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Revista Latinoamericana de Microbiología

2000, Number 3

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Microbiología 2000; 42 (3)

Diagnosis of Chagas' disease

López AFJ, Rangel FH, Ramos C

Language: English
References: 70
Page: 121-129
PDF size: 75.90 Kb.


ABSTRACT

A review is presented on diagnosis of american trypanosomiasis or Chagas' disease, an endemic infectious disease from the American continent. The etiologic agent, Trypanosoma cruzi is transmitted in nature by the reduvidae bugs. In order to select the best diagnostioc procedures, relevant concepts of the immune response and physiopathology of the human host, are summarized. The complexity of Chagas' disease and the difficulties for its diagnosis and treatment evaluation, impose the need to define the best criteria for selecting diagnosis procedures which offer the highest sensitivity and specificity not only to confirm the efficacy of treatment and surveillance for disease transmission, but specially for their utilization at the primary health care level. Timely, sensitive and specific diagnosis of Chagas' disease is linked to the structure and evolution of the parasite populations, the mechanism of pathogenesis and the immune response of human host. Proper diagnosis also depends on the knowledge and evolutionary consequences of medical, entomological and public health interventions. Diagnosis based on parasite characteristics and on human host immune response will contribute to the understanding of Chagas' disease as a collective health problem and for the design and evaluation of interventions for its prevention, integral management and surveillance.


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