitis: Potential Role of Coagulase-Negative Staphylococci,Viridans Group Streptococci, and Corynebacteria. J Hum Lact.2017 May;33(2):309-318. doi: 10.1177/0890334417692968. Epub2017 Mar 10. PMID: 28418794.

  61. Aryeetey RN, Marquis GS, Timms L, Lartey A, Brakohiapa L.Subclinical mastitis is common among Ghanaian women lactating3 to 4 months postpartum. J Hum Lact. 2008 Aug;24(3):263-7.doi: 10.1177/0890334408316077. PMID: 18689713.

  62. Rollins NC, Bhandari N, Hajeebhoy N, Horton S, Lutter ChK,Martines JC, et al. Why invest, and what it will take to improvebreastfeeding practices? Lancet. 2016; 387 (10017), 491-504.




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